CJC-1295 s DAC / 2 mg

Description

CJC-1295 with DAC is a modified analogue of Growth Hormone Releasing Hormone (GHRH) engineered to dramatically extend its duration of action.

Unlike CJC-1295 no DAC (Modified GRF 1-29), which is cleared relatively quickly, the DAC version contains a Drug Affinity Complex that binds reversibly to circulating albumin. This prolongs circulation from approximately 30 minutes to several days, allowing researchers to investigate sustained stimulation of the growth hormone axis.

Because of this unique pharmacokinetic profile, CJC-1295 with DAC has become one of the most widely investigated long-acting GHRH analogues in endocrine and metabolism research.

Why CJC-1295 with DAC is widely investigated

Published research has investigated CJC-1295 with DAC in relation to:

• sustained growth hormone signalling
• Regulace IGF-1
• healthy aging research
• body composition
• muscle physiology
• recovery biology
• protein metabolism
• fyziologie endokrinního systému
• Signalizace receptoru GHRH

Unlike short-acting GHRH analogues, the DAC version is primarily investigated for maintaining prolonged GH and IGF-1 elevation rather than generating brief physiological pulses.

How CJC-1295 with DAC works

Drug Affinity Complex (DAC)

The defining feature of this peptide is the Drug Affinity Complex, which enables reversible binding to serum albumin. Albumin binding protects the peptide from rapid degradation and renal clearance, extending its biological activity for several days.

Growth hormone release

CJC-1295 with DAC activates GHRH receptors in the pituitary gland, stimulating endogenous growth hormone secretion. Because the peptide remains in circulation much longer than the No DAC version, published studies have reported sustained increases in circulating GH and IGF-1.

IGF-1 research

One of the principal reasons for developing CJC-1295 with DAC was to achieve prolonged elevation of IGF-1, allowing researchers to investigate the effects of sustained GHRH signalling on metabolism and tissue physiology.

Endokrinní fyziologie

Researchers have also investigated how prolonged GHRH receptor activation differs from physiological pulsatile secretion, making CJC-1295 with DAC an important tool in comparative endocrine research.

Why CJC-1295 with DAC differs from CJC-1295 No DAC

Although they share the same peptide backbone, CJC-1295 with DAC and CJC-1295 No DAC are pharmacologically distinct compounds.

CJC-1295 s DAC

• Long-acting (approximately 5–8-day half-life)
• Sustained GH and IGF-1 elevation
• Albumin binding through the Drug Affinity Complex
• Designed for prolonged endocrine stimulation

CJC-1295 no DAC (Modified GRF 1-29)

• Short-acting (approximately 30-minute half-life)
• Fyziologické pulzy GH
• Rapid clearance
• Designed to mimic natural GHRH secretion

For this reason, the two peptides are not interchangeable and are often selected for different research objectives.

Lidský a preklinický výzkum

CJC-1295 with DAC has progressed into early human clinical investigation.

Published studies demonstrated prolonged increases in circulating growth hormone and IGF-1 following administration, confirming that the Drug Affinity Complex successfully extends biological activity compared with conventional GHRH analogues. Research continues to explore applications in endocrinology, metabolism and healthy aging.

Publikované bezpečnostní poznatky

Early clinical studies generally reported favourable tolerability. The most frequently reported adverse events included mild injection-site reactions and transient flushing. Researchers also noted prolonged elevations of GH and IGF-1 consistent with the peptide’s extended half-life, which distinguishes it from the shorter-acting No DAC formulation.

Vlastnosti produktu

Aplikace: laboratorní a analytický výzkum
Použití omezené: není určeno k lidské spotřebě; pro lékařské, veterinární ani kosmetické použití
Vyrobeno v zařízeních splňujících správnou výrobní praxi (GMP) za přísných protokolů kontroly kvality.
Každá šarže je po výrobě pečlivě laboratorně testována (Certifikát o analýze najdete pod obrázky produktů).
Lyofilizováno (sušeno mrazem) pro maximální stabilitu a prodlouženou trvanlivost.
Uzavřeno ve sterilních lahvičkách, připraveno k rekonstituci.
Purity: ≥ 99.64% , HPLC tested
Vzhled: bílý lyofilizovaný prášek
Molekulární vzorec: C₁₆₅H₂₆₉N₄₇O₄₆
Molecular weight: 3647.65

ÚložištěNeotevřené lyofilizované lahvičky jsou nejlépe skladovány chlazené při 2–8 °C, což je metoda skladování potvrzená naším výrobním partnerem a vhodná až po dobu 24 měsíců. Preferuje se chlazení, protože minimalizuje zbytečné cykly zmrazování a rozmrazování během běžné manipulace. Pokud je vyžadováno podstatně delší skladování, lze zmrazené uchovávat i neotevřené lyofilizované lahvičky. Po rekonstituci vždy skladujte při 2–8 °C a nezmrazujte.

