{"id":246,"date":"2026-02-18T11:51:05","date_gmt":"2026-02-18T09:51:05","guid":{"rendered":"http:\/\/example.test\/?post_type=product&#038;p=246"},"modified":"2026-07-20T17:19:23","modified_gmt":"2026-07-20T14:19:23","slug":"kpv-5-mg","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/de\/product\/kpv-5-mg\/","title":{"rendered":"KPV 5 mg"},"content":{"rendered":"<p>KPV (Lys-Pro-Val) is a naturally occurring <strong>three-amino-acid fragment of \u03b1-melanocyte-stimulating hormone (\u03b1-MSH)<\/strong>. Despite its small size, it retains much of the parent hormone&#8217;s <strong>anti-inflammatory activity<\/strong> while lacking the pigmentation effects associated with full-length \u03b1-MSH.<\/p>\n<p>Unlike many immune-modulating peptides, KPV appears to <strong>regulate inflammatory signalling without broadly suppressing immune function<\/strong>. This has made it one of the most interesting investigational peptides for research involving inflammatory diseases, epithelial barrier function and mucosal immunity.<\/p>\n<hr \/>\n<h4><strong>Why KPV is widely investigated<\/strong><\/h4>\n<p>Published research has investigated KPV in relation to:<\/p>\n<ul>\n<li><strong>immune regulation<\/strong><\/li>\n<li><strong>entz\u00fcndliche Signal\u00fcbertragung<\/strong><\/li>\n<li><strong>gut health research<\/strong><\/li>\n<li><strong>intestinal barrier function<\/strong><\/li>\n<li><strong>skin inflammation<\/strong><\/li>\n<li><strong>epithelial biology<\/strong><\/li>\n<li><strong>Wundheilung<\/strong><\/li>\n<li><strong>mucosal immunity<\/strong><\/li>\n<li><strong>NF-\u03baB signalling<\/strong><\/li>\n<\/ul>\n<p>Because of its small size and unique mechanism, KPV has become one of the best-known research peptides targeting inflammatory pathways rather than structural tissue repair.<\/p>\n<h4><strong>How KPV works<\/strong><\/h4>\n<p>Unlike BPC-157 or TB-500, KPV is primarily investigated for its effects on <strong>immune signalling<\/strong> rather than tissue regeneration.<\/p>\n<p>Ver\u00f6ffentlichte Forschung hat dessen Zusammenhang untersucht mit:<\/p>\n<p><strong>Inflammatory signalling<\/strong><\/p>\n<p>KPV has been widely investigated for its ability to reduce activation of inflammatory pathways including NF-\u03baB, resulting in lower production of multiple pro-inflammatory mediators in experimental models.<\/p>\n<p><strong>Gut barrier research<\/strong><\/p>\n<p>One of the largest areas of investigation focuses on intestinal epithelial cells and experimental models of inflammatory bowel disease, where KPV has demonstrated effects on epithelial integrity and inflammatory signalling.<\/p>\n<p><strong>Skin biology<\/strong><\/p>\n<p>Researchers have also explored KPV in models of inflammatory skin conditions and wound repair because of its effects on epithelial tissues.<\/p>\n<p><strong>Immunmodulation<\/strong><\/p>\n<p>Current evidence suggests that KPV modulates immune responses rather than producing broad immunosuppression, making it an interesting candidate for studies of physiological inflammatory regulation.<\/p>\n<hr \/>\n<h4><strong>Why KPV is becoming increasingly important<\/strong><\/h4>\n<p>Interest in KPV has increased significantly over the last several years because it represents a different approach to inflammation research.<\/p>\n<p>Rather than focusing primarily on structural tissue repair like <a href=\"https:\/\/life-peptide.com\/de\/product\/bpc-157-5-mg\/\">BPC-157<\/a> or systemic regeneration like <a href=\"https:\/\/life-peptide.com\/de\/product\/thymosin-%ce%b24-1-43-vollstandige-sequenz-5-mg\/\">TB-500<\/a>, KPV investigates the <strong>signalling pathways that initiate and maintain inflammation<\/strong>.