{"id":1274,"date":"2026-07-20T16:00:20","date_gmt":"2026-07-20T13:00:20","guid":{"rendered":"https:\/\/life-peptide.com\/?post_type=product&#038;p=1274"},"modified":"2026-07-21T15:59:06","modified_gmt":"2026-07-21T12:59:06","slug":"cjc-1295-with-dac","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/de\/product\/cjc-1295-with-dac\/","title":{"rendered":"CJC-1295 mit DAC \/ 2 mg"},"content":{"rendered":"<p>CJC-1295 with DAC is a modified analogue of <strong>Growth Hormone Releasing Hormone<\/strong> (GHRH) engineered to dramatically extend its duration of action.<\/p>\n<p>Im Gegensatz zu <strong><a href=\"https:\/\/life-peptide.com\/de\/product\/cjc-1295-ohne-dac\/\">CJC-1295 ohne DAC<\/a> (Modified GRF 1-29)<\/strong>, which is cleared relatively quickly, the DAC version contains a Drug Affinity Complex that binds reversibly to circulating albumin. This prolongs circulation from approximately 30 minutes to several days, allowing researchers to investigate <strong>sustained stimulation of the growth hormone axis<\/strong>.<\/p>\n<p>Because of this unique pharmacokinetic profile, CJC-1295 with DAC has become one of the most widely investigated long-acting GHRH analogues in endocrine and metabolism research.<\/p>\n<hr \/>\n<h4><strong>Why CJC-1295 with DAC is widely investigated<\/strong><\/h4>\n<p>Published research has investigated CJC-1295 with DAC in relation to:<\/p>\n<ul>\n<li><strong>sustained growth hormone signalling<\/strong><\/li>\n<li><strong>IGF-1-Regulierung<\/strong><\/li>\n<li><strong>healthy aging research<\/strong><\/li>\n<li><strong>K\u00f6rperzusammensetzung<\/strong><\/li>\n<li><strong>muscle physiology<\/strong><\/li>\n<li><strong>recovery biology<\/strong><\/li>\n<li><strong>protein metabolism<\/strong><\/li>\n<li><strong>endokrine Physiologie<\/strong><\/li>\n<li><strong>GHRH-Rezeptor-Signal\u00fcbertragung<\/strong><\/li>\n<\/ul>\n<p>Unlike short-acting GHRH analogues, the DAC version is primarily investigated for maintaining <strong>prolonged GH and IGF-1 elevation<\/strong> rather than generating brief physiological pulses.<\/p>\n<h4><strong>How CJC-1295 with DAC works<\/strong><\/h4>\n<p><strong>Drug Affinity Complex (DAC)<\/strong><\/p>\n<p>The defining feature of this peptide is the Drug Affinity Complex, which enables reversible binding to serum albumin.\u00a0Albumin binding protects the peptide from rapid degradation and renal clearance, extending its biological activity for several days.<\/p>\n<p><strong>Growth hormone release<\/strong><\/p>\n<p>CJC-1295 with DAC activates GHRH receptors in the pituitary gland, stimulating endogenous growth hormone secretion.\u00a0Because the peptide remains in circulation much longer than the No DAC version, published studies have reported sustained increases in circulating GH and IGF-1.<\/p>\n<p><strong>IGF-1 research<\/strong><\/p>\n<p>One of the principal reasons for developing CJC-1295 with DAC was to achieve prolonged elevation of IGF-1, allowing researchers to investigate the effects of sustained GHRH signalling on metabolism and tissue physiology.<\/p>\n<p><strong>Endokrine Physiologie<\/strong><\/p>\n<p>Researchers have also investigated how prolonged GHRH receptor activation differs from physiological pulsatile secretion, making CJC-1295 with DAC an important tool in comparative endocrine research.<\/p>\n<hr \/>\n<h4><strong>Why CJC-1295 with DAC differs from CJC-1295 No DAC<\/strong><\/h4>\n<p>Although they share the same peptide backbone, CJC-1295 with DAC and CJC-1295 No DAC are pharmacologically distinct compounds.