{"id":910,"date":"2026-04-27T16:55:29","date_gmt":"2026-04-27T13:55:29","guid":{"rendered":"https:\/\/life-peptide.com\/?post_type=product&#038;p=910"},"modified":"2026-07-21T11:11:23","modified_gmt":"2026-07-21T08:11:23","slug":"melanotan-2-10-mg","status":"publish","type":"product","link":"https:\/\/life-peptide.com\/it\/product\/melanotan-2-10-mg\/","title":{"rendered":"Melanotan 2 (MT2) \/ 10 mg"},"content":{"rendered":"<p>Melanotan 2 (also known as Melanotan II or MT2) is one of the best-known research peptides for <strong>tanning and pigmentation studies<\/strong>. It is a synthetic <strong>analogue of \u03b1-melanocyte-stimulating hormone (\u03b1-MSH)<\/strong>, developed to investigate how melanocortin signalling regulates melanin production and the skin&#8217;s physiological response to ultraviolet (UV) exposure.<\/p>\n<p>Beyond pigmentation research, Melanotan 2 has played an important role in advancing our understanding of the melanocortin system. During early clinical investigations, researchers observed effects beyond skin pigmentation, leading to the later development of <a href=\"https:\/\/life-peptide.com\/it\/product\/pt-141-10-mg\/\"><strong>PT-141 (Bremelanotide)<\/strong><\/a>, a more selective melanocortin peptide designed specifically for sexual function research.<\/p>\n<p>Today, Melanotan 2 remains one of the most extensively investigated peptides for pigmentation biology, melanocortin receptor signalling and neuroendocrine physiology.<\/p>\n<hr \/>\n<h4><strong>Why Melanotan 2 is widely investigated<\/strong><\/h4>\n<p>Published research has investigated Melanotan 2 in relation to:<\/p>\n<ul>\n<li>tanning research<\/li>\n<li>skin pigmentation<\/li>\n<li>melanin production<\/li>\n<li>melanogenesis<\/li>\n<li>UV-independent pigmentation<\/li>\n<li>melanocyte biology<\/li>\n<li>melanocortin receptor signalling<\/li>\n<li>appetite regulation<\/li>\n<li>neuroendocrine physiology<\/li>\n<\/ul>\n<p>Its broad receptor activity has made Melanotan 2 one of the foundational research peptides for understanding the melanocortin system.<\/p>\n<h4><strong>How Melanotan 2 promotes pigmentation<\/strong><\/h4>\n<p>Published research demonstrates that Melanotan 2 primarily <strong>activates the MC1 melanocortin receptor<\/strong>, which regulates melanin production within melanocytes.<\/p>\n<p>Research has explored its relationship with:<\/p>\n<p><strong>Melanin production<\/strong><\/p>\n<p>Activation of melanocytes and increased melanin synthesis, making Melanotan 2 one of the best-known peptides in pigmentation research.<\/p>\n<p><strong>UV response<\/strong><\/p>\n<p>Investigation of the relationship between melanocortin signalling, melanin production and the skin&#8217;s physiological response to ultraviolet exposure.<\/p>\n<p><strong>Pigmentation biology<\/strong><\/p>\n<p>Studies examining how melanocortin receptors regulate pigmentation across different skin types and experimental models.<\/p>\n<p>Because Melanotan 2 also activates other melanocortin receptors, researchers have investigated additional physiological pathways involving appetite regulation, energy balance and central nervous system signalling.<\/p>\n<h4><strong>Why Melanotan 2 became important beyond tanning research<\/strong><\/h4>\n<p>Although Melanotan 2 was originally developed for pigmentation research, investigators later discovered that melanocortin receptor activation also influenced central nervous system pathways involved in sexual behaviour.<\/p>\n<p>These findings ultimately led to the development of <a href=\"https:\/\/life-peptide.com\/it\/product\/pt-141-10-mg\/\"><strong>PT-141 (Bremelanotide)<\/strong><\/a>, a more selective melanocortin peptide that focuses on sexual desire and arousal research rather than pigmentation.<\/p>\n<p>This makes Melanotan 2 one of the most influential peptides in the history of melanocortin research.