<\/p>\n<p>This complementary biology has made KPV increasingly popular in research involving inflammatory bowel disease, skin biology and epithelial barrier function.<\/p>\n<h4><strong>Menschliche und pr\u00e4klinische Forschung<\/strong><\/h4>\n<p>Most published evidence for KPV comes from cell culture and animal models.<\/p>\n<p>Research has consistently investigated inflammatory signalling in the gut, skin, lungs and epithelial tissues, while human clinical evidence remains limited. Although the preclinical data are encouraging, additional human research is required before conclusions can be drawn regarding clinical applications.<\/p>\n<h4><strong>Ver\u00f6ffentlichte Sicherheitsbeobachtungen<\/strong><\/h4>\n<p>Current knowledge of KPV is derived predominantly from laboratory and preclinical research. Published studies generally report favourable tolerability in experimental models, but controlled human clinical evidence remains limited. As with many emerging research peptides, additional studies are needed to fully characterise long-term efficacy and safety.<\/p>\n<hr \/>\n<h4><strong>Produkteigenschaften<\/strong><\/h4>\n<p>Anwendung: Labor- und analytische Forschung<br \/>\nVerwendungseinschr\u00e4nkung: Nicht zum menschlichen Verzehr bestimmt; nicht f\u00fcr medizinische, veterin\u00e4rmedizinische oder kosmetische Zwecke<br \/>\nHergestellt in GMP-konformen Anlagen unter strengen Qualit\u00e4tskontrollprotokollen.<br \/>\nJede Charge wird nach der Produktion sorgf\u00e4ltig im Labor getestet (das Analysezertifikat finden Sie unter den Produktbildern).<br \/>\nGefriergetrocknet (lyophilisiert) f\u00fcr maximale Stabilit\u00e4t und l\u00e4ngere Haltbarkeit.<br \/>\nSteril in Fl\u00e4schchen abgef\u00fcllt, bereit zur Rekonstitution.<br \/>\nReinheit: \u226599,1 % (HPLC-gepr\u00fcft)<br \/>\nAussehen: Lyophilisiertes wei\u00dfes\/wei\u00dfliches Pulver<br \/>\nSummenformel: C<sub>16<\/sub>H<sub>30<\/sub>N<sub>4<\/sub>O<sub>4<\/sub><br \/>\nMolekulargewicht: 342,43<br \/>\nLys-Pro-Val<br \/>\nLagerung: Unge\u00f6ffnete lyophilysierte Fl\u00e4schchen werden am besten gek\u00fchlt bei 2\u20138 \u00b0C gelagert, was die von unserem Produktionspartner best\u00e4tigte Lagerungsmethode ist und f\u00fcr bis zu 24 Monate geeignet ist. K\u00fchlung wird bevorzugt, da sie unn\u00f6tige Gefrier-Tau-Zyklen bei der routinem\u00e4\u00dfigen Handhabung minimiert. Wenn eine wesentlich l\u00e4ngerfristige Lagerung erforderlich ist, k\u00f6nnen unge\u00f6ffnete lyophilysierte Fl\u00e4schchen auch gefroren aufbewahrt werden. Nach der Rekonstitution immer bei 2\u20138 \u00b0C lagern und nicht einfrieren.<\/p>\n<h4><strong>Rekonstitution und Handhabung<\/strong><\/h4>\n<p>KPV\u00a0 is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with <a href=\"https:\/\/life-peptide.com\/de\/product\/bac-10-ml\/\">Bakteriostatisches Wasser<\/a> Vor Gebrauch. Um die strukturelle Integrit\u00e4t zu erhalten, geben Sie das gew\u00e4hlte L\u00f6sungsmittel langsam an der Innenwand des Fl\u00e4schchens hinzu und nicht direkt auf den Peptidkuchen, und vermeiden Sie kr\u00e4ftiges Sch\u00fctteln. Sanftes Schwenken ist im Allgemeinen ausreichend, sobald sich das Peptid vollst\u00e4ndig gel\u00f6st hat. Standardm\u00e4\u00dfige Laborpraxis beinhaltet auch, gek\u00fchlte Fl\u00e4schchen Raumtemperatur erreichen zu lassen, bevor sie rekonstituiert werden, um die Kondensation im Fl\u00e4schchen zu minimieren.