Descrizione
TB-500 is the name most commonly used within the research community for peptides derived from Thymosin β4 biology. Depending on the supplier and historical context, the term may refer to different peptide preparations. This product contains the complete Thymosin β4 (1–43) sequence, allowing researchers to investigate the full endogenous peptide rather than a shortened derivative.
Thymosin β4 is a naturally occurring 43-amino-acid peptide present in numerous human tissues. It plays important roles in actin regulation, cell migration, angiogenesis and tissue remodelling, making it one of the best-studied endogenous peptides in regenerative biology. Because TB-500 has become the dominant search term within the peptide community, the two names are frequently associated, even though they are not always scientifically identical.
Why TB-500 matters in regenerative research
TB-500 has become one of the most widely recognised regenerative peptides because published research on Thymosin β4 biology has demonstrated involvement in multiple repair-related processes rather than a single signalling pathway.
Research has investigated TB-500 / Thymosin β4 in relation to:
- tissue repair
- wound healing
- angiogenesi
- cell migration
- actin dynamics
- tendon and ligament biology
- skeletal muscle repair
- cardiac tissue research
- corneal regeneration
- segnalazione infiammatoria
Unlike peptides that primarily target a single receptor, Thymosin β4 influences several interconnected biological processes involved in tissue maintenance and repair, making it relevant across multiple fields of regenerative research.
How TB-500 works
The biological activity associated with TB-500 originates from Thymosin β4, an endogenous peptide that binds G-actin, helping regulate cytoskeletal organisation and cellular movement.
Published research has linked Thymosin β4 to:
- regulation of actin dynamics
- cell migration
- angiogenesi
- extracellular matrix remodelling
- inflammatory responses
- tissue regeneration
Because successful tissue repair depends on coordinated cell migration and structural remodelling, Thymosin β4 has become an important experimental model in regenerative medicine and wound-healing research.
Ricerca umana e preclinica
Published studies investigating Thymosin β4 have explored its biological activity across numerous laboratory models together with several early-stage human clinical programmes.
Research has examined its role in:
- dermal wound healing
- corneal repair
- myocardial injury
- pressure ulcers
- venous ulcers
- musculoskeletal regeneration
While early clinical studies reported encouraging biological activity and favourable tolerability, the current evidence base remains substantially smaller than that available for approved therapeutic agents. Consequently, TB-500 / Thymosin β4 continues to be investigated primarily as a research peptide rather than an established medicine.
Understanding TB-500 and full-sequence Thymosin β4
Although TB-500 is by far the most widely recognised name within the peptide community, the scientific literature primarily investigates Thymosin β4, the naturally occurring endogenous peptide.
This product contains the complete Thymosin β4 (1–43) sequence, consisting of all 43 amino acids found in the native human peptide.
This distinction matters because:
- many published mechanistic and clinical studies investigated the full-length peptide
- the term TB-500 has been used inconsistently by different suppliers over the years
- not every product marketed as TB-500 necessarily represents the complete endogenous sequence
For researchers seeking to align experimental work with the published Thymosin β4 literature, using the full-sequence peptide provides the closest match to the molecule investigated in most biological studies while still matching the terminology most researchers search for online.
How TB-500 differs from BPC-157 and GHK-Cu
Although TB-500, BPC-157 and GHK-Cu are frequently grouped together as regenerative peptides, they represent distinct biological approaches.
TB-500 / Thymosin β4 is primarily associated with cell migration, actin dynamics and tissue remodelling, making it particularly relevant for studies of coordinated tissue repair.
BPC-157 is more commonly investigated in tendon, ligament, muscle and gastrointestinal injury models, with particular interest in angiogenesis and cytoprotective signalling.
GHK-Cu is a naturally occurring copper peptide studied for extracellular matrix biology, collagen turnover, skin physiology and broad gene-regulatory effects.
Rather than competing with one another, these peptides are often viewed as complementary research tools targeting different aspects of regenerative biology.
Osservazioni di sicurezza pubblicate
Early human clinical studies investigating full-sequence Thymosin β4 have generally reported favourable tolerability under controlled research conditions.
Phase I clinical programmes evaluating intravenous administration found no dose-limiting toxicity within the investigated dose ranges, while subsequent studies continued to evaluate safety in cardiovascular, ophthalmic and tissue-repair settings.
Because published human data remain relatively limited and involve different formulations and research objectives, current safety findings should be interpreted within the context of each individual study.
Caratteristiche del prodotto
Applicazione: ricerca di laboratorio e analitica
Uso limitato: non per il consumo umano; non per uso medico, veterinario o cosmetico
Prodotto in stabilimenti conformi alle GMP secondo rigidi protocolli di controllo qualità.
Ogni lotto viene accuratamente testato in laboratorio dopo la produzione (puoi trovare il Certificato di Analisi sotto le immagini del prodotto).
Liofilizzato (liofilizzato) per la massima stabilità e una lunga durata di conservazione.
Sigillato in fiale sterili, pronto per la ricostituzione.
