{"id":1274,"date":"2026-07-20T16:00:20","date_gmt":"2026-07-20T13:00:20","guid":{"rendered":"https:\/\/life-peptide.com\/?post_type=product&#038;p=1274"},"modified":"2026-07-21T15:59:06","modified_gmt":"2026-07-21T12:59:06","slug":"cjc-1295-with-dac","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/it\/product\/cjc-1295-with-dac\/","title":{"rendered":"CJC-1295 con DAC \/ 2 mg"},"content":{"rendered":"<p>CJC-1295 with DAC is a modified analogue of <strong>Growth Hormone Releasing Hormone<\/strong> (GHRH) engineered to dramatically extend its duration of action.<\/p>\n<p>Unlike <strong><a href=\"https:\/\/life-peptide.com\/it\/product\/cjc-1295-senza-dac\/\">CJC-1295 no DAC<\/a> (Modified GRF 1-29)<\/strong>, which is cleared relatively quickly, the DAC version contains a Drug Affinity Complex that binds reversibly to circulating albumin. This prolongs circulation from approximately 30 minutes to several days, allowing researchers to investigate <strong>sustained stimulation of the growth hormone axis<\/strong>.<\/p>\n<p>Because of this unique pharmacokinetic profile, CJC-1295 with DAC has become one of the most widely investigated long-acting GHRH analogues in endocrine and metabolism research.<\/p>\n<hr \/>\n<h4><strong>Why CJC-1295 with DAC is widely investigated<\/strong><\/h4>\n<p>Published research has investigated CJC-1295 with DAC in relation to:<\/p>\n<ul>\n<li><strong>sustained growth hormone signalling<\/strong><\/li>\n<li><strong>Regolazione dell'IGF-1<\/strong><\/li>\n<li><strong>healthy aging research<\/strong><\/li>\n<li><strong>body composition<\/strong><\/li>\n<li><strong>muscle physiology<\/strong><\/li>\n<li><strong>recovery biology<\/strong><\/li>\n<li><strong>protein metabolism<\/strong><\/li>\n<li><strong>fisiologia endocrina<\/strong><\/li>\n<li><strong>Segnalazione del recettore del GHRH<\/strong><\/li>\n<\/ul>\n<p>Unlike short-acting GHRH analogues, the DAC version is primarily investigated for maintaining <strong>prolonged GH and IGF-1 elevation<\/strong> rather than generating brief physiological pulses.<\/p>\n<h4><strong>How CJC-1295 with DAC works<\/strong><\/h4>\n<p><strong>Drug Affinity Complex (DAC)<\/strong><\/p>\n<p>The defining feature of this peptide is the Drug Affinity Complex, which enables reversible binding to serum albumin.\u00a0Albumin binding protects the peptide from rapid degradation and renal clearance, extending its biological activity for several days.<\/p>\n<p><strong>Growth hormone release<\/strong><\/p>\n<p>CJC-1295 with DAC activates GHRH receptors in the pituitary gland, stimulating endogenous growth hormone secretion.\u00a0Because the peptide remains in circulation much longer than the No DAC version, published studies have reported sustained increases in circulating GH and IGF-1.<\/p>\n<p><strong>IGF-1 research<\/strong><\/p>\n<p>One of the principal reasons for developing CJC-1295 with DAC was to achieve prolonged elevation of IGF-1, allowing researchers to investigate the effects of sustained GHRH signalling on metabolism and tissue physiology.<\/p>\n<p><strong>Fisiologia endocrina<\/strong><\/p>\n<p>Researchers have also investigated how prolonged GHRH receptor activation differs from physiological pulsatile secretion, making CJC-1295 with DAC an important tool in comparative endocrine research.<\/p>\n<hr \/>\n<h4><strong>Why CJC-1295 with DAC differs from CJC-1295 No DAC<\/strong><\/h4>\n<p>Although they share the same peptide backbone, CJC-1295 with DAC and CJC-1295 No DAC are pharmacologically distinct compounds.