{"id":879,"date":"2026-04-23T15:45:49","date_gmt":"2026-04-23T12:45:49","guid":{"rendered":"https:\/\/life-peptide.com\/?post_type=product&#038;p=879"},"modified":"2026-07-22T11:03:05","modified_gmt":"2026-07-22T08:03:05","slug":"tesamorelin-10-mg","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/cs\/product\/tesamorelin-10-mg\/","title":{"rendered":"Tesamorelin 10 mg"},"content":{"rendered":"<p>Tesamorelin is a synthetic analogue of <strong>human growth hormone-releasing hormone<\/strong> (GHRH) consisting of the full 44-amino-acid GHRH sequence with structural modifications that improve stability and resistance to enzymatic degradation.<\/p>\n<p>Unlike GHRP peptides, which stimulate the ghrelin receptor (GHSR-1a), Tesamorelin acts <strong>directly on the GHRH receptor in the anterior pituitary<\/strong>, promoting physiological pulsatile secretion of endogenous growth hormone. This receptor selectivity has made Tesamorelin one of the <strong>most thoroughly investigated peptides<\/strong> in growth hormone physiology and metabolic research.<\/p>\n<hr \/>\n<h4><strong>Why Tesamorelin matters in endocrine research<\/strong><\/h4>\n<p>Tesamorelin differs from many secretagogues because it <strong>closely mimics the body&#8217;s natural GHRH signalling<\/strong> rather than activating ghrelin pathways.<\/p>\n<p>Published research has investigated Tesamorelin in relation to:<\/p>\n<ul>\n<li><strong>pulsatile growth hormone secretion<\/strong><\/li>\n<li><strong>Regulace IGF-1<\/strong><\/li>\n<li><strong>body composition<\/strong><\/li>\n<li><strong>visceral adipose tissue<\/strong><\/li>\n<li><strong>hepatic fat<\/strong><\/li>\n<li><strong>fyziologie endokrinn\u00edho syst\u00e9mu<\/strong><\/li>\n<li><strong>metabolic regulation<\/strong><\/li>\n<li><strong>funkce hypof\u00fdzy<\/strong><\/li>\n<\/ul>\n<p>Its extensive human evidence base has established Tesamorelin as one of the best-characterised GHRH analogues available for metabolic and endocrine research.<\/p>\n<h4><strong>How Tesamorelin works<\/strong><\/h4>\n<p>Unlike GHRP peptides, Tesamorelin activates the growth hormone-releasing hormone receptor (GHRHR).<\/p>\n<p>Publikovan\u00fd v\u00fdzkum zkoumal jeho vztah s:<\/p>\n<p><strong>Growth hormone secretion<\/strong><\/p>\n<p>Tesamorelin stimulates physiological pulsatile release of endogenous growth hormone through direct activation of pituitary GHRH receptors.<\/p>\n<p><strong>Regulace IGF-1<\/strong><\/p>\n<p>Clinical studies consistently demonstrate increased circulating IGF-1 following Tesamorelin administration, making it an important research tool for GH-axis physiology.<\/p>\n<p><strong>Body composition<\/strong><\/p>\n<p>A major area of investigation has been the relationship between endogenous GH stimulation and changes in visceral adipose tissue and lean body mass.<\/p>\n<p><strong>Metabolic physiology<\/strong><\/p>\n<p>Researchers have also investigated hepatic fat metabolism, lipid regulation and broader metabolic adaptations associated with physiological GH release.<\/p>\n<h4><strong>Why Tesamorelin is widely investigated in metabolic research<\/strong><\/h4>\n<p>Among growth hormone secretagogues, Tesamorelin occupies a unique position because much of its research has focused on <strong>metabolic health rather than growth hormone deficiency alone<\/strong>.