{"id":1274,"date":"2026-07-20T16:00:20","date_gmt":"2026-07-20T13:00:20","guid":{"rendered":"https:\/\/life-peptide.com\/?post_type=product&#038;p=1274"},"modified":"2026-07-22T10:52:19","modified_gmt":"2026-07-22T07:52:19","slug":"cjc-1295-with-dac","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/cs\/product\/cjc-1295-with-dac\/","title":{"rendered":"CJC-1295 s DAC \/ 2 mg"},"content":{"rendered":"<p>CJC-1295 with DAC is a modified analogue of <strong>Growth Hormone Releasing Hormone<\/strong> (GHRH) engineered to dramatically extend its duration of action.<\/p>\n<p>Unlike <strong><a href=\"https:\/\/life-peptide.com\/cs\/product\/cjc-1295-no-dac\/\">CJC-1295 no DAC<\/a> (Modified GRF 1-29)<\/strong>, which is cleared relatively quickly, the DAC version contains a Drug Affinity Complex that binds reversibly to circulating albumin. This prolongs circulation from approximately 30 minutes to several days, allowing researchers to investigate <strong>sustained stimulation of the growth hormone axis<\/strong>.<\/p>\n<p>Because of this unique pharmacokinetic profile, CJC-1295 with DAC has become one of the most widely investigated long-acting GHRH analogues in endocrine and metabolism research.<\/p>\n<hr \/>\n<h4><strong>Why CJC-1295 with DAC is widely investigated<\/strong><\/h4>\n<p>Published research has investigated CJC-1295 with DAC in relation to:<\/p>\n<ul>\n<li><strong>sustained growth hormone signalling<\/strong><\/li>\n<li><strong>Regulace IGF-1<\/strong><\/li>\n<li><strong>healthy aging research<\/strong><\/li>\n<li><strong>body composition<\/strong><\/li>\n<li><strong>muscle physiology<\/strong><\/li>\n<li><strong>recovery biology<\/strong><\/li>\n<li><strong>protein metabolism<\/strong><\/li>\n<li><strong>fyziologie endokrinn\u00edho syst\u00e9mu<\/strong><\/li>\n<li><strong>Signalizace receptoru GHRH<\/strong><\/li>\n<\/ul>\n<p>Unlike short-acting GHRH analogues, the DAC version is primarily investigated for maintaining <strong>prolonged GH and IGF-1 elevation<\/strong> rather than generating brief physiological pulses.<\/p>\n<h4><strong>How CJC-1295 with DAC works<\/strong><\/h4>\n<p><strong>Drug Affinity Complex (DAC)<\/strong><\/p>\n<p>The defining feature of this peptide is the Drug Affinity Complex, which enables reversible binding to serum albumin.\u00a0Albumin binding protects the peptide from rapid degradation and renal clearance, extending its biological activity for several days.<\/p>\n<p><strong>Growth hormone release<\/strong><\/p>\n<p>CJC-1295 with DAC activates GHRH receptors in the pituitary gland, stimulating endogenous growth hormone secretion.\u00a0Because the peptide remains in circulation much longer than the No DAC version, published studies have reported sustained increases in circulating GH and IGF-1.<\/p>\n<p><strong>IGF-1 research<\/strong><\/p>\n<p>One of the principal reasons for developing CJC-1295 with DAC was to achieve prolonged elevation of IGF-1, allowing researchers to investigate the effects of sustained GHRH signalling on metabolism and tissue physiology.<\/p>\n<p><strong>Endokrinn\u00ed fyziologie<\/strong><\/p>\n<p>Researchers have also investigated how prolonged GHRH receptor activation differs from physiological pulsatile secretion, making CJC-1295 with DAC an important tool in comparative endocrine research.<\/p>\n<hr \/>\n<h4><strong>Why CJC-1295 with DAC differs from CJC-1295 No DAC<\/strong><\/h4>\n<p>Although they share the same peptide backbone, CJC-1295 with DAC and CJC-1295 No DAC are pharmacologically distinct compounds.