SS-31 / 10 mg

Περιγραφή

SS-31, also known as Elamipretide, MTP-131 or Bendavia, is a synthetic mitochondria-targeting tetrapeptide.

Unlike most peptides, SS-31 does not primarily interact with a cell-surface receptor. Instead, it rapidly enters cells and selectively accumulates within mitochondria, where it binds cardiolipin, a phospholipid unique to the inner mitochondrial membrane.

Because cardiolipin is essential for maintaining mitochondrial architecture and efficient ATP production, SS-31 has become one of the leading investigational peptides for research into mitochondrial dysfunction, oxidative stress and cellular energy metabolism.

Why SS-31 is widely investigated

Published research has investigated SS-31 in relation to:

• mitochondrial repair
• cellular energy production
• ATP synthesis
• oxidative stress
• muscle physiology
• healthy aging
• cardiovascular research
• neurodegeneration
• mitochondrial disease

Unlike metabolic peptides that regulate cellular signalling, SS-31 directly targets the physical structure of mitochondria, making it unique among modern research peptides.

How SS-31 works

Cardiolipin stabilisation

SS-31 selectively binds cardiolipin, an essential phospholipid located within the inner mitochondrial membrane.

Cardiolipin plays a critical role in maintaining mitochondrial cristae structure and supporting the electron transport chain. Under conditions of oxidative stress, cardiolipin becomes damaged, reducing mitochondrial efficiency. Published research suggests SS-31 helps stabilise this membrane environment and preserve mitochondrial function.

Cellular energy production

By preserving mitochondrial structure, SS-31 has been investigated for improving the efficiency of oxidative phosphorylation and ATP generation. Rather than stimulating mitochondria to produce more energy, SS-31 appears to help dysfunctional mitochondria produce energy more efficiently.

Oxidative stress

Numerous preclinical studies have investigated SS-31 for reducing mitochondrial reactive oxygen species (ROS) and limiting oxidative damage associated with impaired mitochondrial function.

Tissue protection

Because mitochondria influence virtually every organ system, SS-31 has been investigated across cardiovascular, neurological, renal and skeletal muscle research, making it one of the broadest mitochondrial peptides currently available.

Why SS-31 is different from other mitochondrial peptides

Not all mitochondrial peptides investigate the same biology.

MOTS-c investigates how cells regulate energy metabolism by activating adaptive metabolic signalling pathways.

ΣΣ-31 investigates how mitochondria physically produce energy by stabilising the inner mitochondrial membrane and preserving electron transport chain function.

Rather than changing metabolic signalling, SS-31 focuses on maintaining the mitochondrial machinery itself.

This distinction has made SS-31 one of the most important investigational peptides for mitochondrial biology and healthy aging research.

Ανθρώπινη και προκλινική έρευνα

SS-31 has progressed further into clinical development than many research peptides.

Human studies have investigated SS-31 in primary mitochondrial disease, Barth syndrome, heart failure, kidney injury and ophthalmic disorders, while extensive preclinical research has explored its effects on skeletal muscle, neurodegeneration, ischemia-reperfusion injury and age-related mitochondrial dysfunction.

Although clinical results have varied by indication, SS-31 remains one of the best-characterised mitochondria-targeting peptides currently under investigation.

Δημοσιευθείσες παρατηρήσεις ασφαλείας

SS-31 has undergone multiple clinical studies across several disease areas.

Published trials have generally reported favourable tolerability, with adverse events typically mild to moderate. Clinical efficacy has varied depending on the condition under investigation, highlighting the complexity of mitochondrial diseases and the need for continued research.

Χαρακτηριστικά προϊόντος

Εφαρμογή: εργαστηριακή και αναλυτική έρευνα
Χρήση περιορισμού: όχι για ανθρώπινη κατανάλωση· όχι για ιατρική, κτηνιατρική ή καλλυντική χρήση
Παράγεται σε εγκαταστάσεις που συμμορφώνονται με τις ΟGMP υπό αυστηρά πρωτόκολλα ΠΚ.
Κάθε παρτίδα ελέγχεται προσεκτικά στο εργαστήριο μετά την παραγωγή (μπορείτε να βρείτε το Πιστοποιητικό Ανάλυσης κάτω από τις εικόνες του προϊόντος).
Κατάψυξη-αποξήρανση (λυσόφιλη) για μέγιστη σταθερότητα και παρατεταμένη διάρκεια ζωής.
Σφραγισμένα σε αποστειρωμένες φιάλες, έτοιμα για ανασύσταση.
Purity: ≥ 99.88% , HPLC tested.
Εμφάνιση: λευκή λυοφιλοποιημένη σκόνη
Μοριακός τύπος: C₃₂H₄₉N₉O₅
Molecular weight: 639.79

Αποθήκευση: τα αφυδατωμένα σε ξηρή ψύξη, σφραγισμένα φιαλίδια φυλάσσονται καλύτερα συντήρηση στους 2–8°C, η οποία είναι η μέθοδος αποθήκευσης που επιβεβαιώθηκε από τον συνεργάτη παραγωγής μας και είναι κατάλληλη για έως και 24 μήνες. Η ψύξη προτιμάται επειδή ελαχιστοποιεί τους περιττούς κύκλους ψύξης-απόψυξης κατά τον συνήθη χειρισμό. Εάν απαιτείται σημαντικά μακροχρόνια αποθήκευση, τα σφραγισμένα λυοφιλοποιημένα φιαλίδια μπορούν επίσης να διατηρηθούν κατεψυγμένα. Μόλις ανασυσταθεί, αποθηκεύετε πάντα σε 2–8°C και μην καταψύχετε.