Purity: ≥ 99% (HPLC)
Aspetto: polvere liofilizzata bianca
Formula molecolare: C212H350N56 O78S
Molecular weight: 4963.49
CAS No: 77591-33-4
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Archiviazioneflaconcini liofilizzati non aperti sono meglio conservati refrigerato a 2–8°C, che è il metodo di conservazione confermato dal nostro partner di produzione e adatto fino a 24 mesi. Si preferisce la refrigerazione perché minimizza inutili cicli di congelamento-scongelamento durante la manipolazione di routine. Se è necessaria una conservazione a termine sostanzialmente più lungo, i flaconcini liofilizzati non aperti possono anche essere conservati congelati. Una volta ricostituita, conservare sempre a 2-8°C e non congelare.
Ricostituzione e manipolazione
TB-500 is supplied as a lyophilised peptide and should be reconstituted using appropriate laboratory procedures suitable for peptide research. To help preserve structural integrity, add the chosen solvent slowly against the inside wall of the vial rather than directly onto the peptide cake, and avoid vigorous shaking. Gentle swirling is generally sufficient once the peptide has fully dissolved. Standard laboratory practice also includes allowing refrigerated vials to reach room temperature before reconstitution to minimise condensation inside the vial.
Most often TB-500 is reconstituted with acqua batteriostatica before use. For sterile filtration of peptide solutions it is advised to use a 0.22 µm PES syringe filter. For other solvent selection, concentration planning and storage guidance, see the full Guida alla Ricostituzione dei Peptidi e Calcolatore di Ricostituzione.. These resources explain how different reconstitution volumes affect working concentration without recommending research protocols.
Studi chiave pubblicati
- Goldstein AL, Kleinman HK. Thymosin β4: Structure, Function and Biological Properties Supporting Current and Future Clinical Applications. Annals of the New York Academy of Sciences, 2010.
A landmark review describing the biological functions of full-sequence Thymosin β4, including tissue repair, angiogenesis, inflammation and regenerative medicine.
- Ruff D, Crockford D, Girardi G, et al. A Randomized, Placebo-Controlled, Single and Multiple Dose Study of Intravenous Thymosin β4 in Healthy Volunteers. Annals of the New York Academy of Sciences, 2010.
The first Phase I human study evaluating the safety, tolerability and pharmacological profile of full-sequence Thymosin β4.
- Xing Y, Zhang Y, Li Y, et al. Progress on the Function and Application of Thymosin β4. International Journal of Molecular Sciences, 2021.
A comprehensive review covering actin regulation, angiogenesis, wound healing, inflammation and current directions in regenerative research.
- Wang X, Liu L, Qi L, et al. A First-in-Human, Randomized, Double-Blind, Single- and Multiple-Dose Phase I Study of Recombinant Human Thymosin β4 in Healthy Chinese Volunteers. Journal of Cellular and Molecular Medicine, 2021.
A modern Phase I study describing safety, pharmacokinetics and tolerability of recombinant full-sequence Thymosin β4 in healthy volunteers.
Domande frequenti
What is TB-500?
TB-500 is the name most commonly used within the peptide research community for peptides associated with Thymosin β4 biology. This product contains the complete Thymosin β4 (1–43) sequence, allowing researchers to investigate the full endogenous peptide.
Is TB-500 the same as Thymosin β4?
The names are often used interchangeably, but they are not always scientifically equivalent. Thymosin β4 is the naturally occurring 43-amino-acid peptide found in human tissues, while the term TB-500 has historically been applied to different research peptide preparations. This product contains the full-length Thymosin β4 sequence.
Why does the full sequence matter?
Many published mechanistic and clinical studies have investigated the complete endogenous Thymosin β4 molecule. Using the full 43-amino-acid sequence allows researchers to work with a peptide that most closely reflects the molecule described throughout the scientific literature.
What research areas commonly investigate TB-500?
Published studies have investigated Thymosin β4 biology in tissue repair, wound healing, angiogenesis, cell migration, tendon and ligament research, cardiac repair, corneal regeneration and regenerative medicine.
How does TB-500 differ from BPC-157?
Although both peptides are widely studied in regenerative research, TB-500 is primarily associated with actin regulation, cell migration and tissue remodelling, whereas BPC-157 is more commonly investigated in soft-tissue injury models, angiogenesis and cytoprotective signalling.
Questo prodotto è destinato all'uso umano?
No. TB-500 (Full Sequence Thymosin β4) supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the scientific literature relating to the peptide rather than the intended use of this product.
Contesto di ricerca correlato
Thymosin β4 belongs to the healing & recovery peptide research cluster, focused on tissue signaling, cellular repair mechanisms, and inflammatory pathway modulation.
Researchers studying these pathways may also examine:
BPC-157 – tissue signaling peptide
GHK-Cu – copper peptide complex
KPV – anti-inflammatory peptide fragment
ARA-290 – erythropoietin-derived peptide
SS-31 – indagata per la funzione mitocondriale e la produzione di energia cellulare.
For broader context, see the Healing & recovery research guide.
Sfoglia tutti i composti in Healing & recovery research category.
NOTA: Questo è solo a scopo didattico e non costituisce parere medico.
This product is supplied as full-sequence Thymosin β4 (1–43)
Not labeled or marketed as “TB-500” to avoid ambiguity
Intended strictly for controlled laboratory environments
Disclaimer
Questo prodotto è venduto esclusivamente a scopo di ricerca. Non è destinato a diagnosticare, trattare, curare o prevenire alcuna malattia. L'acquirente si assume la piena responsabilità per la corretta manipolazione e utilizzo.
Recensioni
Ancora non ci sono recensioni.