Rekonstituce a manipulace

CJC-1295 je dodáván v lyofilizované lahvičce a měl by být zpracováván pomocí standardních postupů pro rekonstituci peptidů vhodných pro výzkumné prostředí. Musí být rekonstituován s bakteriostatická voda před použitím. Pro zachování strukturální integrity přidejte zvolené rozpouštědlo pomalu po vnitřní stěně lahvičky namísto přímo na peptidový prášek a vyhněte se prudkému protřepávání. Jemné kroužení je obecně dostačující, jakmile se peptid zcela rozpustí. Standardní laboratorní postupy zahrnují také ponechání chlazených lahviček dosáhnout pokojové teploty před rekonstitucí, aby se minimalizovala kondenzace uvnitř lahvičky.

Pro další pokyny k výběru rozpouštědla, plánování koncentrací a skladování viz úplné Průvodce rekonstitucí peptidů a Kalkulačka rekonstituce.

Vybrané výzkumné reference

• Teichman SL, et al. Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, Journal of Clinical Endocrinology & Metabolism, 2006

The landmark first-in-human study demonstrating prolonged increases in GH and IGF-1 following administration of CJC-1295 with DAC.

• Drug Affinity Complex pharmacology

Research describing albumin binding, extended half-life and pharmacokinetics of CJC-1295 with DAC compared with short-acting Modified GRF (1-29).

• Modern comparative reviews

Recent reviews summarising the pharmacological differences between CJC-1295 with DAC and CJC-1295 No DAC, with emphasis on sustained versus pulsatile GH signalling.

Často kladené otázky

What is CJC-1295 with DAC?

CJC-1295 with DAC is a long-acting analogue of growth hormone-releasing hormone (GHRH). The attached Drug Affinity Complex extends its circulation time, making it widely investigated for sustained GH and IGF-1 signalling.

What does DAC mean?

DAC stands for Drug Affinity Complex, a chemical modification that enables reversible albumin binding and dramatically prolongs the peptide’s half-life.

How is CJC-1295 with DAC different from No DAC?

The DAC version provides prolonged GH and IGF-1 elevation, whereas CJC-1295 No DAC (Modified GRF 1-29) produces short-lived, physiological GH pulses. They are different research tools rather than different strengths of the same peptide.

Why is CJC-1295 with DAC investigated for IGF-1?

Its extended duration of action allows researchers to study sustained stimulation of the GH/IGF-1 axis over several days rather than transient hormone pulses.

Can CJC-1295 with DAC be combined with other GH peptides?

In published research, CJC-1295 with DAC has often been discussed alongside peptides that stimulate growth hormone through complementary mechanisms, including Ipamorelin. The combination is investigated because the peptides act through different receptor systems, although each retains a distinct pharmacological profile.

Je tento produkt určen k lidskému použití?

No. CJC-1295 with DAC supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.

Související výzkumný kontext

CJC-1295 with DAC is frequently discussed alongside other research peptides investigating growth hormone signalling, recovery and healthy aging.

CJC-1295 no DAC (Modified GRF 1-29) – investigated for physiological pulsatile growth hormone release and short-duration GHRH signalling.
Ipamorelin – studied as a selective ghrelin receptor agonist that stimulates endogenous growth hormone release through a complementary pathway.
Tesamorelin – investigated as a clinically validated GHRH analogue with established endocrine research.
MOTS-c – focuses on mitochondrial metabolism, exercise adaptation and healthy aging rather than direct GH signalling.
Epitalon – investigated for telomere biology, circadian regulation and longevity research.
SS-31 – investigated for mitochondrial function and cellular bioenergetics.

Although these peptides are often grouped within performance and healthy aging research, CJC-1295 with DAC is distinguished by its sustained activation of the growth hormone axis, whereas the others target different biological pathways.

POZNÁMKAToto je pouze pro vzdělávací účely a nepředstavuje lékařskou radu.

Zřeknutí se odpovědnosti
Tento produkt je prodáván pouze pro výzkumné účely. Není určen k diagnostice, léčbě, vyléčení nebo prevenci jakýchkoli onemocnění. Kupující přebírá plnou odpovědnost za řádnou manipulaci a použití.