{"id":252,"date":"2026-02-18T11:57:01","date_gmt":"2026-02-18T09:57:01","guid":{"rendered":"http:\/\/example.test\/?post_type=product&#038;p=252"},"modified":"2026-08-25T10:26:00","modified_gmt":"2026-08-25T07:26:00","slug":"mots-c-10-mg","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/fr\/product\/mots-c-10-mg\/","title":{"rendered":"MOTS-c 10 mg"},"content":{"rendered":"<p>MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring 16-amino-acid mitochondrial-derived peptide encoded by mitochondrial DNA rather than the nuclear genome. This unique origin distinguishes it from most other research peptides and has made it an important molecule for investigating how mitochondria communicate with the rest of the cell.<\/p>\n<p>Published research suggests that MOTS-c is released in response to <strong>metabolic stress and exercise<\/strong>, where it helps coordinate cellular adaptation to increased energy demand. Because of this role, MOTS-c has become one of the leading investigational peptides in <strong>metabolism, exercise physiology and healthy aging research<\/strong>.<\/p>\n<p><em>Looking to buy MOTS-c in Europe? LIFE Peptide supplies high-purity MOTS-c for laboratory research with reliable EU-wide shipping.<\/em><\/p>\n<hr \/>\n<h4><strong>Why MOTS-c is widely investigated<\/strong><\/h4>\n<p>Published research has investigated MOTS-c in relation to:<\/p>\n<ul>\n<li><strong>cellular energy metabolism<\/strong><\/li>\n<li><strong>exercise adaptation<\/strong><\/li>\n<li><strong>fonction mitochondriale<\/strong><\/li>\n<li><strong>metabolic flexibility<\/strong><\/li>\n<li><strong>sensibilit\u00e9 \u00e0 l'insuline<\/strong><\/li>\n<li><strong>glucose metabolism<\/strong><\/li>\n<li><strong>vieillissement en sant\u00e9<\/strong><\/li>\n<li><strong>skeletal muscle physiology<\/strong><\/li>\n<li><strong>AMPK signalling<\/strong><\/li>\n<\/ul>\n<p>As research into mitochondrial-derived peptides has expanded, MOTS-c has become one of the best-characterised molecules linking mitochondrial function with whole-body metabolism.<\/p>\n<h4><strong>How MOTS-c works<\/strong><\/h4>\n<p>Unlike conventional peptide hormones, MOTS-c functions as a <strong>mitochondrial signalling peptide<\/strong>, helping cells adapt to metabolic stress.<\/p>\n<p>Les recherches publi\u00e9es ont explor\u00e9 sa relation avec :<\/p>\n<p><strong>Cellular energy metabolism<\/strong><\/p>\n<p>MOTS-c has been investigated for its ability to regulate cellular energy use during metabolic stress by influencing pathways involved in glucose utilisation and fatty acid metabolism.<\/p>\n<p><strong>Exercise adaptation<\/strong><\/p>\n<p>Exercise increases endogenous MOTS-c expression, making it one of the most studied mitochondrial-derived peptides in exercise physiology. Researchers have investigated whether MOTS-c contributes to some of the metabolic adaptations normally associated with physical activity.<\/p>\n<p><strong>AMPK signalling<\/strong><\/p>\n<p>One of the principal mechanisms investigated for MOTS-c involves activation of AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance and metabolic adaptation.<\/p>\n<p><strong>Vieillir en sant\u00e9<\/strong><\/p>\n<p>Because mitochondrial function changes with age, MOTS-c has become an important research target in studies investigating metabolic resilience and healthy aging.<\/p>\n<h4><strong>Why MOTS-c is often described as an &#8220;exercise peptide&#8221;<\/strong><\/h4>\n<p>One of the most interesting observations in the scientific literature is that endogenous MOTS-c levels increase in response to exercise.<\/p>\n<p>Rather than replacing physical activity, researchers are investigating whether MOTS-c activates some of the same cellular pathways involved in <strong>exercise-induced metabolic adaptation<\/strong>, particularly those related to <strong>mitochondrial function and AMPK signalling<\/strong>. This has led to its description as a potential exercise-mimetic peptide, although this remains an active area of research and should not be interpreted as equivalent to the physiological effects of exercise itself.