Semaglutide – 1st generation single incretin agonist

Product overview

Semaglutide is a long-acting investigational peptide designed as a selective GLP-1 receptor agonist. As a single-pathway incretin compound, it serves as a foundational reference in metabolic research focused on glucose regulation, appetite signaling, and energy balance.

Its extended half-life and receptor specificity make it widely used in experimental models examining sustained GLP-1 pathway activation. Compared to dual agonists such as Tirzepatide and multi-receptor compounds like Retatrutide, Semaglutide represents a more targeted approach to incretin signaling, allowing researchers to isolate GLP-1–mediated effects within complex metabolic systems.

Because of this, it is frequently used as a baseline compound in comparative studies involving single, dual, and multi-receptor agonist strategies. For a broader comparison across incretin-based compounds, see the GLP-1 metabolic research guide.

Research applications (investigational)

Semaglutide has been investigated in preclinical and experimental settings for its involvement in:

Selective GLP-1 receptor signaling pathways
Glucose metabolism and insulin-related signaling dynamics
Appetite regulation and satiety pathway modeling
Energy balance and nutrient signaling mechanisms
Gastrointestinal hormone signaling interactions
Comparative analysis of single vs multi-receptor incretin activation

These areas reflect ongoing scientific investigation into metabolic signaling systems rather than established applications.

Product characteristics

Purity: ≥99% (HPLC-tested)
Appearance: Lyophilized white/off-white powder
Molecular formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular weight: 4113.64
Sequence: His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Storage: store lyophilized powder at -20°C, protect from light and moisture. Reconstituted solution should be kept at 2–8°C and used within a short period.

Why choose our Semaglutide?

≥ 99% purity verified by HPLC.
Produced in GMP-compliant facilities under strict QC protocols.
Each batch carefully lab tested after production (you can find Certificate of Analysis under product pictures).
Freeze-dried (lyophilized) for maximum stability and extended shelf life.
Sealed in sterile vials, ready for reconstitution.
Reconstitution: Must be reconstituted with bacteriostatic water before use. GLP-1 class peptides are sometimes slow to dissolve and require very gentle reconstitution to avoid foaming or remaining slightly cloudy.

Selected research references

Wilding JPH et al. “Once-Weekly Semaglutide in Adults with Overweight or Obesity.” New England Journal of Medicine, 2021.
Rubino D et al. “Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity.” JAMA, 2022.
Davies M et al. “Semaglutide 2.4 mg once a week in adults with overweight or obesity.” Nature Reviews Endocrinology, 2021.
Lau J et al. “Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.” Journal of Medicinal Chemistry, 2015.
ClinicalTrials.gov Identifier: NCT03548935 — Semaglutide research in obesity and metabolic regulation models.

Related research context

Semaglutide belongs to the GLP-1 receptor agonist class within incretin-based metabolic research. For mechanistic comparison with dual and triple agonists, see our GLP-1 metabolic research guide.

Browse all compounds in the Metabolic research category.

For pathway comparison:

Dual agonists: Tirzepatide (GLP-1/GIP)
Triple agonists: Retatrutide (GLP-1/GIP/glucagon)

NOTE: This is for educational reference only and does not constitute medical advice.

Disclaimer:
This product is sold for research purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Buyer assumes full responsibility for proper handling and use.

Inkretingebung

Semaglutid 10 mg