<\/p>\n<hr \/>\n<h4><strong>Ricerca umana e preclinica<\/strong><\/h4>\n<p>Melanotan 2 has been investigated extensively in both laboratory and human studies.<\/p>\n<p>Published research includes:<\/p>\n<ul>\n<li>tanning physiology<\/li>\n<li>pigmentation biology<\/li>\n<li>melanogenesis<\/li>\n<li>UV response<\/li>\n<li>melanocortin receptor pharmacology<\/li>\n<li>appetite regulation<\/li>\n<li>neuroendocrine signalling<\/li>\n<\/ul>\n<p>Although newer melanocortin analogues have since been developed for more specific applications, Melanotan 2 remains one of the principal research compounds for studying the melanocortin receptor family.<\/p>\n<h4><strong>How Melanotan 2 differs from related peptides<\/strong><\/h4>\n<table style=\"height: 142px;\" width=\"730\">\n<thead>\n<tr>\n<th>Research objective<\/th>\n<th>Recommended peptide<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Tanning &amp; pigmentation research<\/strong><\/td>\n<td><strong>Melanotan 2<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Sexual desire &amp; arousal research<\/strong><\/td>\n<td><a href=\"https:\/\/life-peptide.com\/it\/product\/pt-141-10-mg\/\"><strong>PT-141 (Bremelanotide)<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Reproductive hormone regulation<\/strong><\/td>\n<td><a href=\"https:\/\/life-peptide.com\/it\/product\/kisspeptin-10-5-mg\/\"><strong>Kisspeptin-10<\/strong><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Social bonding &amp; neuroendocrine behaviour<\/strong><\/td>\n<td><a href=\"https:\/\/life-peptide.com\/it\/product\/oxytocin-5-mg\/\"><strong>Oxytocin<\/strong><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Although Melanotan 2 and PT-141 share a common developmental history, they are now investigated for different research objectives. Melanotan 2 primarily focuses on pigmentation and melanocortin biology, whereas PT-141 investigates central pathways involved in sexual desire and arousal.<\/p>\n<h4><strong>Osservazioni di sicurezza pubblicate<\/strong><\/h4>\n<p>Published human studies have most commonly reported <strong>nausea, facial flushing, yawning and transient increases in skin pigmentation<\/strong>. Researchers have also observed increased pigmentation of freckles and existing moles, which has become an area of continued investigation. Current knowledge is based primarily on controlled clinical studies and experimental research, and long-term safety remains an active topic within the scientific literature.<\/p>\n<hr \/>\n<h4><strong>Caratteristiche del prodotto<\/strong><\/h4>\n<p>Applicazione: ricerca di laboratorio e analitica<br \/>\nUso limitato: non per il consumo umano; non per uso medico, veterinario o cosmetico<br \/>\nProdotto in stabilimenti conformi alle GMP secondo rigidi protocolli di controllo qualit\u00e0.<br \/>\nOgni lotto viene accuratamente testato in laboratorio dopo la produzione (puoi trovare il Certificato di Analisi sotto le immagini del prodotto).<br \/>\nLiofilizzato (liofilizzato) per la massima stabilit\u00e0 e una lunga durata di conservazione.<br \/>\nSigillato in fiale sterili, pronto per la ricostituzione.<br \/>\nPurity: \u2265 99% (HPLC)<br \/>\nAspetto: polvere liofilizzata bianca<br \/>\nFormula molecolare: C<sub>50<\/sub>H<sub>69<\/sub>N<sub>15<\/sub>O<sub>9<\/sub><br \/>\nMolecular weight: 1024.2<br \/>\nCAS No: 121062-08-6<\/p>\n<p><strong>Archiviazione<\/strong>flaconcini liofilizzati non aperti sono meglio conservati <strong>refrigerato a 2\u20138\u00b0C<\/strong>, che \u00e8 il metodo di conservazione confermato dal nostro partner di produzione e adatto fino a 24 mesi. Si preferisce la refrigerazione perch\u00e9 minimizza inutili cicli di congelamento-scongelamento durante la manipolazione di routine. Se \u00e8 necessaria una conservazione a termine sostanzialmente pi\u00f9 lungo, i flaconcini liofilizzati non aperti possono anche essere conservati congelati. Una volta ricostituita, conservare sempre a 2-8\u00b0C e non congelare.