<\/p>\n<hr \/>\n<h4><strong>Recherche humaine et pr\u00e9clinique<\/strong><\/h4>\n<p>Research on MOTS-c is growing rapidly, although the evidence base remains considerably smaller than for established metabolic peptides such as Semaglutide or Tirzepatide.<\/p>\n<p>Published studies have investigated MOTS-c in laboratory models of metabolism, exercise physiology, insulin sensitivity and aging, while human research has primarily focused on endogenous MOTS-c levels and their relationship with metabolic health. Clinical interventional research remains limited.<\/p>\n<h4><strong>How MOTS-c differs from related metabolic peptides<\/strong><\/h4>\n<table style=\"height: 172px;\" width=\"883\">\n<thead>\n<tr>\n<th>Peptide<\/th>\n<th>Primary research focus<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>MOTS-c<\/strong><\/td>\n<td>Mitochondrial metabolism &amp; exercise adaptation<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/life-peptide.com\/fr\/product\/ss-31\/\"><strong>SS-31 (Elamipretide)<\/strong><\/a><\/td>\n<td>Mitochondrial membrane function<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/life-peptide.com\/fr\/product\/retatrutide-10-mg\/\"><strong>Retatrutide<\/strong><\/a><\/td>\n<td>Triple incretin metabolic signalling<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/life-peptide.com\/fr\/product\/semaglutide-10-mg\/\"><strong>S\u00e9maglutide<\/strong><\/a><\/td>\n<td>GLP-1 receptor signalling<\/td>\n<\/tr>\n<tr>\n<td><strong>AOD-9604<\/strong><\/td>\n<td>Growth hormone fragment research<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Unlike incretin peptides, MOTS-c is investigated primarily for <strong>cellular energy regulation and mitochondrial signalling<\/strong>, making it one of the few research peptides that directly targets mitochondrial biology.<\/p>\n<h4><strong>Observations de s\u00e9curit\u00e9 publi\u00e9es<\/strong><\/h4>\n<p>Most published data on MOTS-c come from preclinical studies, with relatively limited human interventional research available. Current investigations have generally reported acceptable tolerability in early studies, but long-term efficacy and safety remain under investigation. Because clinical evidence is still emerging, findings should be interpreted within the context of ongoing research.<\/p>\n<hr \/>\n<h4><strong>Caract\u00e9ristiques du produit<\/strong><\/h4>\n<p>Application : recherche de laboratoire et analytique<br \/>\nUtilisation restreinte : non destin\u00e9 \u00e0 la consommation humaine ; non destin\u00e9 \u00e0 un usage m\u00e9dical, v\u00e9t\u00e9rinaire ou cosm\u00e9tique<br \/>\nProduit dans des installations conformes aux BPF dans le cadre de protocoles de CQ stricts.<br \/>\nChaque lot est soumis \u00e0 des tests rigoureux en laboratoire apr\u00e8s production (vous trouverez le certificat d'analyse sous les photos du produit).<br \/>\nLyophilis\u00e9 (s\u00e9ch\u00e9 par cong\u00e9lation) pour une stabilit\u00e9 et une dur\u00e9e de conservation maximales.<br \/>\nScell\u00e9s dans des flacons st\u00e9riles, pr\u00eats \u00e0 \u00eatre reconstitu\u00e9s.<br \/>\nPuret\u00e9 : \u226598% (test\u00e9e par HPLC)<br \/>\nAspect : Poudre blanche\/blanc cass\u00e9 lyophilis\u00e9e<br \/>\nFormule mol\u00e9culaire : C<sub>101<\/sub>H<sub>152<\/sub>N<sub>28<\/sub>O<sub>22<\/sub>S<sub>2<\/sub><br \/>\nMolecular weight: 2174.6<br \/>\nSequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg<\/p>\n<p><strong>Stockage<\/strong>: les flacons lyophilis\u00e9s non ouverts sont mieux conserv\u00e9s <strong>r\u00e9frig\u00e9r\u00e9 \u00e0 2\u20138 \u00b0C<\/strong>, qui est la m\u00e9thode de stockage confirm\u00e9e par notre partenaire de fabrication et adapt\u00e9e jusqu'\u00e0 24 mois. La r\u00e9frig\u00e9ration est pr\u00e9f\u00e9rable car elle minimise les cycles de cong\u00e9lation-d\u00e9cong\u00e9lation inutiles lors de la manipulation de routine. Si un stockage \u00e0 plus long terme est n\u00e9cessaire, les flacons lyophilis\u00e9s non ouverts peuvent \u00e9galement \u00eatre conserv\u00e9s congel\u00e9s. Une fois reconstitu\u00e9es, toujours conserver \u00e0 2-8\u00b0C et ne pas congeler.