<\/p>\n<p>Published studies have explored:<\/p>\n<ul>\n<li><strong>visceral adipose tissue<\/strong><\/li>\n<li><strong>hepatic fat<\/strong><\/li>\n<li><strong>body composition<\/strong><\/li>\n<li><strong>metabolic syndrome<\/strong><\/li>\n<li><strong>IGF-1 physiology<\/strong><\/li>\n<li><strong>endocrine regulation<\/strong><\/li>\n<li><strong>HIV-associated lipodystrophy<\/strong><\/li>\n<\/ul>\n<p>This broad clinical evidence has made Tesamorelin one of the most important peptides for studying the interaction between the growth hormone axis and metabolic physiology.<\/p>\n<h4><strong>Lidsk\u00fd a preklinick\u00fd v\u00fdzkum<\/strong><\/h4>\n<p>Tesamorelin has one of the <strong>strongest clinical evidence<\/strong> bases among all growth hormone secretagogues.<\/p>\n<p>Multiple Phase III studies have investigated its effects on growth hormone secretion, visceral adipose tissue, lipid metabolism and hepatic fat. Unlike many research peptides, Tesamorelin has also received regulatory approval for one specific clinical indication, resulting in extensive long-term human safety and efficacy data.<\/p>\n<h4><strong>How Tesamorelin differs from other GH secretagogues<\/strong><\/h4>\n<p><strong>Tesamorelin<\/strong><\/p>\n<ul>\n<li>Analogon GHRH<\/li>\n<li>Direct GHRH receptor activation<\/li>\n<li>Strong clinical evidence<\/li>\n<li>Extensive metabolic research<\/li>\n<\/ul>\n<p><a href=\"https:\/\/life-peptide.com\/cs\/product\/cjc-1295-no-dac\/\"><strong>CJC-1295 (No DAC)<\/strong><\/a><\/p>\n<ul>\n<li>Analogon GHRH<\/li>\n<li>Longer research half-life<\/li>\n<li>Primarily experimental<\/li>\n<\/ul>\n<p><a href=\"https:\/\/life-peptide.com\/cs\/product\/ipamorelin-5-mg\/\"><strong>Ipamorelin<\/strong><\/a><\/p>\n<ul>\n<li>Agonista ghrelinov\u00e9ho receptoru<\/li>\n<li>Selektivn\u00ed sekretagog GH<\/li>\n<li>Minimal appetite effects<\/li>\n<\/ul>\n<p><a href=\"https:\/\/life-peptide.com\/cs\/product\/ghrp-2-5-mg\/\"><strong>GHRP-2<\/strong><\/a><\/p>\n<ul>\n<li>Potentn\u00ed agonista ghrelinov\u00fdch receptor\u016f<\/li>\n<li>Robust GH pulses<\/li>\n<li>Endokrinn\u00ed fyziologie<\/li>\n<\/ul>\n<p><a href=\"https:\/\/life-peptide.com\/cs\/product\/ghrp-6-5-mg\/\"><strong>GHRP-6<\/strong><\/a><\/p>\n<ul>\n<li>Agonista ghrelinov\u00e9ho receptoru<\/li>\n<li>Chu\u0165 k j\u00eddlu a v\u00fdzkum GH<\/li>\n<li>Gastrointestin\u00e1ln\u00ed fyziologie<\/li>\n<li>Publikovan\u00e9 bezpe\u010dnostn\u00ed poznatky<\/li>\n<\/ul>\n<p>Published clinical studies have generally reported Tesamorelin to be <strong>well tolerated<\/strong>. The most commonly reported adverse events included injection-site <strong>reactions, arthralgia, peripheral oedema<\/strong> and transient increases in IGF-1, with gastrointestinal effects occurring less frequently than with many modern metabolic peptides. Safety findings are derived from controlled clinical trials conducted primarily in patients with HIV-associated lipodystrophy.<\/p>\n<hr \/>\n<h3><strong>Vlastnosti produktu<\/strong><\/h3>\n<p>Aplikace: laboratorn\u00ed a analytick\u00fd v\u00fdzkum<br \/>\nPou\u017eit\u00ed omezen\u00e9: nen\u00ed ur\u010deno k lidsk\u00e9 spot\u0159eb\u011b; pro l\u00e9ka\u0159sk\u00e9, veterin\u00e1rn\u00ed ani kosmetick\u00e9 pou\u017eit\u00ed<br \/>\nVyrobeno v za\u0159\u00edzen\u00edch spl\u0148uj\u00edc\u00edch spr\u00e1vnou v\u00fdrobn\u00ed praxi (GMP) za p\u0159\u00edsn\u00fdch protokol\u016f kontroly kvality.<br \/>\nKa\u017ed\u00e1 \u0161ar\u017ee je po v\u00fdrob\u011b pe\u010dliv\u011b laboratorn\u011b testov\u00e1na (Certifik\u00e1t o anal\u00fdze najdete pod obr\u00e1zky produkt\u016f).