{"id":568,"date":"2026-03-02T16:19:02","date_gmt":"2026-03-02T14:19:02","guid":{"rendered":"http:\/\/example.test\/?page_id=568"},"modified":"2026-03-25T10:58:50","modified_gmt":"2026-03-25T08:58:50","slug":"dpp-4-degradation-peptide-engineering","status":"publish","type":"page","link":"https:\/\/life-peptide.com\/el\/dpp-4-degradation-peptide-engineering\/","title":{"rendered":"\u03a5\u03c0\u03bf\u03b2\u03ac\u03b8\u03bc\u03b9\u03c3\u03b7 DPP-4 \u03ba\u03b1\u03b9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b7\u03c2"},"content":{"rendered":"<h1 class=\"wp-block-heading has-text-align-center\"><strong>\u03a5\u03c0\u03bf\u03b2\u03ac\u03b8\u03bc\u03b9\u03c3\u03b7 DPP-4 \u03ba\u03b1\u03b9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b7\u03c2<\/strong><\/h1>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\"><strong>\u0395\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf GLP-1<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03b9\u03bd\u03ba\u03c1\u03b9\u03c4\u03af\u03bd\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf GLP-1 \u03ba\u03b1\u03b9 \u03c4\u03bf GIP, \u03b1\u03c0\u03bf\u03b4\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1\u03c7\u03ad\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03c5\u03bb\u03bf\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7-4 (DPP-4), \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03bf\u03c5\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2. \u03a3\u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1, \u03b7 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03b2\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1\u03c2 \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 DPP-4 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03b7\u03bc\u03afz\u03c9\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u05d4\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0395\u03b3\u03b3\u03b5\u03bd\u03ad\u03c2 GLP-1<\/li>\n\n\n\n<li>\u0391\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd GLP-1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 (\u03c0.\u03c7. \u03c3\u03b5\u03bc\u03b1\u03b3LUTIDE)<\/li>\n\n\n\n<li>\u0394\u03b9\u03c0\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b9\u03c0\u03bb\u03ac \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd, \u03b2\u03bb\u03ad\u03c0\u03b5 <strong><a href=\"\/el\/glp-1-metabolic-research-guide\/\" data-type=\"page\" data-id=\"529\">\u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf GLP-1.<\/a><\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u0395\u03b3\u03b3\u03b5\u03bd\u03ad\u03c2 GLP-1 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7 \u03b1\u03c0\u03cc DPP-4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 GLP-1 (7\u201336 \u03b1\u03bc\u03af\u03b4\u03b9\u03bf) \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b1\u03c7\u03ad\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd DPP-4, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c0\u03ac \u03c4\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 2 (His-Ala). \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c0\u03bf\u03ba\u03bf\u03bc\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 GLP-1 (9\u201336), \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 (Mentlein et al., 1993\u00b7 Holst, 2007).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039f \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03af\u03bc\u03b9\u03c3\u03b7\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2 GLP-1 \u03b5\u03af\u03bd\u03b1\u03b9 \u2248 1\u20132 \u03bb\u03b5\u03c0\u03c4\u03ac<\/li>\n\n\n\n<li>\u0397 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7<\/li>\n\n\n\n<li>\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c1\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c3\u03b9\u03ba\u03bf\u03cd GLP-1 \u03c3\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03bd\u03b6ym\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DPP-4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 DPP-4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b5\u03c1\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03c3\u03b5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1. \u03a5\u03c0\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03b7\u03c3\u03b9\u03b1\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c0\u03ac \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03bb\u03af\u03bd\u03b7 \u03ae \u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5 \u039d-\u03c4\u03b5\u03bb\u03b9\u03ba\u03bf\u03cd (Deacon, 2019).