<\/p>\n<p><strong>CJC-1295 mit DAC<\/strong><\/p>\n<ul>\n<li>Long-acting (approximately 5\u20138-day half-life)<\/li>\n<li>Sustained GH and IGF-1 elevation<\/li>\n<li>Albumin binding through the Drug Affinity Complex<\/li>\n<li>Designed for prolonged endocrine stimulation<\/li>\n<\/ul>\n<p><strong><a href=\"https:\/\/life-peptide.com\/de\/product\/cjc-1295-ohne-dac\/\">CJC-1295 ohne DAC<\/a> (Modified GRF 1-29)<\/strong><\/p>\n<ul>\n<li>Short-acting (approximately 30-minute half-life)<\/li>\n<li>Physiologische GH-Pulse<\/li>\n<li>Rapid clearance<\/li>\n<li>Designed to mimic natural GHRH secretion<\/li>\n<\/ul>\n<p>For this reason, the two peptides are not interchangeable and are often selected for different research objectives.<\/p>\n<h4><strong>Menschliche und pr\u00e4klinische Forschung<\/strong><\/h4>\n<p>CJC-1295 with DAC has progressed into early human clinical investigation.<\/p>\n<p>Published studies demonstrated prolonged increases in circulating growth hormone and IGF-1 following administration, confirming that the Drug Affinity Complex successfully extends biological activity compared with conventional GHRH analogues. Research continues to explore applications in endocrinology, metabolism and healthy aging.<\/p>\n<h4><strong>Ver\u00f6ffentlichte Sicherheitsbeobachtungen<\/strong><\/h4>\n<p>Early clinical studies generally reported <strong>gute Vertr\u00e4glichkeit<\/strong>. The most frequently reported adverse events included mild injection-site reactions and transient flushing. Researchers also noted prolonged elevations of GH and IGF-1 consistent with the peptide&#8217;s extended half-life, which distinguishes it from the shorter-acting No DAC formulation.<\/p>\n<hr \/>\n<h3><strong>Produkteigenschaften<\/strong><\/h3>\n<p>Anwendung: Labor- und analytische Forschung<br \/>\nVerwendungseinschr\u00e4nkung: Nicht zum menschlichen Verzehr bestimmt; nicht f\u00fcr medizinische, veterin\u00e4rmedizinische oder kosmetische Zwecke<br \/>\nHergestellt in GMP-konformen Anlagen unter strengen Qualit\u00e4tskontrollprotokollen.<br \/>\nJede Charge wird nach der Produktion sorgf\u00e4ltig im Labor getestet (das Analysezertifikat finden Sie unter den Produktbildern).<br \/>\nGefriergetrocknet (lyophilisiert) f\u00fcr maximale Stabilit\u00e4t und l\u00e4ngere Haltbarkeit.<br \/>\nSteril in Fl\u00e4schchen abgef\u00fcllt, bereit zur Rekonstitution.<br \/>\nPurity: \u2265 99.64% , HPLC tested<br \/>\nAussehen: wei\u00dfes lyophilisiertes Pulver<br \/>\nSummenformel: C<sub>165<\/sub>H<sub>269<\/sub>N<sub>47<\/sub>O<sub>46<\/sub><br \/>\nMolecular weight: 3647.65<\/p>\n<p><strong>Speicher<\/strong>unge\u00f6ffnete gefriergetrocknete Vials werden am besten gelagert <strong>gek\u00fchlte Lagerung bei 2\u20138\u00b0C<\/strong>, welche die von unserem Fertigungspartner best\u00e4tigte Lagerungsmethode ist und sich f\u00fcr bis zu 24 Monate eignet. K\u00fchlung wird bevorzugt, da sie unn\u00f6tige Gefrier-Tau-Zyklen bei routinem\u00e4\u00dfiger Handhabung minimiert. Wenn eine deutlich l\u00e4ngerfristige Lagerung erforderlich ist, k\u00f6nnen auch unge\u00f6ffnete gefriergetrocknete Vials gefroren aufbewahrt werden. Nach der Rekonstitution immer bei 2\u20138 \u00b0C lagern und nicht einfrieren.