<br \/>\nLyofilizov\u00e1no (su\u0161eno mrazem) pro maxim\u00e1ln\u00ed stabilitu a prodlou\u017eenou trvanlivost.<br \/>\nUzav\u0159eno ve steriln\u00edch lahvi\u010dk\u00e1ch, p\u0159ipraveno k rekonstituci.<br \/>\nPurity: \u2265 99% (HPLC)<br \/>\nVzhled: b\u00edl\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek<br \/>\nMolekul\u00e1rn\u00ed vzorec: C<sub>221<\/sub>H<sub>366<\/sub>N<sub>72<\/sub>O<sub>67<\/sub>S<br \/>\nMolecular weight: 5135.78<br \/>\nCAS No: 218949-48-5<\/p>\n<p><strong>\u00dalo\u017ei\u0161t\u011b<\/strong>Neotev\u0159en\u00e9 lyofilizovan\u00e9 lahvi\u010dky jsou nejl\u00e9pe skladov\u00e1ny<strong> chlazen\u00e9 p\u0159i 2\u20138 \u00b0C<\/strong>, co\u017e je metoda skladov\u00e1n\u00ed potvrzen\u00e1 na\u0161\u00edm v\u00fdrobn\u00edm partnerem a vhodn\u00e1 a\u017e po dobu 24 m\u011bs\u00edc\u016f. Preferuje se chlazen\u00ed, proto\u017ee minimalizuje zbyte\u010dn\u00e9 cykly zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed b\u011bhem b\u011b\u017en\u00e9 manipulace. Pokud je vy\u017eadov\u00e1no podstatn\u011b del\u0161\u00ed skladov\u00e1n\u00ed, lze zmrazen\u00e9 uchov\u00e1vat i neotev\u0159en\u00e9 lyofilizovan\u00e9 lahvi\u010dky. Po rekonstituci v\u017edy skladujte p\u0159i 2\u20138 \u00b0C a nezmrazujte.<\/p>\n<h4><strong>Rekonstituce a manipulace<\/strong><\/h4>\n<p>Tesamorelin is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with <a href=\"https:\/\/life-peptide.com\/cs\/product\/bac-10-ml\/\">bakteriostatick\u00e1 voda<\/a> p\u0159ed pou\u017eit\u00edm. Pro zachov\u00e1n\u00ed struktur\u00e1ln\u00ed integrity p\u0159idejte zvolen\u00e9 rozpou\u0161t\u011bdlo pomalu po vnit\u0159n\u00ed st\u011bn\u011b lahvi\u010dky nam\u00edsto p\u0159\u00edmo na peptidov\u00fd pr\u00e1\u0161ek a vyhn\u011bte se prudk\u00e9mu prot\u0159ep\u00e1v\u00e1n\u00ed. Jemn\u00e9 krou\u017een\u00ed je obecn\u011b dosta\u010duj\u00edc\u00ed, jakmile se peptid zcela rozpust\u00ed. Standardn\u00ed laboratorn\u00ed postupy zahrnuj\u00ed tak\u00e9 ponech\u00e1n\u00ed chlazen\u00fdch lahvi\u010dek dos\u00e1hnout pokojov\u00e9 teploty p\u0159ed rekonstituc\u00ed, aby se minimalizovala kondenzace uvnit\u0159 lahvi\u010dky.<\/p>\n<p>Pro dal\u0161\u00ed pokyny k v\u00fdb\u011bru rozpou\u0161t\u011bdla, pl\u00e1nov\u00e1n\u00ed koncentrac\u00ed a skladov\u00e1n\u00ed viz \u00fapln\u00e9 <a href=\"https:\/\/life-peptide.com\/cs\/reconstitution-of-peptides\/\">Pr\u016fvodce rekonstituc\u00ed peptid\u016f<\/a> a <a href=\"https:\/\/life-peptide.com\/cs\/calculator\/\">Kalkula\u010dka rekonstituce<\/a>.<\/p>\n<hr \/>\n<h4><strong>Kl\u00ed\u010dov\u00e9 publikovan\u00e9 studie<\/strong><\/h4>\n<ul>\n<li>Falutz J, Allas S, Blot K, et al. <em>Metabolic Effects of a Growth Hormone-Releasing Factor in Patients with HIV. New England Journal of Medicine<\/em>, 2007.<\/li>\n<\/ul>\n<p>The pivotal Phase III study demonstrating reductions in visceral adipose tissue following Tesamorelin treatment while preserving lean body mass.<\/p>\n<ul>\n<li>Stanley TL, Feldpausch MN, Oh J, et al. <em>Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation. JAMA,<\/em> 2014.<\/li>\n<\/ul>\n<p>A landmark study showing reductions in visceral and hepatic fat, expanding Tesamorelin research into metabolic liver physiology.<\/p>\n<ul>\n<li>Spooner LM, et al. <em>Tesamorelin: A Growth Hormone-Releasing Factor Analogue for HIV-Associated Lipodystrophy. Drugs,<\/em> 2012.