<\/p>\n<p><strong>CJC-1295 con DAC<\/strong><\/p>\n<ul>\n<li>Long-acting (approximately 5\u20138-day half-life)<\/li>\n<li>Sustained GH and IGF-1 elevation<\/li>\n<li>Albumin binding through the Drug Affinity Complex<\/li>\n<li>Designed for prolonged endocrine stimulation<\/li>\n<\/ul>\n<p><strong><a href=\"https:\/\/life-peptide.com\/it\/product\/cjc-1295-senza-dac\/\">CJC-1295 no DAC<\/a> (Modified GRF 1-29)<\/strong><\/p>\n<ul>\n<li>Short-acting (approximately 30-minute half-life)<\/li>\n<li>Impulsi fisiologici di GH<\/li>\n<li>Rapid clearance<\/li>\n<li>Designed to mimic natural GHRH secretion<\/li>\n<\/ul>\n<p>For this reason, the two peptides are not interchangeable and are often selected for different research objectives.<\/p>\n<h4><strong>Ricerca umana e preclinica<\/strong><\/h4>\n<p>CJC-1295 with DAC has progressed into early human clinical investigation.<\/p>\n<p>Published studies demonstrated prolonged increases in circulating growth hormone and IGF-1 following administration, confirming that the Drug Affinity Complex successfully extends biological activity compared with conventional GHRH analogues. Research continues to explore applications in endocrinology, metabolism and healthy aging.<\/p>\n<h4><strong>Osservazioni di sicurezza pubblicate<\/strong><\/h4>\n<p>Early clinical studies generally reported <strong>favourable tolerability<\/strong>. The most frequently reported adverse events included mild injection-site reactions and transient flushing. Researchers also noted prolonged elevations of GH and IGF-1 consistent with the peptide&#8217;s extended half-life, which distinguishes it from the shorter-acting No DAC formulation.<\/p>\n<hr \/>\n<h3><strong>Caratteristiche del prodotto<\/strong><\/h3>\n<p>Applicazione: ricerca di laboratorio e analitica<br \/>\nUso limitato: non per il consumo umano; non per uso medico, veterinario o cosmetico<br \/>\nProdotto in stabilimenti conformi alle GMP secondo rigidi protocolli di controllo qualit\u00e0.<br \/>\nOgni lotto viene accuratamente testato in laboratorio dopo la produzione (puoi trovare il Certificato di Analisi sotto le immagini del prodotto).<br \/>\nLiofilizzato (liofilizzato) per la massima stabilit\u00e0 e una lunga durata di conservazione.<br \/>\nSigillato in fiale sterili, pronto per la ricostituzione.<br \/>\nPurity: \u2265 99.64% , HPLC tested<br \/>\nAspetto: polvere liofilizzata bianca<br \/>\nFormula molecolare: C<sub>165<\/sub>H<sub>269<\/sub>N<sub>47<\/sub>O<sub>46<\/sub><br \/>\nMolecular weight: 3647.65<\/p>\n<p><strong>Archiviazione<\/strong>flaconcini liofilizzati non aperti sono meglio conservati <strong>refrigerato a 2\u20138\u00b0C<\/strong>, che \u00e8 il metodo di conservazione confermato dal nostro partner di produzione e adatto fino a 24 mesi. Si preferisce la refrigerazione perch\u00e9 minimizza inutili cicli di congelamento-scongelamento durante la manipolazione di routine. Se \u00e8 necessaria una conservazione a termine sostanzialmente pi\u00f9 lungo, i flaconcini liofilizzati non aperti possono anche essere conservati congelati. Una volta ricostituita, conservare sempre a 2-8\u00b0C e non congelare.