CJC-1295 with DAC is a modified analogue of Growth Hormone Releasing Hormone (GHRH) engineered to dramatically extend its duration of action.

Unlike CJC-1295 no DAC (Modified GRF 1-29), which is cleared relatively quickly, the DAC version contains a Drug Affinity Complex that binds reversibly to circulating albumin. This prolongs circulation from approximately 30 minutes to several days, allowing researchers to investigate sustained stimulation of the growth hormone axis.

Because of this unique pharmacokinetic profile, CJC-1295 with DAC has become one of the most widely investigated long-acting GHRH analogues in endocrine and metabolism research.

Why CJC-1295 with DAC is widely investigated

Published research has investigated CJC-1295 with DAC in relation to:

sustained growth hormone signalling
IGF-1 regulation
healthy aging research
body composition
muscle physiology
recovery biology
protein metabolism
endocrine physiology
GHRH receptor signalling

Unlike short-acting GHRH analogues, the DAC version is primarily investigated for maintaining prolonged GH and IGF-1 elevation rather than generating brief physiological pulses.

How CJC-1295 with DAC works

Drug Affinity Complex (DAC)

The defining feature of this peptide is the Drug Affinity Complex, which enables reversible binding to serum albumin. Albumin binding protects the peptide from rapid degradation and renal clearance, extending its biological activity for several days.

Growth hormone release

CJC-1295 with DAC activates GHRH receptors in the pituitary gland, stimulating endogenous growth hormone secretion. Because the peptide remains in circulation much longer than the No DAC version, published studies have reported sustained increases in circulating GH and IGF-1.

IGF-1 research

One of the principal reasons for developing CJC-1295 with DAC was to achieve prolonged elevation of IGF-1, allowing researchers to investigate the effects of sustained GHRH signalling on metabolism and tissue physiology.

Endocrine physiology

Researchers have also investigated how prolonged GHRH receptor activation differs from physiological pulsatile secretion, making CJC-1295 with DAC an important tool in comparative endocrine research.

Why CJC-1295 with DAC differs from CJC-1295 No DAC

Although they share the same peptide backbone, CJC-1295 with DAC and CJC-1295 No DAC are pharmacologically distinct compounds.

CJC-1295 with DAC

Long-acting (approximately 5–8-day half-life)
Sustained GH and IGF-1 elevation
Albumin binding through the Drug Affinity Complex
Designed for prolonged endocrine stimulation

CJC-1295 no DAC (Modified GRF 1-29)

Short-acting (approximately 30-minute half-life)
Physiological GH pulses
Rapid clearance
Designed to mimic natural GHRH secretion

For this reason, the two peptides are not interchangeable and are often selected for different research objectives.

Human and preclinical research

CJC-1295 with DAC has progressed into early human clinical investigation.

Published studies demonstrated prolonged increases in circulating growth hormone and IGF-1 following administration, confirming that the Drug Affinity Complex successfully extends biological activity compared with conventional GHRH analogues. Research continues to explore applications in endocrinology, metabolism and healthy aging.

Published safety observations

Early clinical studies generally reported favourable tolerability. The most frequently reported adverse events included mild injection-site reactions and transient flushing. Researchers also noted prolonged elevations of GH and IGF-1 consistent with the peptide’s extended half-life, which distinguishes it from the shorter-acting No DAC formulation.

Product characteristics

Application: laboratory and analytical research
Use restriction: not for human consumption; not for medical, veterinary or cosmetic use
Produced in GMP-compliant facilities under strict QC protocols.
Each batch carefully lab tested after production (you can find Certificate of Analysis under product pictures).
Freeze-dried (lyophilized) for maximum stability and extended shelf life.
Sealed in sterile vials, ready for reconstitution.
Purity: ≥ 99.64% , HPLC tested
Appearance: white lyophilized powder
Molecular formula: C₁₆₅H₂₆₉N₄₇O₄₆
Molecular weight: 3647.65

Storage: unopened lyophilized vials are best stored refrigerated at 2–8°C, which is the storage method confirmed by our manufacturing partner and suitable for up to 24 months. Refrigeration is preferred because it minimizes unnecessary freeze–thaw cycles during routine handling. If substantially longer-term storage is required, unopened lyophilized vials may also be kept frozen. Once reconstituted, always store at 2–8°C and do not freeze.