<\/li>\n<\/ul>\n<p>A comprehensive review covering pharmacology, mechanism of action and clinical development of Tesamorelin.<\/p>\n<ul>\n<li>Badran AS, et al. <em>Body Composition, Hepatic Fat, Metabolic and Safety Outcomes of Tesamorelin: A Meta-analysis of Randomized Controlled Trials. Obesity Research &amp; Clinical Practice<\/em>, 2026.<\/li>\n<\/ul>\n<p>A recent meta-analysis summarising clinical evidence for body composition, liver fat and metabolic outcomes across Tesamorelin trials.<\/p>\n<hr \/>\n<h4><strong>\u010casto kladen\u00e9 ot\u00e1zky<\/strong><\/h4>\n<p><strong>What is Tesamorelin?<\/strong><\/p>\n<p>Tesamorelin is a synthetic analogue of human growth hormone-releasing hormone (GHRH). It stimulates the pituitary gland through the GHRH receptor, promoting physiological pulsatile release of endogenous growth hormone. It is widely investigated in endocrine and metabolic research involving the GH\/IGF-1 axis, body composition and visceral adipose tissue.<\/p>\n<p><strong>How does Tesamorelin differ from CJC-1295?<\/strong><\/p>\n<p>Both Tesamorelin and CJC-1295 are GHRH analogues that activate the same receptor pathway. Tesamorelin has an extensive clinical evidence base, including regulatory approval for HIV-associated lipodystrophy, whereas CJC-1295 remains primarily an experimental research peptide. Their receptor mechanism is similar, but their clinical development differs substantially.<\/p>\n<p><strong>How does Tesamorelin differ from Ipamorelin or GHRP peptides?<\/strong><\/p>\n<p>Tesamorelin stimulates growth hormone release through the GHRH receptor, while Ipamorelin, GHRP-2 and GHRP-6 activate the ghrelin receptor (GHSR-1a). These are complementary physiological pathways, which is why GHRH analogues and GHRP peptides are frequently investigated together in endocrine research.<\/p>\n<p><strong>Why is Tesamorelin widely investigated in metabolic research?<\/strong><\/p>\n<p>Beyond growth hormone physiology, Tesamorelin has been extensively studied for its effects on body composition, visceral adipose tissue, hepatic fat, lipid metabolism and IGF-1 regulation. This broad clinical evidence distinguishes it from many other growth hormone secretagogues.<\/p>\n<p><strong>What research areas commonly investigate Tesamorelin?<\/strong><\/p>\n<p>Published studies have investigated Tesamorelin in growth hormone secretion, IGF-1 regulation, pituitary physiology, body composition, visceral adipose tissue, hepatic fat, metabolic regulation and endocrine signalling.<\/p>\n<p><strong>Can Tesamorelin be combined with GHRP peptides in research?<\/strong><\/p>\n<p>Yes. Because Tesamorelin activates the GHRH receptor while GHRP peptides activate the ghrelin receptor, researchers frequently investigate these pathways together to study complementary mechanisms regulating pulsatile growth hormone secretion. Individual study designs vary, and findings should be interpreted within the context of the published research.<\/p>\n<p><strong>Je tento produkt ur\u010den k lidsk\u00e9mu pou\u017eit\u00ed?<\/strong><\/p>\n<p>No. Tesamorelin supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the scientific literature relating to the Tesamorelin molecule rather than the intended use of this product.<\/p>\n<hr \/>\n<h3><strong>Souvisej\u00edc\u00ed v\u00fdzkumn\u00fd kontext<\/strong><\/h3>\n<p>Tesamorelin belongs to the GHRH analogue and growth hormone signaling research class, which includes peptides investigated for endocrine regulation, GH-axis modulation, and pulsatile hormone release mechanisms.