<\/p>\n<h4><strong>Reconstitution et manipulation<\/strong><\/h4>\n<p>MOTS-c is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with <a href=\"https:\/\/life-peptide.com\/fr\/product\/bac-10-ml\/\">eau bact\u00e9riostatique<\/a> avant utilisation. Pour aider \u00e0 pr\u00e9server l'int\u00e9grit\u00e9 structurelle, ajoutez le solvant choisi lentement contre la paroi int\u00e9rieure du flacon plut\u00f4t que directement sur le pr\u00e9cipit\u00e9 peptidique, et \u00e9vitez les secousses vigoureuses. Un l\u00e9ger mouvement de rotation suffit g\u00e9n\u00e9ralement une fois que le peptide est compl\u00e8tement dissous. Les pratiques courantes de laboratoire comprennent \u00e9galement le fait de laisser les flacons r\u00e9frig\u00e9r\u00e9s atteindre la temp\u00e9rature ambiante avant la reconstitution afin de minimiser la condensation \u00e0 l'int\u00e9rieur du flacon.<\/p>\n<p>Pour d'autres choix de solvant, une planification de la concentration et des conseils de stockage, consultez le guide complet <a href=\"https:\/\/life-peptide.com\/fr\/reconstitution-of-peptides\/\">Guide de reconstitution des peptides<\/a> et <a href=\"https:\/\/life-peptide.com\/fr\/calculator\/\">Calculateur de reconstitution<\/a>.<\/p>\n<hr \/>\n<h4><strong>R\u00e9f\u00e9rences de recherche s\u00e9lectionn\u00e9es<\/strong><\/h4>\n<ul>\n<li>Lee C, et al. <em>The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance, Cell Metabolism<\/em>, 2015<\/li>\n<\/ul>\n<p>The landmark paper describing the discovery of MOTS-c and its role in metabolic regulation.<\/p>\n<ul>\n<li>Zhou H, et al. <em>Mitochondria-derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging, Journal of Translational Medicine<\/em>, 2023<\/li>\n<\/ul>\n<p>A comprehensive review summarising current evidence on MOTS-c biology, metabolism, stress adaptation and aging.<\/p>\n<ul>\n<li>Atakan MM, Bishop DJ. <em>Small Peptides: Could They Have a Big Role in Metabolism and the Response to Exercise?, Journal of Physiology,<\/em> 2024<\/li>\n<\/ul>\n<p>A modern review examining mitochondrial-derived peptides, including MOTS-c, with a focus on exercise physiology and metabolic adaptation.<\/p>\n<ul>\n<li>Bobylev AG, et al. <em>Mitochondrial Peptide MOTS-c: Regulation of Metabolism and Prospects for Clinical and Sports Medicine Applications, Human Physiology<\/em>, 2025<\/li>\n<\/ul>\n<p>A review discussing emerging evidence for MOTS-c in metabolism, exercise physiology and healthy aging.<\/p>\n<hr \/>\n<h4><strong>Questions fr\u00e9quemment pos\u00e9es<\/strong><\/h4>\n<p><strong>What is MOTS-c?<\/strong><\/p>\n<p>MOTS-c is a naturally occurring mitochondrial-derived peptide encoded by mitochondrial DNA. It is widely investigated for its role in cellular energy metabolism, exercise adaptation and healthy aging.<\/p>\n<p><strong>Why is MOTS-c associated with exercise research?<\/strong><\/p>\n<p>Published studies have shown that endogenous MOTS-c levels increase in response to exercise. Researchers are investigating whether it contributes to metabolic adaptations associated with physical activity through pathways such as AMPK signalling.<\/p>\n<p><strong>What makes MOTS-c different from GLP-1 peptides?<\/strong><\/p>\n<p>Unlike GLP-1 receptor agonists, which primarily investigate incretin signalling, MOTS-c focuses on mitochondrial communication, cellular energy regulation and metabolic adaptation. These represent distinct areas of metabolic research.<\/p>\n<p><strong>What research areas commonly investigate MOTS-c?<\/strong><\/p>\n<p>Current research includes cellular metabolism, mitochondrial biology, insulin sensitivity, exercise physiology, AMPK signalling, skeletal muscle adaptation and healthy aging.<\/p>\n<p><strong>How does MOTS-c differ from SS-31?<\/strong><\/p>\n<p>Both are mitochondrial peptides, but they investigate different aspects of mitochondrial biology. MOTS-c is primarily associated with metabolic signalling and exercise adaptation, whereas SS-31 is investigated for mitochondrial membrane integrity and bioenergetics.<\/p>\n<p><strong>Is MOTS-c an exercise replacement?