<\/p>\n<p><strong>CJC-1295 s DAC<\/strong><\/p>\n<ul>\n<li>Long-acting (approximately 5\u20138-day half-life)<\/li>\n<li>Sustained GH and IGF-1 elevation<\/li>\n<li>Albumin binding through the Drug Affinity Complex<\/li>\n<li>Designed for prolonged endocrine stimulation<\/li>\n<\/ul>\n<p><strong><a href=\"https:\/\/life-peptide.com\/cs\/product\/cjc-1295-no-dac\/\">CJC-1295 no DAC<\/a> (Modified GRF 1-29)<\/strong><\/p>\n<ul>\n<li>Short-acting (approximately 30-minute half-life)<\/li>\n<li>Fyziologick\u00e9 pulzy GH<\/li>\n<li>Rapid clearance<\/li>\n<li>Designed to mimic natural GHRH secretion<\/li>\n<\/ul>\n<p>For this reason, the two peptides are not interchangeable and are often selected for different research objectives.<\/p>\n<h4><strong>Lidsk\u00fd a preklinick\u00fd v\u00fdzkum<\/strong><\/h4>\n<p>CJC-1295 with DAC has progressed into early human clinical investigation.<\/p>\n<p>Published studies demonstrated prolonged increases in circulating growth hormone and IGF-1 following administration, confirming that the Drug Affinity Complex successfully extends biological activity compared with conventional GHRH analogues. Research continues to explore applications in endocrinology, metabolism and healthy aging.<\/p>\n<h4><strong>Publikovan\u00e9 bezpe\u010dnostn\u00ed poznatky<\/strong><\/h4>\n<p>Early clinical studies generally reported <strong>favourable tolerability<\/strong>. The most frequently reported adverse events included mild injection-site reactions and transient flushing. Researchers also noted prolonged elevations of GH and IGF-1 consistent with the peptide&#8217;s extended half-life, which distinguishes it from the shorter-acting No DAC formulation.<\/p>\n<hr \/>\n<h3><strong>Vlastnosti produktu<\/strong><\/h3>\n<p>Aplikace: laboratorn\u00ed a analytick\u00fd v\u00fdzkum<br \/>\nPou\u017eit\u00ed omezen\u00e9: nen\u00ed ur\u010deno k lidsk\u00e9 spot\u0159eb\u011b; pro l\u00e9ka\u0159sk\u00e9, veterin\u00e1rn\u00ed ani kosmetick\u00e9 pou\u017eit\u00ed<br \/>\nVyrobeno v za\u0159\u00edzen\u00edch spl\u0148uj\u00edc\u00edch spr\u00e1vnou v\u00fdrobn\u00ed praxi (GMP) za p\u0159\u00edsn\u00fdch protokol\u016f kontroly kvality.<br \/>\nKa\u017ed\u00e1 \u0161ar\u017ee je po v\u00fdrob\u011b pe\u010dliv\u011b laboratorn\u011b testov\u00e1na (Certifik\u00e1t o anal\u00fdze najdete pod obr\u00e1zky produkt\u016f).<br \/>\nLyofilizov\u00e1no (su\u0161eno mrazem) pro maxim\u00e1ln\u00ed stabilitu a prodlou\u017eenou trvanlivost.<br \/>\nUzav\u0159eno ve steriln\u00edch lahvi\u010dk\u00e1ch, p\u0159ipraveno k rekonstituci.<br \/>\nPurity: \u2265 99.64% , HPLC tested<br \/>\nVzhled: b\u00edl\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek<br \/>\nMolekul\u00e1rn\u00ed vzorec: C<sub>165<\/sub>H<sub>269<\/sub>N<sub>47<\/sub>O<sub>46<\/sub><br \/>\nMolecular weight: 3647.65<\/p>\n<p><strong>\u00dalo\u017ei\u0161t\u011b<\/strong>Neotev\u0159en\u00e9 lyofilizovan\u00e9 lahvi\u010dky jsou nejl\u00e9pe skladov\u00e1ny <strong>chlazen\u00e9 p\u0159i 2\u20138 \u00b0C<\/strong>, co\u017e je metoda skladov\u00e1n\u00ed potvrzen\u00e1 na\u0161\u00edm v\u00fdrobn\u00edm partnerem a vhodn\u00e1 a\u017e po dobu 24 m\u011bs\u00edc\u016f. Preferuje se chlazen\u00ed, proto\u017ee minimalizuje zbyte\u010dn\u00e9 cykly zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed b\u011bhem b\u011b\u017en\u00e9 manipulace. Pokud je vy\u017eadov\u00e1no podstatn\u011b del\u0161\u00ed skladov\u00e1n\u00ed, lze zmrazen\u00e9 uchov\u00e1vat i neotev\u0159en\u00e9 lyofilizovan\u00e9 lahvi\u010dky. Po rekonstituci v\u017edy skladujte p\u0159i 2\u20138 \u00b0C a nezmrazujte.