<br \/>\nPro \u0161ir\u0161\u00ed p\u0159ehled sign\u00e1ln\u00edch drah GH a srovn\u00e1vac\u00edch mechanism\u016f peptid\u016f viz na\u0161e <a href=\"\/cs\/growth-hormone-peptides-guide\/\">Pr\u016fvodce v\u00fdzkumem r\u016fstov\u00fdch hormonov\u00fdch peptid\u016f<\/a>.<br \/>\nV\u00fdzkumn\u00edci studuj\u00edc\u00ed interakce osy GH se mohou tak\u00e9 zab\u00fdvat:<\/p>\n<p><a href=\"https:\/\/life-peptide.com\/cs\/product\/cjc-1295-no-dac\/\">CJC-1295 (bez DAC)<\/a><br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/ipamorelin-5-mg\/\">Ipamorelin<\/a><br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/ghrp-2-5-mg\/\">GHRP-2<\/a><br \/>\n<a href=\"https:\/\/life-peptide.com\/cs\/product\/ghrp-6-5-mg\/\">GHRP-6<\/a><\/p>\n<p>Proch\u00e1zet v\u0161echny slou\u010deniny v <a href=\"\/cs\/category\/growth-hormone-secretagogues\/\">Sekre pagy r\u016fstov\u00e9ho hormonu<\/a>.<br \/>\nV\u00fdzkumn\u00edci zkoumaj\u00edc\u00ed endokrinn\u00ed regulaci mohou tak\u00e9 zkoumat slou\u010deniny v <a href=\"\/cs\/category\/metabolic-research-peptides\/\">Metabolick\u00fd v\u00fdzkum<\/a>, v\u010detn\u011b GLP-1 a agonist\u016f inkretin\u016f s v\u00edce dr\u00e1hami.<\/p>\n<p><strong>POZN\u00c1MKA<\/strong>Toto je pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nep\u0159edstavuje l\u00e9ka\u0159skou radu.<\/p>\n<p><strong>Z\u0159eknut\u00ed se odpov\u011bdnosti<\/strong><br \/>\nTento produkt je prod\u00e1v\u00e1n pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely. Nen\u00ed ur\u010den k diagnostice, l\u00e9\u010db\u011b, vyl\u00e9\u010den\u00ed nebo prevenci jak\u00fdchkoli onemocn\u011bn\u00ed. Kupuj\u00edc\u00ed p\u0159eb\u00edr\u00e1 plnou odpov\u011bdnost za \u0159\u00e1dnou manipulaci a pou\u017eit\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>Tesamorelin 10 mg is a research-grade growth hormone-releasing hormone (GHRH) analogue supplied in lyophilised form for laboratory use. It is one of the most extensively studied GHRH peptides, investigated in research on pulsatile growth hormone secretion, IGF-1 regulation, body composition and metabolic physiology.<\/p>\n<p>||<\/p>\n<p>\u010cistota \u226599% | Doprava v r\u00e1mci EU od 5 \u20ac | Mo\u017enost volby dopravy zdarma | P\u0159ij\u00edm\u00e1me platby kartou<\/p>","protected":false},"featured_media":875,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[21],"product_tag":[150,148,147,319,146,320,321],"class_list":["post-879","product","type-product","status-publish","has-post-thumbnail","product_cat-growth-hormone-secretagogues","product_tag-endocrine-research-peptides","product_tag-gh-signaling-research","product_tag-ghrelin-receptor-agonists","product_tag-growth-hormone-research","product_tag-growth-hormone-secretagogues","product_tag-igf-1-research","product_tag-recovery-research","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product\/879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/comments?post=879"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/media\/875"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/media?parent=879"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product_brand?post=879"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product_cat?post=879"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/cs\/wp-json\/wp\/v2\/product_tag?post=879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}