<\/p>\n<p>F\u00fcr weitere Informationen zur L\u00f6sungsmittelauswahl, zur Konzentrationsplanung und zur Lagerung siehe das vollst\u00e4ndige <a href=\"https:\/\/life-peptide.com\/de\/rekonstitution-von-peptiden\/\">Leitfaden zur Peptidrekonstitution<\/a> und <a href=\"https:\/\/life-peptide.com\/de\/taschenrechner\/\">Rekonstitutionsrechner<\/a>.<\/p>\n<hr \/>\n<h4><strong>Ausgew\u00e4hlte Referenzen<\/strong><\/h4>\n<ul>\n<li>Dalmasso G, et al. <em>PepT1-Mediated Uptake of the Tripeptide KPV Reduces Intestinal Inflammation, Molecular Therapy<\/em>, 2011<\/li>\n<\/ul>\n<p>A landmark study demonstrating epithelial uptake of KPV and reduced inflammatory signalling in experimental intestinal inflammation.<\/p>\n<ul>\n<li>Kannengiesser K, et al. <em>KPV Protects Against Experimental Colitis Through Modulation of Inflammatory Pathways, Gastroenterology Research<\/em>, 2017<\/li>\n<\/ul>\n<p>Research demonstrating protective effects of KPV in experimental inflammatory bowel disease models.<\/p>\n<ul>\n<li>Brzoska T, Luger TA, et al. <em>Alpha-MSH and the C-Terminal Tripeptide KPV in Inflammation, Journal of Investigative Dermatology<\/em>, 2003<\/li>\n<\/ul>\n<p>A foundational review explaining why the KPV fragment retains potent anti-inflammatory activity despite lacking the full \u03b1-MSH sequence.<\/p>\n<ul>\n<li>Merlin D, et al. <em>KPV and Epithelial Immune Regulation, Various publications<\/em><\/li>\n<\/ul>\n<p>A series of studies exploring KPV transport through PepT1 and regulation of epithelial inflammatory signalling.<\/p>\n<hr \/>\n<h4><strong>H\u00e4ufig gestellte Fragen<\/strong><\/h4>\n<p><strong>What is KPV?<\/strong><\/p>\n<p>KPV is a naturally occurring tripeptide derived from \u03b1-melanocyte-stimulating hormone (\u03b1-MSH). It is widely investigated for immune regulation, inflammatory signalling and epithelial barrier research.<\/p>\n<p><strong>Why is KPV different from BPC-157?<\/strong><\/p>\n<p>Although both peptides are frequently discussed in recovery research, BPC-157 is primarily investigated for tissue repair, whereas KPV focuses on immune regulation and inflammatory signalling. Their biological targets are complementary rather than identical.<\/p>\n<p><strong>Why is KPV associated with gut health research?<\/strong><\/p>\n<p>Much of the published literature has investigated KPV in intestinal epithelial cells and experimental models of inflammatory bowel disease because of its effects on inflammatory signalling and epithelial barrier function.<\/p>\n<p><strong>What research areas commonly investigate KPV?<\/strong><\/p>\n<p>Current research includes immune regulation, gut inflammation, epithelial biology, wound healing, skin inflammation, mucosal immunity and inflammatory signalling.<\/p>\n<p><strong>Does KPV work through melanocortin receptors?<\/strong><\/p>\n<p>Current evidence suggests that many of KPV&#8217;s anti-inflammatory effects occur independently of classical melanocortin receptor signalling, making it mechanistically distinct from full-length \u03b1-MSH.<\/p>\n<p><strong>Ist dieses Produkt f\u00fcr den menschlichen Gebrauch bestimmt?<\/strong><\/p>\n<p>No. KPV supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the scientific literature relating to the KPV molecule rather than the intended use of this product.<\/p>\n<hr \/>\n<h4><strong>Verwandter Forschungskontext<\/strong><\/h4>\n<p>KPV geh\u00f6rt zur <a href=\"\/de\/kategorie\/heilpeptide\/\">Heilungs- und Erholungspeptid-Forschung Kategorie<\/a>, with a stronger focus on inflammatory signaling and epithelial pathway investigation. KPV is frequently discussed alongside other research peptides investigating immune regulation, tissue repair and recovery:<\/p>\n<p><a href=\"https:\/\/life-peptide.com\/de\/product\/bpc-157-5-mg\/\"><strong>BPC-157<\/strong> <\/a>\u2013 investigated primarily for tissue repair, tendon biology and angiogenesis.