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7\u03bd \u03b9\u03bd\u03ba\u03c1\u03b9\u03c4\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">GLP-1: His-Ala \u2193<br>GIP: Tyr-Ala \u2193<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03c4\u03cc\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1, \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03cd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5, \u03b7 \u03b1\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 DPP-4 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c0\u03c1\u03c9\u03c4\u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u0394\u03b9\u03b1\u03c1\u03b8\u03c1\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3ige\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 DPP-4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b9\u03bd\u03ba\u03c1\u03b9\u03c4\u03b9\u03bd\u03ce\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u0391. \u0391\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03bf\u03c2<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b1\u03bd\u03c4\u03b9\u03baat\u03b1\u03c3t\u03b1\u03c3h \u03c4\u03b7\u03c3 al\u03b1\u03bd\u03b9\u03bd\u03b7\u03c3 st\u03b7 \u03b8\u03b5\u03c2h 2 \u03bc\u03b5 \u03b5\u03bd\u03b1 \u03bc\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03b9\u03bc\u03bf \u03ba\u03b1\u03c4\u03b1\u03bb\u03bf\u03b9\u03c0\u03bf \u03bc\u03b5\u03b9\u03c9\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c1\u03c1\u03b5\u03c0\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c3\u03c0\u03b1\u03c3\u03b7 \u03b1\u03c0\u03bf \u03c4\u03b7\u03bd DPP-4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1:<br>\u0397 \u03c3\u03b5\u03bc\u03b1\u03b3\u03bb\u03bf\u03c5\u03c4\u03af\u03b4\u03b7 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03cd \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 8, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 (Lau et al., 2015).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u0392. \u03a3\u03c5\u03b6\u03b5\u03cd\u03be\u03b5\u03b9\u03c2 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd (\u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7)<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 \u03bb\u03b9\u03c0\u03b1\u03c1\u03bf\u03cd C18 \u03b4\u03b9\u03b1\u03be\u03ad\u03bf\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03bd\u03cc\u03c2 \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7<\/li>\n\n\n\n<li>\u03a0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7<\/li>\n\n\n\n<li>\u03a0\u03b1\u03c1\u03b1\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03af\u03c3\u03b5\u03b9\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c3\u03b5\u03bc\u03b1\u03b3LUTID\u0397 \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03ba\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03cd\u03c7\u03b5\u03b9 \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03bc\u03b9\u03b1\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 (Lau et al., 2015; Knudsen &amp; Lau, 2019).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u0393. \u03a3\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7 &amp; \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b8\u03c9\u03c1\u03ac\u03ba\u03b9\u03c3\u03b7<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b5\u03c2 \u03bf\u03b3\u03ba\u03c9\u03b4\u03ce\u03bd \u03c0\u03bb\u03b5\u03c5\u03c1\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03b4\u03b9\u03ac\u03c4\u03b1\u03be\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b2\u03b1\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd<\/li>\n\n\n\n<li>\u0392\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/li>\n\n\n\n<li>\u03a4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b4\u03b9\u03c0\u03bb\u03bf\u03af \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b9\u03c0\u03bb\u03bf\u03af \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2 \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u03a3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03c0\u03bb\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b9\u03c0\u03bb\u03bf\u03cd\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c4\u03b9\u03c1\u03b6\u03b5\u03c0\u03b1\u03c4\u03af\u03b4\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c1\u03b5\u03c4\u03b1\u03c4\u03c1\u03c5\u03c4\u03af\u03b4\u03b7 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd \u03b4\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03c7\u03c5\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf DPP-4, \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03a4\u03b9\u03c1\u03b6\u03b5\u03c0\u03b1\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0391\u03bc\u03b9\u03bd\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/li>\n\n\n\n<li>\u03a3\u03c5\u03b6\u03b5\u03cd\u03be\u03b5\u03b9\u03c2 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7<\/li>\n\n\n\n<li>\u03a4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03cd\u03c1\u03b9\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bc\u03bf\u03cd<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391ta \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bc\u03af\u03b1\u03c2 \u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c3\u03b5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 (Frias et al., 2021).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c4\u03c1\u03b9\u03c0\u03bb\u03ad\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2, \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 (Jastreboff et al., 2023).