<\/p>\n<h4><strong>Rekonstituce a manipulace<\/strong><\/h4>\n<p>CJC-1295 je dod\u00e1v\u00e1n v lyofilizovan\u00e9 lahvi\u010dce a m\u011bl by b\u00fdt zpracov\u00e1v\u00e1n pomoc\u00ed standardn\u00edch postup\u016f pro rekonstituci peptid\u016f vhodn\u00fdch pro v\u00fdzkumn\u00e9 prost\u0159ed\u00ed. Mus\u00ed b\u00fdt rekonstituov\u00e1n s <a href=\"https:\/\/life-peptide.com\/cs\/product\/bac-10-ml\/\">bakteriostatick\u00e1 voda<\/a> p\u0159ed pou\u017eit\u00edm. Pro zachov\u00e1n\u00ed struktur\u00e1ln\u00ed integrity p\u0159idejte zvolen\u00e9 rozpou\u0161t\u011bdlo pomalu po vnit\u0159n\u00ed st\u011bn\u011b lahvi\u010dky nam\u00edsto p\u0159\u00edmo na peptidov\u00fd pr\u00e1\u0161ek a vyhn\u011bte se prudk\u00e9mu prot\u0159ep\u00e1v\u00e1n\u00ed. Jemn\u00e9 krou\u017een\u00ed je obecn\u011b dosta\u010duj\u00edc\u00ed, jakmile se peptid zcela rozpust\u00ed. Standardn\u00ed laboratorn\u00ed postupy zahrnuj\u00ed tak\u00e9 ponech\u00e1n\u00ed chlazen\u00fdch lahvi\u010dek dos\u00e1hnout pokojov\u00e9 teploty p\u0159ed rekonstituc\u00ed, aby se minimalizovala kondenzace uvnit\u0159 lahvi\u010dky.<\/p>\n<p>Pro dal\u0161\u00ed pokyny k v\u00fdb\u011bru rozpou\u0161t\u011bdla, pl\u00e1nov\u00e1n\u00ed koncentrac\u00ed a skladov\u00e1n\u00ed viz \u00fapln\u00e9 <a href=\"https:\/\/life-peptide.com\/cs\/reconstitution-of-peptides\/\">Pr\u016fvodce rekonstituc\u00ed peptid\u016f<\/a> a <a href=\"https:\/\/life-peptide.com\/cs\/calculator\/\">Kalkula\u010dka rekonstituce<\/a>.<\/p>\n<hr \/>\n<h4><strong>Vybran\u00e9 v\u00fdzkumn\u00e9 reference<\/strong><\/h4>\n<ul>\n<li>Teichman SL, et al. <em>Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, Journal of Clinical Endocrinology &amp; Metabolism<\/em>, 2006<\/li>\n<\/ul>\n<p>The landmark first-in-human study demonstrating prolonged increases in GH and IGF-1 following administration of CJC-1295 with DAC.<\/p>\n<ul>\n<li>Drug Affinity Complex pharmacology<\/li>\n<\/ul>\n<p>Research describing albumin binding, extended half-life and pharmacokinetics of CJC-1295 with DAC compared with short-acting Modified GRF (1-29).<\/p>\n<ul>\n<li>Modern comparative reviews<\/li>\n<\/ul>\n<p>Recent reviews summarising the pharmacological differences between CJC-1295 with DAC and CJC-1295 No DAC, with emphasis on sustained versus pulsatile GH signalling.<\/p>\n<hr \/>\n<h4><strong>\u010casto kladen\u00e9 ot\u00e1zky<\/strong><\/h4>\n<p><strong>What is CJC-1295 with DAC?<\/strong><\/p>\n<p>CJC-1295 with DAC is a long-acting analogue of growth hormone-releasing hormone (GHRH). The attached Drug Affinity Complex extends its circulation time, making it widely investigated for sustained GH and IGF-1 signalling.<\/p>\n<p><strong>What does DAC mean?<\/strong><\/p>\n<p>DAC stands for Drug Affinity Complex, a chemical modification that enables reversible albumin binding and dramatically prolongs the peptide&#8217;s half-life.<\/p>\n<p><strong>How is CJC-1295 with DAC different from No DAC?<\/strong><\/p>\n<p>The DAC version provides prolonged GH and IGF-1 elevation, whereas CJC-1295 No DAC (Modified GRF 1-29) produces short-lived, physiological GH pulses. They are different research tools rather than different strengths of the same peptide.<\/p>\n<p><strong>Why is CJC-1295 with DAC investigated for IGF-1?<\/strong><\/p>\n<p>Its extended duration of action allows researchers to study sustained stimulation of the GH\/IGF-1 axis over several days rather than transient hormone pulses.<\/p>\n<p><strong>Can CJC-1295 with DAC be combined with other GH peptides?<\/strong><\/p>\n<p>In published research, CJC-1295 with DAC has often been discussed alongside peptides that stimulate growth hormone through complementary mechanisms, including Ipamorelin. The combination is investigated because the peptides act through different receptor systems, although each retains a distinct pharmacological profile.<\/p>\n<p><strong>Je tento produkt ur\u010den k lidsk\u00e9mu pou\u017eit\u00ed?<\/strong><\/p>\n<p>No. CJC-1295 with DAC supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.