<\/strong><\/p>\n<p>No. Although MOTS-c has been described as an exercise-mimetic peptide because it activates some exercise-related metabolic pathways, current research does not support the conclusion that it reproduces the full physiological effects of physical exercise.<\/p>\n<p><strong>Can I buy MOTS-c in Europe?<\/strong><\/p>\n<p>Yes. We ship MOTS-c to most European countries using reliable courier services. Available shipping methods and delivery times are shown during checkout based on your destination.<\/p>\n<p><strong>Ce produit est-il destin\u00e9 \u00e0 un usage humain ?<\/strong><\/p>\n<p>No. MOTS-c supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the scientific literature relating to the MOTS-c molecule rather than the intended use of this product.<\/p>\n<hr \/>\n<h4><strong>Contexte de recherche connexe<\/strong><\/h4>\n<p>MOTS-c is frequently discussed alongside other research peptides investigating mitochondrial function, metabolism and healthy aging, although each targets different aspects of cellular physiology.<\/p>\n<p><a href=\"https:\/\/life-peptide.com\/fr\/product\/ss-31\/\">SS-31<\/a> (\u00c9lamipretide) \u2013 \u00e9tudi\u00e9 pour la r\u00e9paration mitochondriale et la production d'\u00e9nergie cellulaire.<br \/>\nEpitalon \u2013 studied for telomere biology and healthy aging research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/fr\/product\/cjc-1295-with-dac\/\">CJC-1295 avec DAC<\/a> \u2013 \u00e9tudi\u00e9 pour une signalisation prolong\u00e9e de la GH et de l'IGF-1.<br \/>\n<a href=\"https:\/\/life-peptide.com\/fr\/product\/cjc-1295-no-dac\/\">CJC-1295 sans DAC<\/a> \u2013 studied for physiological growth hormone release.<br \/>\n<a href=\"https:\/\/life-peptide.com\/fr\/product\/ghk-cu-50-mg\/\">GHK-Cu<\/a> \u2013 investigated for tissue regeneration and extracellular matrix remodelling.<\/p>\n<hr \/>\n<p><strong>REMARQUE : <\/strong>Ces informations sont fournies \u00e0 titre purement informatif et ne constituent en aucun cas un avis m\u00e9dical.<\/p>\n<p><strong>Avis de non-responsabilit\u00e9 :<\/strong><br \/>\nCe produit est vendu \u00e0 des fins de recherche uniquement. Il n'est pas destin\u00e9 \u00e0 diagnostiquer, traiter, gu\u00e9rir ou pr\u00e9venir une maladie. L'acheteur assume la pleine responsabilit\u00e9 de sa manipulation et de son utilisation appropri\u00e9es.<\/p>","protected":false},"excerpt":{"rendered":"<p>MOTS-c 10 mg is a research-grade mitochondrial-derived peptide supplied in lyophilised form for laboratory use. It is one of the most extensively investigated peptides for cellular energy metabolism, exercise adaptation and healthy aging, making it a leading research tool in mitochondrial physiology and metabolic science.<\/p>\n<p>||<\/p>\n<p>Puret\u00e9 \u226599% | Achetez en Europe avec des frais de livraison \u00e0 partir de 5 \u20ac | Possibilit\u00e9 de b\u00e9n\u00e9ficier de la livraison gratuite | Paiements par carte accept\u00e9s<\/p>","protected":false},"featured_media":1239,"template":"","meta":[],"product_brand":[],"product_cat":[131],"product_tag":[328,329,324,325,153,323,327,322,138,145,326],"class_list":["post-252","product","type-product","status-publish","has-post-thumbnail","product_cat-cellular-mitochondrial-research","product_tag-ampk-signaling","product_tag-cellular-energy","product_tag-exercise-peptide","product_tag-healthy-aging","product_tag-metabolic-research","product_tag-mitochondrial-peptide","product_tag-mitochondrial-derived-peptide","product_tag-mots-c-peptide","product_tag-retatrutide","product_tag-semaglutide","product_tag-ss-31","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/product\/252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/media\/1239"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/media?parent=252"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/product_brand?post=252"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/product_cat?post=252"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/fr\/wp-json\/wp\/v2\/product_tag?post=252"}],"curies":[{"name":"Bien jou\u00e9","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}