<\/p>\n<h4><strong>Ricostituzione e manipolazione<\/strong><\/h4>\n<p>Il CJC-1295 viene fornito in una fiala liofilizzata e deve essere manipolato utilizzando procedure standard di ricostituzione dei peptidi appropriate per l'ambiente di ricerca. Deve essere ricostituito con <a href=\"https:\/\/life-peptide.com\/it\/product\/bac-10-ml\/\">acqua batteriostatica<\/a> prima dell'uso. Per aiutare a preservare l'integrit\u00e0 strutturale, aggiungere il solvente scelto lentamente contro la parete interna del flaconcino piuttosto che direttamente sulla polvere del peptide, ed evitare agitazioni vigorose. Il delicato movimento rotatorio \u00e8 generalmente sufficiente una volta che il peptide si \u00e8 completamente sciolto. La pratica standard di laboratorio include anche il far raggiungere ai flaconcini refrigerati la temperatura ambiente prima della ricostituzione per minimizzare la condensa all'interno del flaconcino.<\/p>\n<p>Per altre indicazioni sulla scelta del solvente, sulla pianificazione della concentrazione e sullo stoccaggio, consultare il pieno <a href=\"https:\/\/life-peptide.com\/it\/reconstitution-of-peptides\/\">Guida alla Ricostituzione dei Peptidi<\/a> e <a href=\"https:\/\/life-peptide.com\/it\/calculator\/\">Calcolatore di Ricostituzione<\/a>.<\/p>\n<hr \/>\n<h4><strong>Riferimenti di ricerca selezionati<\/strong><\/h4>\n<ul>\n<li>Teichman SL, et al. <em>Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, Journal of Clinical Endocrinology &amp; Metabolism<\/em>, 2006<\/li>\n<\/ul>\n<p>The landmark first-in-human study demonstrating prolonged increases in GH and IGF-1 following administration of CJC-1295 with DAC.<\/p>\n<ul>\n<li>Drug Affinity Complex pharmacology<\/li>\n<\/ul>\n<p>Research describing albumin binding, extended half-life and pharmacokinetics of CJC-1295 with DAC compared with short-acting Modified GRF (1-29).<\/p>\n<ul>\n<li>Modern comparative reviews<\/li>\n<\/ul>\n<p>Recent reviews summarising the pharmacological differences between CJC-1295 with DAC and CJC-1295 No DAC, with emphasis on sustained versus pulsatile GH signalling.<\/p>\n<hr \/>\n<h4><strong>Domande Frequenti<\/strong><\/h4>\n<p><strong>What is CJC-1295 with DAC?<\/strong><\/p>\n<p>CJC-1295 with DAC is a long-acting analogue of growth hormone-releasing hormone (GHRH). The attached Drug Affinity Complex extends its circulation time, making it widely investigated for sustained GH and IGF-1 signalling.<\/p>\n<p><strong>What does DAC mean?<\/strong><\/p>\n<p>DAC stands for Drug Affinity Complex, a chemical modification that enables reversible albumin binding and dramatically prolongs the peptide&#8217;s half-life.<\/p>\n<p><strong>How is CJC-1295 with DAC different from No DAC?<\/strong><\/p>\n<p>The DAC version provides prolonged GH and IGF-1 elevation, whereas CJC-1295 No DAC (Modified GRF 1-29) produces short-lived, physiological GH pulses. They are different research tools rather than different strengths of the same peptide.<\/p>\n<p><strong>Why is CJC-1295 with DAC investigated for IGF-1?<\/strong><\/p>\n<p>Its extended duration of action allows researchers to study sustained stimulation of the GH\/IGF-1 axis over several days rather than transient hormone pulses.<\/p>\n<p><strong>Can CJC-1295 with DAC be combined with other GH peptides?<\/strong><\/p>\n<p>In published research, CJC-1295 with DAC has often been discussed alongside peptides that stimulate growth hormone through complementary mechanisms, including Ipamorelin. The combination is investigated because the peptides act through different receptor systems, although each retains a distinct pharmacological profile.<\/p>\n<p><strong>Questo prodotto \u00e8 destinato all'uso umano?<\/strong><\/p>\n<p>No. CJC-1295 with DAC supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.<\/p>\n<hr \/>\n<h4><strong>Contesto di ricerca correlato<\/strong><\/h4>\n<p>CJC-1295 with DAC is frequently discussed alongside other research peptides investigating growth hormone signalling, recovery and healthy aging.