<\/p>\n<hr \/>\n<h4><strong>Souvisej\u00edc\u00ed v\u00fdzkumn\u00fd kontext<\/strong><\/h4>\n<p>CJC-1295 with DAC is frequently discussed alongside other research peptides investigating growth hormone signalling, recovery and healthy aging.<\/p>\n<p><a href=\"https:\/\/life-peptide.com\/cs\/product\/cjc-1295-no-dac\/\"><strong>CJC-1295 no DAC<\/strong><\/a> (Modified GRF 1-29) \u2013 investigated for physiological pulsatile growth hormone release and short-duration GHRH signalling.<br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/ipamorelin-5-mg\/\"><strong>Ipamorelin<\/strong> <\/a>\u2013 studied as a selective ghrelin receptor agonist that stimulates endogenous growth hormone release through a complementary pathway.<br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/tesamorelin-10-mg\/\"><strong>Tesamorelin<\/strong> <\/a>\u2013 investigated as a clinically validated GHRH analogue with established endocrine research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/mots-c-10-mg\/\"><strong>MOTS-c<\/strong> <\/a>\u2013 focuses on mitochondrial metabolism, exercise adaptation and healthy aging rather than direct GH signalling.<br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/epitalon-10-mg\/\"><strong>Epitalon<\/strong> <\/a>\u2013 investigated for telomere biology, circadian regulation and longevity research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/ss-31\/\"><strong>SS-31<\/strong><\/a> \u2013 investigated for mitochondrial function and cellular bioenergetics.<\/p>\n<p>Although these peptides are often grouped within performance and healthy aging research, CJC-1295 with DAC is distinguished by its sustained activation of the growth hormone axis, whereas the others target different biological pathways.<\/p>\n<p><strong>POZN\u00c1MKA<\/strong>Toto je pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nep\u0159edstavuje l\u00e9ka\u0159skou radu.<\/p>\n<p><strong>Z\u0159eknut\u00ed se odpov\u011bdnosti<\/strong><br \/>\nTento produkt je prod\u00e1v\u00e1n pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely. Nen\u00ed ur\u010den k diagnostice, l\u00e9\u010db\u011b, vyl\u00e9\u010den\u00ed nebo prevenci jak\u00fdchkoli onemocn\u011bn\u00ed. Kupuj\u00edc\u00ed p\u0159eb\u00edr\u00e1 plnou odpov\u011bdnost za \u0159\u00e1dnou manipulaci a pou\u017eit\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>CJC-1295 with DAC \/ 2 mg is a research-grade long-acting GHRH analogue supplied in lyophilised form for laboratory use. By incorporating a Drug Affinity Complex (DAC), it remains active for several days, making it one of the best-known peptides for sustained growth hormone and IGF-1 research.<\/p>\n<p>||<\/p>\n<p>Purity \u226599% | EU Shipping from \u20ac5 | Free shipping upgrades available | Card payments accepted<\/p>","protected":false},"featured_media":1273,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[21],"product_tag":[354,358,356,290,357,320,355,282],"class_list":["post-1274","product","type-product","status-publish","has-post-thumbnail","product_cat-growth-hormone-secretagogues","product_tag-cjc-1295-with-dac","product_tag-endocrine-research","product_tag-ghrh-analogue","product_tag-growth-hormone-peptide","product_tag-healthy-aging-peptide","product_tag-igf-1-research","product_tag-long-acting-ghrh","product_tag-recovery-peptide","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product\/1274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/comments?post=1274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/media\/1273"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/media?parent=1274"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product_brand?post=1274"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product_cat?post=1274"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product_tag?post=1274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}