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/thymosin-%ce%b24-1-43-vollstandige-sequenz-5-mg\/\"><strong>TB-500<\/strong> <\/a>(Thymosin \u03b24) \u2013 studied for cell migration, regeneration and wound healing.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/glow-ghk-cu-50-mg-bpc-157-10-mg-und-tb-500-10-mg\/\"><strong>Glow Blend<\/strong><\/a> \u2013 combines GHK-Cu, BPC-157 and TB-500 for multi-pathway recovery research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/bpc-157-tb-500-5-mg-5-mg-wolverine\/\"><strong>Wolverine Mischung<\/strong><\/a> \u2013 combines BPC-157 and TB-500 for connective tissue and regeneration studies.<br \/>\n<a href=\"https:\/\/life-peptide.com\/de\/product\/ghk-cu-50-mg\/\"><strong>GHK-Cu<\/strong><\/a> \u2013 investigated in skin biology, extracellular matrix remodelling and wound repair.<\/p>\n<p>Although these peptides are often grouped within recovery research, KPV stands apart by focusing primarily on immune regulation and inflammatory signalling rather than structural tissue regeneration.<br \/>\nF\u00fcr breiteren Kontext siehe die <a href=\"\/de\/heilungs-und-genesungsforschung-leitfaden\/\">Leitfaden f\u00fcr Forschung zu Heilung und Genesung<\/a>.<\/p>\n<p><strong>HINWEIS: <\/strong>Dies dient nur zu Bildungszwecken und stellt keine medizinische Beratung dar.<\/p>\n<p><strong>Haftungsausschluss<\/strong><br \/>\nDieses Produkt wird ausschlie\u00dflich zu Forschungszwecken verkauft. Es ist nicht dazu bestimmt, Krankheiten zu diagnostizieren, zu behandeln, zu heilen oder zu verhindern. Der K\u00e4ufer \u00fcbernimmt die volle Verantwortung f\u00fcr die ordnungsgem\u00e4\u00dfe Handhabung und Verwendung.<\/p>","protected":false},"excerpt":{"rendered":"<p>KPV 5 mg is a research-grade tripeptide supplied in lyophilised form for laboratory use. Derived from \u03b1-melanocyte-stimulating hormone (\u03b1-MSH), it is one of the most extensively investigated peptides for immune regulation, inflammatory signalling and epithelial barrier research, with growing interest in gut, skin and mucosal biology.<\/p>\n<p>||<\/p>\n<p>Purity \u226599% | EU shipping from \u20ac5 | Free shipping upgrades available | Card payments accepted<\/p>","protected":false},"featured_media":247,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[20],"product_tag":[343,205,206,344,196,208,342,282,200],"class_list":["post-246","product","type-product","status-publish","has-post-thumbnail","product_cat-healing-peptides","product_tag-anti-inflammatory-peptide","product_tag-cytokine-signaling","product_tag-epithelial-barrier","product_tag-gut-health-research","product_tag-gut-peptide","product_tag-gut-research-peptide","product_tag-immune-regulation","product_tag-recovery-peptide","product_tag-tissue-signaling","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product\/246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/comments?post=246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/media\/247"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/media?parent=246"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product_brand?post=246"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product_cat?post=246"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/de\/wp-json\/wp\/v2\/product_tag?post=246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}