<\/p>\n<p><a href=\"https:\/\/life-peptide.com\/it\/product\/cjc-1295-senza-dac\/\"><strong>CJC-1295 no DAC<\/strong><\/a> (Modified GRF 1-29) \u2013 investigated for physiological pulsatile growth hormone release and short-duration GHRH signalling.<br \/>\n<a href=\"https:\/\/life-peptide.com\/it\/product\/ipamorelin-5-mg\/\"><strong>Ipamorelin<\/strong> <\/a>\u2013 studied as a selective ghrelin receptor agonist that stimulates endogenous growth hormone release through a complementary pathway.<br \/>\n<a href=\"https:\/\/life-peptide.com\/it\/product\/tesamorelin-10-mg\/\"><strong>Tesamorelin<\/strong> <\/a>\u2013 investigated as a clinically validated GHRH analogue with established endocrine research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/it\/product\/mots-c-10-mg\/\"><strong>MOTS-c<\/strong> <\/a>\u2013 focuses on mitochondrial metabolism, exercise adaptation and healthy aging rather than direct GH signalling.<br \/>\n<a href=\"https:\/\/life-peptide.com\/it\/product\/epitalon-10-mg\/\"><strong>Epitalon<\/strong> <\/a>\u2013 investigated for telomere biology, circadian regulation and longevity research.<br \/>\n<a href=\"https:\/\/life-peptide.com\/it\/product\/ss-31\/\"><strong>SS-31<\/strong><\/a> \u2013 investigated for mitochondrial function and cellular bioenergetics.<\/p>\n<p>Although these peptides are often grouped within performance and healthy aging research, CJC-1295 with DAC is distinguished by its sustained activation of the growth hormone axis, whereas the others target different biological pathways.<\/p>\n<p><strong>NOTA<\/strong>: Questo \u00e8 solo a scopo didattico e non costituisce parere medico.<\/p>\n<p><strong>Disclaimer<\/strong><br \/>\nQuesto prodotto \u00e8 venduto esclusivamente a scopo di ricerca. Non \u00e8 destinato a diagnosticare, trattare, curare o prevenire alcuna malattia. L'acquirente si assume la piena responsabilit\u00e0 per la corretta manipolazione e utilizzo.<\/p>","protected":false},"excerpt":{"rendered":"<p>CJC-1295 with DAC \/ 2 mg is a research-grade long-acting GHRH analogue supplied in lyophilised form for laboratory use. By incorporating a Drug Affinity Complex (DAC), it remains active for several days, making it one of the best-known peptides for sustained growth hormone and IGF-1 research.<\/p>\n<p>||<\/p>\n<p>Purity \u226599% | EU Shipping from \u20ac5 | Free shipping upgrades available | Card payments accepted<\/p>","protected":false},"featured_media":1273,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[21],"product_tag":[354,358,356,290,357,320,355,282],"class_list":["post-1274","product","type-product","status-publish","has-post-thumbnail","product_cat-growth-hormone-secretagogues","product_tag-cjc-1295-with-dac","product_tag-endocrine-research","product_tag-ghrh-analogue","product_tag-growth-hormone-peptide","product_tag-healthy-aging-peptide","product_tag-igf-1-research","product_tag-long-acting-ghrh","product_tag-recovery-peptide","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product\/1274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/comments?post=1274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/media\/1273"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/media?parent=1274"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product_brand?post=1274"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product_cat?post=1274"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product_tag?post=1274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}