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03b7\u03bc\u03af\u03c3\u03b5\u03b9\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/li>\n\n\n\n<li>\u03a0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03af\u03b1 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/li>\n\n\n\n<li>\u03a0\u03b9\u03bf \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1<\/li>\n\n\n\n<li>\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03c9\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03c0\u03bf\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a6\u03c5\u03c3\u03b9\u03ba\u03cc GLP-1 = \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2<\/li>\n\n\n\n<li>\u03a4\u03b5\u03c7\u03bd\u03b7\u03c4\u03ac \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 = \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u0394\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b9\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2. \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7 \u03b1\u03c6\u03b8\u03bf\u03bd\u03b5\u03af \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1, \u03c4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03bc\u03b5 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ad\u03c2 \u03b1\u03ba\u03c5\u03bb\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd \u03b4\u03b5\u03be\u03b1\u03bc\u03b5\u03bd\u03ad\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c1\u03b3\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b9\u03c4\u03b9\u03bd\u03ce\u03bd (Knudsen &amp; Lau, 2019).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/el\/product\/semaglutide-10-mg\/\" data-type=\"product\" data-id=\"303\">Semaglutide <\/a>\u03b1\u03bd \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03be\u03b5\u03bb\u03b9\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c3\u03c4\u03ce\u03bd GLP-1.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \u03a3\u03cd\u03b3\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u03a3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<\/strong><\/td><td><strong>\u03a3\u03ba\u03bf\u03c0\u03cc\u03c2<\/strong><\/td><td><strong>\u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u0395\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u0391\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03bf\u03c2<\/td><td>\u0391\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc DPP-4<\/td><td>\u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c4\u03bf\u03c5 GLP-1<\/td><\/tr><tr><td>\u03a3\u03c5\u03b6\u03b5\u03c5\u03b3\u03ae \u03bb\u03b9\u03c0\u03b1\u03c1\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd<\/td><td>\u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03b7\u03bc\u03af\u03c3\u03b5\u03b9\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2<\/td><td><a href=\"\/el\/product\/semaglutide-10-mg\/\" data-type=\"product\" data-id=\"303\">Semaglutide<\/a><\/td><\/tr><tr><td>\u03a4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b7\u03c2<\/td><td>\u03a3\u03b8\u03b5\u03bd\u03bf\u03c4\u03ae\u03c4\u03b1 &amp; \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/td><td>\u0394\u03b9\u03c0\u03bb\u03bf\u03af\/\u03c4\u03c1\u03b9\u03c0\u03bb\u03bf\u03af \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2<\/td><\/tr><tr><td>\u03a3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/td><td>\u0395\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03c9\u03bd \u03c3\u03c5\u03bd\u03b1\u03b3\u03b5\u03c1\u03bc\u03cc\u03c2<\/td><td><a href=\"\/el\/product\/tirzepatide-10-mg\/\" data-type=\"product\" data-id=\"309\">\u03a4\u03b9\u03c1\u03b6\u03b5\u03c0\u03b1\u03c4\u03af\u03b4\u03b7<\/a>, <a href=\"\/el\/product\/retatrutide-10-mg\/\" data-type=\"product\" data-id=\"331\">\u03a1\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c5\u03c4\u03af\u03b4\u03b7<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8. \u03a0\u03b1r\u03b1\u03bc\u03b5\u03c4r\u03bf\u03af \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03b5\u03c1\u03b3\u03ac\u03b6\u03b5\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b7\u03c2:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c8\u03c5\u03c7\u03c1\u03ae \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 (2\u20138\u00b0C)<\/li>\n\n\n\n<li>\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5\u03c2 \u03c8\u03cd\u03be\u03b7\u03c2-\u0623\u03c0\u03cc\u03c8\u03c5\u03be\u03b7\u03c2<\/li>\n\n\n\n<li>\u0391\u03bd\u03b1\u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c5\u03c0\u03cc \u03b1\u03c0\u03bf\u03c3\u03c4\u03b5\u03b9\u03c1\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2<\/li>\n\n\n\n<li>\u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1ok\u03b9\u03bd_itik_\u03ae \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf\u03c5<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03bd\u03c4\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9. \u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0393\u03b9\u03b1\u03c4\u03af \u03c5\u03c0\u03bf\u03b2\u03b1\u03b8\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03c4\u03bf \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc GLP-1;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf DPP-4 \u03b4\u03b9\u03b1\u03c3\u03c0\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03c4\u03bf