<\/p>\n<h4><strong>Ricostituzione e manipolazione<\/strong><\/h4>\n<p>Melanotan 2 is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with <a href=\"https:\/\/life-peptide.com\/it\/product\/bac-10-ml\/\">acqua batteriostatica<\/a> prima dell'uso. Per aiutare a preservare l'integrit\u00e0 strutturale, aggiungere il solvente scelto lentamente contro la parete interna del flaconcino piuttosto che direttamente sulla polvere del peptide, ed evitare agitazioni vigorose. Il delicato movimento rotatorio \u00e8 generalmente sufficiente una volta che il peptide si \u00e8 completamente sciolto. La pratica standard di laboratorio include anche il far raggiungere ai flaconcini refrigerati la temperatura ambiente prima della ricostituzione per minimizzare la condensa all'interno del flaconcino.<\/p>\n<p>Per altre indicazioni sulla scelta del solvente, sulla pianificazione della concentrazione e sullo stoccaggio, consultare il pieno <a href=\"https:\/\/life-peptide.com\/it\/reconstitution-of-peptides\/\">Guida alla Ricostituzione dei Peptidi<\/a> e <a href=\"https:\/\/life-peptide.com\/it\/calculator\/\">Calcolatore di Ricostituzione<\/a>.<\/p>\n<hr \/>\n<h4><strong>Riferimenti di ricerca selezionati<\/strong><\/h4>\n<ul>\n<li>Hadley ME. <em>Melanocortin Peptide Therapeutics: Historical Milestones, Clinical Studies and Commercialization, Peptides<\/em>, 2006<\/li>\n<\/ul>\n<p>A comprehensive review describing the development of Melanotan peptides, pigmentation research and the subsequent evolution of PT-141 from Melanotan 2.<\/p>\n<ul>\n<li>Dorr RT, et al. <em>Evaluation of Melanotan-II, a Superpotent Cyclic Melanotropic Peptide in a Pilot Phase I Clinical Study, Life Sciences<\/em>, 1996<\/li>\n<\/ul>\n<p>The first human clinical study evaluating Melanotan 2 and its effects on pigmentation.<\/p>\n<ul>\n<li>Habbema L, Halk AB, Neumann M, Bergman W. <em>Risks of Unregulated Use of Alpha-Melanocyte-Stimulating Hormone Analogues: A Review, International Journal of Dermatology<\/em>, 2017<\/li>\n<\/ul>\n<p>A review summarising the published evidence on Melanotan analogues, pigmentation effects and reported safety considerations.<\/p>\n<ul>\n<li>Wessells H, et al. <em>Melanocortin Receptor Agonists and Human Sexual Function, International Journal of Impotence Research,<\/em> 2000<\/li>\n<\/ul>\n<p>One of the early human studies showing central nervous system effects beyond pigmentation, contributing to the later development of PT-141.<\/p>\n<hr \/>\n<h4><strong>Domande Frequenti<\/strong><\/h4>\n<p><strong>What is Melanotan 2?<\/strong><\/p>\n<p>Melanotan 2 is a synthetic analogue of \u03b1-melanocyte-stimulating hormone (\u03b1-MSH). It is one of the world&#8217;s most extensively investigated research peptides for tanning, pigmentation and melanocortin receptor biology.<\/p>\n<p><strong>How does Melanotan 2 promote pigmentation?<\/strong><\/p>\n<p>Melanotan 2 primarily activates the MC1 melanocortin receptor, which regulates melanin production within melanocytes. This has made it one of the leading research peptides for pigmentation and tanning studies.<\/p>\n<p><strong>How does Melanotan 2 differ from PT-141?<\/strong><\/p>\n<p>Although PT-141 was developed from Melanotan 2, the two peptides are investigated for different purposes. Melanotan 2 primarily focuses on pigmentation and melanocortin biology, while PT-141 is a more selective melanocortin peptide investigated mainly for sexual desire and arousal research.<\/p>\n<p><strong>Why is Melanotan 2 associated with appetite and sexual function research?