Reconstitution and handling

CJC-1295 is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with bacteriostatic water before use. To help preserve structural integrity, add the chosen solvent slowly against the inside wall of the vial rather than directly onto the peptide cake, and avoid vigorous shaking. Gentle swirling is generally sufficient once the peptide has fully dissolved. Standard laboratory practice also includes allowing refrigerated vials to reach room temperature before reconstitution to minimise condensation inside the vial.

For other solvent selection, concentration planning and storage guidance, see the full Peptide Reconstitution Guide and Reconstitution Calculator.

Selected research references

Teichman SL, et al. Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, Journal of Clinical Endocrinology & Metabolism, 2006

The landmark first-in-human study demonstrating prolonged increases in GH and IGF-1 following administration of CJC-1295 with DAC.

Drug Affinity Complex pharmacology

Research describing albumin binding, extended half-life and pharmacokinetics of CJC-1295 with DAC compared with short-acting Modified GRF (1-29).

Modern comparative reviews

Recent reviews summarising the pharmacological differences between CJC-1295 with DAC and CJC-1295 No DAC, with emphasis on sustained versus pulsatile GH signalling.

Frequently Asked Questions

What is CJC-1295 with DAC?

CJC-1295 with DAC is a long-acting analogue of growth hormone-releasing hormone (GHRH). The attached Drug Affinity Complex extends its circulation time, making it widely investigated for sustained GH and IGF-1 signalling.

What does DAC mean?

DAC stands for Drug Affinity Complex, a chemical modification that enables reversible albumin binding and dramatically prolongs the peptide’s half-life.

How is CJC-1295 with DAC different from No DAC?

The DAC version provides prolonged GH and IGF-1 elevation, whereas CJC-1295 No DAC (Modified GRF 1-29) produces short-lived, physiological GH pulses. They are different research tools rather than different strengths of the same peptide.

Why is CJC-1295 with DAC investigated for IGF-1?

Its extended duration of action allows researchers to study sustained stimulation of the GH/IGF-1 axis over several days rather than transient hormone pulses.

Can CJC-1295 with DAC be combined with other GH peptides?

In published research, CJC-1295 with DAC has often been discussed alongside peptides that stimulate growth hormone through complementary mechanisms, including Ipamorelin. The combination is investigated because the peptides act through different receptor systems, although each retains a distinct pharmacological profile.

Is this product intended for human use?

No. CJC-1295 with DAC supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.

Related research context

CJC-1295 with DAC is frequently discussed alongside other research peptides investigating growth hormone signalling, recovery and healthy aging.

CJC-1295 no DAC (Modified GRF 1-29) – investigated for physiological pulsatile growth hormone release and short-duration GHRH signalling.
Ipamorelin – studied as a selective ghrelin receptor agonist that stimulates endogenous growth hormone release through a complementary pathway.
Tesamorelin – investigated as a clinically validated GHRH analogue with established endocrine research.
MOTS-c – focuses on mitochondrial metabolism, exercise adaptation and healthy aging rather than direct GH signalling.
Epitalon – investigated for telomere biology, circadian regulation and longevity research.
SS-31 – investigated for mitochondrial function and cellular bioenergetics.

Although these peptides are often grouped within performance and healthy aging research, CJC-1295 with DAC is distinguished by its sustained activation of the growth hormone axis, whereas the others target different biological pathways.

NOTE: This is for educational reference only and does not constitute medical advice.

Disclaimer
This product is sold for research purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Buyer assumes full responsibility for proper handling and use.

Long-acting GHRH

CJC-1295 with DAC / 2 mg