Melanotan 2 (MT2) / 10 mg

Περιγραφή

Melanotan 2 (also known as Melanotan II or MT2) is one of the best-known research peptides for tanning and pigmentation studies. It is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH), developed to investigate how melanocortin signalling regulates melanin production and the skin’s physiological response to ultraviolet (UV) exposure.

Beyond pigmentation research, Melanotan 2 has played an important role in advancing our understanding of the melanocortin system. During early clinical investigations, researchers observed effects beyond skin pigmentation, leading to the later development of PT-141 (Bremelanotide), a more selective melanocortin peptide designed specifically for sexual function research.

Today, Melanotan 2 remains one of the most extensively investigated peptides for pigmentation biology, melanocortin receptor signalling and neuroendocrine physiology.

Why Melanotan 2 is widely investigated

Published research has investigated Melanotan 2 in relation to:

• tanning research
• skin pigmentation
• melanin production
• melanogenesis
• UV-independent pigmentation
• melanocyte biology
• melanocortin receptor signalling
• appetite regulation
• neuroendocrine physiology

Its broad receptor activity has made Melanotan 2 one of the foundational research peptides for understanding the melanocortin system.

How Melanotan 2 promotes pigmentation

Published research demonstrates that Melanotan 2 primarily activates the MC1 melanocortin receptor, which regulates melanin production within melanocytes.

Research has explored its relationship with:

Melanin production

Activation of melanocytes and increased melanin synthesis, making Melanotan 2 one of the best-known peptides in pigmentation research.

UV response

Investigation of the relationship between melanocortin signalling, melanin production and the skin’s physiological response to ultraviolet exposure.

Pigmentation biology

Studies examining how melanocortin receptors regulate pigmentation across different skin types and experimental models.

Because Melanotan 2 also activates other melanocortin receptors, researchers have investigated additional physiological pathways involving appetite regulation, energy balance and central nervous system signalling.

Why Melanotan 2 became important beyond tanning research

Although Melanotan 2 was originally developed for pigmentation research, investigators later discovered that melanocortin receptor activation also influenced central nervous system pathways involved in sexual behaviour.

These findings ultimately led to the development of PT-141 (Bremelanotide), a more selective melanocortin peptide that focuses on sexual desire and arousal research rather than pigmentation.

This makes Melanotan 2 one of the most influential peptides in the history of melanocortin research.

Ανθρώπινη και προκλινική έρευνα

Melanotan 2 has been investigated extensively in both laboratory and human studies.

Published research includes:

• tanning physiology
• pigmentation biology
• melanogenesis
• UV response
• melanocortin receptor pharmacology
• appetite regulation
• neuroendocrine signalling

Although newer melanocortin analogues have since been developed for more specific applications, Melanotan 2 remains one of the principal research compounds for studying the melanocortin receptor family.

How Melanotan 2 differs from related peptides

Although Melanotan 2 and PT-141 share a common developmental history, they are now investigated for different research objectives. Melanotan 2 primarily focuses on pigmentation and melanocortin biology, whereas PT-141 investigates central pathways involved in sexual desire and arousal.

Δημοσιευθείσες παρατηρήσεις ασφαλείας

Published human studies have most commonly reported nausea, facial flushing, yawning and transient increases in skin pigmentation. Researchers have also observed increased pigmentation of freckles and existing moles, which has become an area of continued investigation. Current knowledge is based primarily on controlled clinical studies and experimental research, and long-term safety remains an active topic within the scientific literature.

Χαρακτηριστικά προϊόντος

Εφαρμογή: εργαστηριακή και αναλυτική έρευνα
Χρήση περιορισμού: όχι για ανθρώπινη κατανάλωση· όχι για ιατρική, κτηνιατρική ή καλλυντική χρήση
Παράγεται σε εγκαταστάσεις που συμμορφώνονται με τις ΟGMP υπό αυστηρά πρωτόκολλα ΠΚ.
Κάθε παρτίδα ελέγχεται προσεκτικά στο εργαστήριο μετά την παραγωγή (μπορείτε να βρείτε το Πιστοποιητικό Ανάλυσης κάτω από τις εικόνες του προϊόντος).
Κατάψυξη-αποξήρανση (λυσόφιλη) για μέγιστη σταθερότητα και παρατεταμένη διάρκεια ζωής.
Σφραγισμένα σε αποστειρωμένες φιάλες, έτοιμα για ανασύσταση.
Purity: ≥ 99% (HPLC)
Εμφάνιση: λευκή λυοφιλοποιημένη σκόνη
Μοριακός τύπος: C₅₀H₆₉N₁₅O₉
Molecular weight: 1024.2
CAS No: 121062-08-6