<\/strong><\/p>\n<p>Melanotan 2 activates several melanocortin receptor subtypes in addition to MC1R, including receptors involved in appetite regulation and central nervous system signalling. Early studies unexpectedly observed effects on sexual function, which contributed to the later development of PT-141.<\/p>\n<p><strong>What research areas commonly investigate Melanotan 2?<\/strong><\/p>\n<p>Published research includes tanning physiology, skin pigmentation, melanogenesis, UV response, melanocortin receptor signalling, appetite regulation and neuroendocrine physiology.<\/p>\n<p><strong>How does Melanotan 2 differ from Melanotan 1 (Afamelanotide)?<\/strong><\/p>\n<p>Both peptides are derived from \u03b1-MSH, but Melanotan 2 activates multiple melanocortin receptor subtypes, whereas Afamelanotide is considerably more selective for MC1R. This broader receptor activity has made Melanotan 2 useful across a wider range of melanocortin research topics.<\/p>\n<p><strong>Questo prodotto \u00e8 destinato all'uso umano?<\/strong><\/p>\n<p>No. Melanotan 2 supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the current scientific literature relating to the Melanotan 2 molecule rather than the intended use of this product.<\/p>\n<hr \/>\n<h4><strong>Contesto di ricerca correlato<\/strong><\/h4>\n<p>Melanotan 2 belongs to the broader <a href=\"\/it\/categoria\/sexual-function-and-melanocortin-peptides\/\">Melanocortin and neuroendocrine peptide research category<\/a>, focusing on pigmentation pathways and central melanocortin signaling mechanisms.<br \/>\nResearchers exploring related melanocortin pathway models may also examine:<br \/>\n\u2022 <a href=\"https:\/\/life-peptide.com\/it\/product\/pt-141-10-mg\/\">PT-141 (Bremelanotide)<\/a> \u2014 selective melanocortin receptor signaling research<br \/>\n\u2022 <a href=\"\/it\/categoria\/cognitive-research-peptides\/\">Cognitive &amp; neuroresearch peptides<\/a> \u2014 CNS peptide signaling models<\/p>\n<p><strong>NOTA<\/strong>: Questo \u00e8 solo a scopo didattico e non costituisce parere medico.<\/p>\n<p><strong>Disclaimer<\/strong><br \/>\nQuesto prodotto \u00e8 venduto esclusivamente a scopo di ricerca. Non \u00e8 destinato a diagnosticare, trattare, curare o prevenire alcuna malattia. L'acquirente si assume la piena responsabilit\u00e0 per la corretta manipolazione e utilizzo.<\/p>","protected":false},"excerpt":{"rendered":"<p>Melanotan 2 is a synthetic melanocortin peptide studied for its interaction with pigmentation pathways, melanocortin receptor signaling, and neuroendocrine research models.<\/p>\n<p>||<\/p>\n<p>Purezza \u226599% | Spedizione nell&#x27;UE a partire da 5 \u20ac | Disponibili opzioni di spedizione gratuita | Si accettano pagamenti con carta<\/p>","protected":false},"featured_media":1240,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[23],"product_tag":[224,135,219,137,227,136,220,134,226,133,225],"class_list":["post-910","product","type-product","status-publish","has-post-thumbnail","product_cat-sexual-function-and-melanocortin-peptides","product_tag-hypothalamic-signaling","product_tag-melanocortin","product_tag-melanocortin-peptide","product_tag-melanogenesis","product_tag-melanogenesis-research","product_tag-mt2","product_tag-neuroendocrine-signaling","product_tag-pigmentation","product_tag-pigmentation-pathways","product_tag-tanning","product_tag--msh-analogue","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product\/910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/comments?post=910"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/media\/1240"}],"wp:attachment":[{"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/media?parent=910"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product_brand?post=910"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product_cat?post=910"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/life-peptide.com\/it\/wp-json\/wp\/v2\/product_tag?post=910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}