<\/p>\n<h4><strong>Rekonstitution und Handhabung<\/strong><\/h4>\n<p>CJC-1295 wird in einer gefriergetrockneten Durchstechflasche geliefert und sollte gem\u00e4\u00df den Standardverfahren f\u00fcr die Rekonstitution von Peptiden im Forschungsumfeld gehandhabt werden. Muss rekonstituiert werden mit <a href=\"https:\/\/life-peptide.com\/de\/product\/bac-10-ml\/\">Bakteriostatisches Wasser<\/a> Vor Gebrauch. Um die strukturelle Integrit\u00e4t zu erhalten, geben Sie das gew\u00e4hlte L\u00f6sungsmittel langsam an der Innenwand des Fl\u00e4schchens hinzu und nicht direkt auf den Peptidkuchen, und vermeiden Sie kr\u00e4ftiges Sch\u00fctteln. Sanftes Schwenken ist im Allgemeinen ausreichend, sobald sich das Peptid vollst\u00e4ndig gel\u00f6st hat. Standardm\u00e4\u00dfige Laborpraxis beinhaltet auch, gek\u00fchlte Fl\u00e4schchen Raumtemperatur erreichen zu lassen, bevor sie rekonstituiert werden, um die Kondensation im Fl\u00e4schchen zu minimieren.<\/p>\n<p>F\u00fcr weitere Informationen zur L\u00f6sungsmittelauswahl, zur Konzentrationsplanung und zur Lagerung siehe das vollst\u00e4ndige <a href=\"https:\/\/life-peptide.com\/de\/rekonstitution-von-peptiden\/\">Leitfaden zur Peptidrekonstitution<\/a> und <a href=\"https:\/\/life-peptide.com\/de\/taschenrechner\/\">Rekonstitutionsrechner<\/a>.<\/p>\n<hr \/>\n<h4><strong>Ausgew\u00e4hlte Referenzen<\/strong><\/h4>\n<ul>\n<li>Teichman SL, et al. <em>Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, Journal of Clinical Endocrinology &amp; Metabolism<\/em>, 2006<\/li>\n<\/ul>\n<p>The landmark first-in-human study demonstrating prolonged increases in GH and IGF-1 following administration of CJC-1295 with DAC.<\/p>\n<ul>\n<li>Drug Affinity Complex pharmacology<\/li>\n<\/ul>\n<p>Research describing albumin binding, extended half-life and pharmacokinetics of CJC-1295 with DAC compared with short-acting Modified GRF (1-29).<\/p>\n<ul>\n<li>Modern comparative reviews<\/li>\n<\/ul>\n<p>Recent reviews summarising the pharmacological differences between CJC-1295 with DAC and CJC-1295 No DAC, with emphasis on sustained versus pulsatile GH signalling.<\/p>\n<hr \/>\n<h4><strong>H\u00e4ufig gestellte Fragen<\/strong><\/h4>\n<p><strong>What is CJC-1295 with DAC?<\/strong><\/p>\n<p>CJC-1295 with DAC is a long-acting analogue of growth hormone-releasing hormone (GHRH). The attached Drug Affinity Complex extends its circulation time, making it widely investigated for sustained GH and IGF-1 signalling.<\/p>\n<p><strong>What does DAC mean?<\/strong><\/p>\n<p>DAC stands for Drug Affinity Complex, a chemical modification that enables reversible albumin binding and dramatically prolongs the peptide&#8217;s half-life.<\/p>\n<p><strong>How is CJC-1295 with DAC different from No DAC?<\/strong><\/p>\n<p>The DAC version provides prolonged GH and IGF-1 elevation, whereas CJC-1295 No DAC (Modified GRF 1-29) produces short-lived, physiological GH pulses. They are different research tools rather than different strengths of the same peptide.<\/p>\n<p><strong>Why is CJC-1295 with DAC investigated for IGF-1?<\/strong><\/p>\n<p>Its extended duration of action allows researchers to study sustained stimulation of the GH\/IGF-1 axis over several days rather than transient hormone pulses.<\/p>\n<p><strong>Can CJC-1295 with DAC be combined with other GH peptides?<\/strong><\/p>\n<p>In published research, CJC-1295 with DAC has often been discussed alongside peptides that stimulate growth hormone through complementary mechanisms, including Ipamorelin. The combination is investigated because the peptides act through different receptor systems, although each retains a distinct pharmacological profile.<\/p>\n<p><strong>Ist dieses Produkt f\u00fcr den menschlichen Gebrauch bestimmt?<\/strong><\/p>\n<p>No. CJC-1295 with DAC supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.<\/p>\n<hr \/>\n<h4><strong>Verwandter Forschungskontext<\/strong><\/h4>\n<p>CJC-1295 with DAC is frequently discussed alongside other research peptides investigating growth hormone signalling, recovery and healthy aging.