N-\u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b4\u03b9\u03c0\u03c4\u03b9\u03c0\u03af\u03b4\u03b9\u03bf, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03cc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03ce\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c3\u03b5\u03bc\u03b1\u03b3LUTID\u0397 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03ad\u03c3\u03c9 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b6\u03b5\u03cd\u03be\u03b7\u03c2 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03bf\u03b9 \u03b4\u03b9\u03c0\u03bb\u03bf\u03af \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b9\u03c0\u03bb\u03bf\u03af \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2;<\/strong> \u039d\u03b1\u03b9. \u0395\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd \u03b4\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2, \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10. \u03a3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"\/el\/product\/semaglutide-10-mg\/\" data-type=\"product\" data-id=\"303\">Semaglutide <\/a>(\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 GLP-1)<\/li>\n\n\n\n<li><a href=\"\/el\/product\/tirzepatide-10-mg\/\" data-type=\"product\" data-id=\"309\">\u03a4\u03b9\u03c1\u03b6\u03b5\u03c0\u03b1\u03c4\u03af\u03b4\u03b7 <\/a>(\u0394\u03b9\u03c0\u03bb\u03cc\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 GLP-1\/GIP)<\/li>\n\n\n\n<li><a href=\"\/el\/product\/retatrutide-10-mg\/\" data-type=\"product\" data-id=\"331\">\u03a1\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c5\u03c4\u03af\u03b4\u03b7 <\/a>(\u03a4\u03c1\u03b9\u03c0\u03bb\u03cc\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 GLP-1\/GIP\/\u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd <strong><a href=\"https:\/\/life-peptide.com\/el\/glp-1-metabolic-research-guide\/\" data-type=\"page\" data-id=\"529\">\u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1<\/a>.<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ad\u03c2<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Mentlein R et al. \u0397 \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03c5\u03bb\u03bf-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7 IV \u03c5\u03b4\u03c1\u03bf\u03bb\u03cd\u03b5\u03b9 \u03c4\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03cc \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf-1 \u03c0\u03bf\u03c5 \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7. <em>\u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03cc\u03c2 \u0394\u03bf\u03ba\u03af\u03bc\u03b9\u03bf\u03c2 \u0392\u03b9\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1\u03c2<\/em>. 1993.<br>Holst JJ. \u0397 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5-1 \u03c4\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2. <em>Physiological Reviews<\/em>. 2007.<br>Deacon CF. \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 DPP-4. <em>Frontiers in Endocrinology<\/em>. 2019.<br>Lau J et al. Discovery of the Once-Weekly GLP-1 Analogue Semaglutide. <em>Journal of Medicinal Chemistry<\/em>. 2015.<br>Knudsen LB, Lau J. \u0397 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b9\u03c1\u03b1\u0563\u056c\u03bf\u03c5\u03c4\u03af\u03b4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c3\u03b5\u03bc\u03b1\u03b3\u056c\u03bf\u03c5\u03c4\u03af\u03b4\u03b7\u03c2. <em>Frontiers in Endocrinology<\/em>. 2019.<br>Frias JP \u03ba.\u03ac. \u03a4\u03b9\u03c1\u03b6\u03b5\u03c0\u03b1\u03c4\u03af\u03b4\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03a3\u03b5\u03bc\u03b1\u03b3\u03bb\u03bf\u03c5\u03c4\u03af\u03b4\u03b7\u03c2 \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c3\u03c4\u03bf\u03bd \u0394\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2. <em>\u039d\u0395\u03a4\u0396\u039c<\/em>. 2021.<br>Jastreboff AM et al. \u0391\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c1\u03b9\u03c0\u03bb\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 Retatrutide. <em>\u039d\u0395\u03a4\u0396\u039c<\/em>. 2023.<\/p>","protected":false},"excerpt":{"rendered":"<p>DPP-4 degradation and structural engineering in incretin analogues Enzymatic instability and half-life extension strategies in GLP-1 research Native incretin hormones such as GLP-1 and GIP are rapidly degraded in circulation by the enzyme dipeptidyl peptidase-4 (DPP-4), resulting in extremely short biological half-lives. In metabolic research, structural peptide engineering is used to overcome this rapid enzymatic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-568","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/pages\/568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/comments?post=568"}],"version-history":[{"count":4,"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/pages\/568\/revisions"}],"predecessor-version":[{"id":611,"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/pages\/568\/revisions\/611"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/el\/wp-json\/wp\/v2\/media?parent=568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}