Ανα

SS-31 is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with Βακτηριοστατικό νερό πριν τη χρήση. Για να διατηρηθεί η δομική ακεραιότητα, προσθέστε το επιλεγμένο διαλύτη αργά στο εσωτερικό τοίχωμα του φιαλιδίου αντί απευθείας στη μάζα του πεπτιδίου, και αποφύγετε το έντονο ανακίνημα. Η απαλή περιστροφή είναι γενικά επαρκής μόλις το πεπτίδιο διαλυθεί πλήρως. Η τυπική εργαστηριακή πρακτική περιλαμβάνει επίσης την αναμονή των ψυχόμενων φιαλιδίων να φτάσουν σε θερμοκρασία δωματίου πριν από την ανασύσταση για να ελαχιστοποιηθεί η συμπύκνωση στο εσωτερικό του φιαλιδίου.

Για την επιλογή άλλων διαλυτών, σχεδιασμό συγκεντρώσεων και οδηγίες αποθήκευσης, δείτε το πλήρες Οδηγός Ανασύστασης Πεπτιδίων και Υπολογιστής Απεικόνισης.

Επιλεγμένες ερευνητικές αναφορές

• Wang Y, et al. Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential, Life, 2025

A comprehensive review covering SS-31’s mechanism, cardiolipin binding, mitochondrial bioenergetics and clinical development.

• Liu Y, et al. Application Research of Novel Peptide Mitochondrial-Targeted Antioxidant SS-31 in Mitigating Mitochondrial Dysfunction, Redox Report, 2024

A detailed review of SS-31’s mechanisms and analysis of 18 clinical trials across mitochondrial disorders and related diseases.

• Chatfield KC, et al. Elamipretide Improves Mitochondrial Function in the Failing Human Heart, JACC: Basic to Translational Science, 2019

Demonstrates improvements in mitochondrial function in human heart tissue and supports SS-31’s cardiolipin-targeted mechanism.

Συχνές Ερωτήσεις

What is SS-31?

SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively targets mitochondria by binding cardiolipin within the inner mitochondrial membrane. It is widely investigated for mitochondrial repair, cellular energy production and healthy aging research.

Why is SS-31 called a mitochondrial repair peptide?

Unlike most peptides that activate cell-surface receptors, SS-31 directly targets the inner mitochondrial membrane. Research suggests it helps preserve mitochondrial structure, improve bioenergetics and reduce oxidative stress in dysfunctional mitochondria.

How is SS-31 different from MOTS-c?

Both investigate mitochondrial biology, but MOTS-c primarily regulates metabolic signalling, whereas SS-31 focuses on the physical integrity and efficiency of the mitochondrial energy-producing machinery. They investigate complementary aspects of mitochondrial function.

What research areas commonly investigate SS-31?

Current research includes mitochondrial disease, cardiovascular physiology, skeletal muscle function, neurodegeneration, kidney injury, metabolic disorders and healthy aging.

Is SS-31 one of the more clinically studied peptides?

Yes. Compared with many research peptides, SS-31 has advanced into multiple Phase 2 and Phase 3 clinical programmes across several mitochondrial-related diseases, making it one of the best-studied mitochondrial peptides currently available.

Αυτό το προϊόν προορίζεται για ανθρώπινη χρήση;

No. SS-31 supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.

Σχετικό ερευνητικό πλαίσιο

SS-31 is frequently discussed alongside other research peptides investigating cellular energy, recovery and healthy aging, although each targets a different level of cellular physiology.

MOTS-c – investigated for metabolic signalling, exercise adaptation and mitochondrial communication.
Epitalon – studied for telomere biology, circadian regulation and healthy aging.
GHK-Cu – investigated for tissue repair, extracellular matrix remodelling and regenerative biology.
ARA-290 – focuses on innate tissue repair, inflammatory signalling and nerve regeneration.
CJC-1295 με DAC – investigated for sustained growth hormone and IGF-1 signalling that supports anabolic physiology.

Although these peptides are frequently associated with longevity and recovery research, SS-31 stands apart through its direct action on mitochondrial structure and bioenergetics rather than hormonal or metabolic signalling.

ΣΗΜΕΙΩΣΗ: Αυτό είναι μόνο για εκπαιδευτική αναφορά και δεν αποτελεί ιατρική συμβουλή.

Αποποίηση ευθύνης
Αυτό το προϊόν πωλείται αποκλειστικά για ερευνητικούς σκοπούς. Δεν προορίζεται για τη διάγνωση, θεραπεία, ίαση ή πρόληψη οποιασδήποτε ασθένειας. Ο αγοραστής αναλαμβάνει πλήρως την ευθύνη για τον σωστό χειρισμό και τη χρήση.