<\/p>\n<p><a href=\"https:\/\/life-peptide.com\/de\/product\/cjc-1295-ohne-dac\/\"><strong>CJC-1295 ohne DAC<\/strong><\/a> (Modified GRF 1-29) \u2013 investigated for physiological pulsatile growth hormone release and short-duration GHRH signalling.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/ipamorelin-5-mg\/\"><strong>Ipamorelin<\/strong> <\/a>\u2013 studied as a selective ghrelin receptor agonist that stimulates endogenous growth hormone release through a complementary pathway.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/tesamorelin-10-mg\/\"><strong>Tesamorelin<\/strong> <\/a>\u2013 investigated as a clinically validated GHRH analogue with established endocrine research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/mots-c-10-mg\/\"><strong>MOTS-c<\/strong> <\/a>\u2013 focuses on mitochondrial metabolism, exercise adaptation and healthy aging rather than direct GH signalling.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/epitalon-10-mg\/\"><strong>Epitalon<\/strong> <\/a>\u2013 investigated for telomere biology, circadian regulation and longevity research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/ss-31\/\"><strong>SS-31<\/strong><\/a> \u2013 investigated for mitochondrial function and cellular bioenergetics.<\/p>\n<p>Although these peptides are often grouped within performance and healthy aging research, CJC-1295 with DAC is distinguished by its sustained activation of the growth hormone axis, whereas the others target different biological pathways.<\/p>\n<p><strong>ANMERKUNG<\/strong>Dies dient ausschlie\u00dflich zu Bildungszwecken und stellt keine medizinische Beratung dar.<\/p>\n<p><strong>Haftungsausschluss<\/strong><br \/>\nDieses Produkt wird ausschlie\u00dflich zu Forschungszwecken verkauft. Es ist nicht dazu bestimmt, Krankheiten zu diagnostizieren, zu behandeln, zu heilen oder zu verhindern. Der K\u00e4ufer \u00fcbernimmt die volle Verantwortung f\u00fcr die ordnungsgem\u00e4\u00dfe Handhabung und Verwendung.<\/p>","protected":false},"excerpt":{"rendered":"<p>CJC-1295 with DAC \/ 2 mg is a research-grade long-acting GHRH analogue supplied in lyophilised form for laboratory use. By incorporating a Drug Affinity Complex (DAC), it remains active for several days, making it one of the best-known peptides for sustained growth hormone and IGF-1 research.<\/p>\n<p>||<\/p>\n<p>Purity \u226599% | EU Shipping from \u20ac5 | Free shipping upgrades available | Card payments accepted<\/p>","protected":false},"featured_media":1273,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[21],"product_tag":[354,358,356,290,357,320,355,282],"class_list":["post-1274","product","type-product","status-publish","has-post-thumbnail","product_cat-growth-hormone-secretagogues","product_tag-cjc-1295-with-dac","product_tag-endocrine-research","product_tag-ghrh-analogue","product_tag-growth-hormone-peptide","product_tag-healthy-aging-peptide","product_tag-igf-1-research","product_tag-long-acting-ghrh","product_tag-recovery-peptide","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product\/1274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/comments?post=1274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/media\/1273"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/media?parent=1274"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product_brand?post=1274"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product_cat?post=1274"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product_tag?post=1274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}