Αποθήκευση: τα αφυδατωμένα σε ξηρή ψύξη, σφραγισμένα φιαλίδια φυλάσσονται καλύτερα συντήρηση στους 2–8°C, η οποία είναι η μέθοδος αποθήκευσης που επιβεβαιώθηκε από τον συνεργάτη παραγωγής μας και είναι κατάλληλη για έως και 24 μήνες. Η ψύξη προτιμάται επειδή ελαχιστοποιεί τους περιττούς κύκλους ψύξης-απόψυξης κατά τον συνήθη χειρισμό. Εάν απαιτείται σημαντικά μακροχρόνια αποθήκευση, τα σφραγισμένα λυοφιλοποιημένα φιαλίδια μπορούν επίσης να διατηρηθούν κατεψυγμένα. Μόλις ανασυσταθεί, αποθηκεύετε πάντα σε 2–8°C και μην καταψύχετε.

Ανα

Melanotan 2 is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with Βακτηριοστατικό νερό πριν τη χρήση. Για να διατηρηθεί η δομική ακεραιότητα, προσθέστε το επιλεγμένο διαλύτη αργά στο εσωτερικό τοίχωμα του φιαλιδίου αντί απευθείας στη μάζα του πεπτιδίου, και αποφύγετε το έντονο ανακίνημα. Η απαλή περιστροφή είναι γενικά επαρκής μόλις το πεπτίδιο διαλυθεί πλήρως. Η τυπική εργαστηριακή πρακτική περιλαμβάνει επίσης την αναμονή των ψυχόμενων φιαλιδίων να φτάσουν σε θερμοκρασία δωματίου πριν από την ανασύσταση για να ελαχιστοποιηθεί η συμπύκνωση στο εσωτερικό του φιαλιδίου.

Για την επιλογή άλλων διαλυτών, σχεδιασμό συγκεντρώσεων και οδηγίες αποθήκευσης, δείτε το πλήρες Οδηγός Ανασύστασης Πεπτιδίων και Υπολογιστής Απεικόνισης.

Επιλεγμένες ερευνητικές αναφορές

• Hadley ME. Melanocortin Peptide Therapeutics: Historical Milestones, Clinical Studies and Commercialization, Peptides, 2006

A comprehensive review describing the development of Melanotan peptides, pigmentation research and the subsequent evolution of PT-141 from Melanotan 2.

• Dorr RT, et al. Evaluation of Melanotan-II, a Superpotent Cyclic Melanotropic Peptide in a Pilot Phase I Clinical Study, Life Sciences, 1996

The first human clinical study evaluating Melanotan 2 and its effects on pigmentation.

• Habbema L, Halk AB, Neumann M, Bergman W. Risks of Unregulated Use of Alpha-Melanocyte-Stimulating Hormone Analogues: A Review, International Journal of Dermatology, 2017

A review summarising the published evidence on Melanotan analogues, pigmentation effects and reported safety considerations.

• Wessells H, et al. Melanocortin Receptor Agonists and Human Sexual Function, International Journal of Impotence Research, 2000

One of the early human studies showing central nervous system effects beyond pigmentation, contributing to the later development of PT-141.

Συχνές Ερωτήσεις

What is Melanotan 2?

Melanotan 2 is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH). It is one of the world’s most extensively investigated research peptides for tanning, pigmentation and melanocortin receptor biology.

How does Melanotan 2 promote pigmentation?

Melanotan 2 primarily activates the MC1 melanocortin receptor, which regulates melanin production within melanocytes. This has made it one of the leading research peptides for pigmentation and tanning studies.

How does Melanotan 2 differ from PT-141?

Although PT-141 was developed from Melanotan 2, the two peptides are investigated for different purposes. Melanotan 2 primarily focuses on pigmentation and melanocortin biology, while PT-141 is a more selective melanocortin peptide investigated mainly for sexual desire and arousal research.

Why is Melanotan 2 associated with appetite and sexual function research?

Melanotan 2 activates several melanocortin receptor subtypes in addition to MC1R, including receptors involved in appetite regulation and central nervous system signalling. Early studies unexpectedly observed effects on sexual function, which contributed to the later development of PT-141.

What research areas commonly investigate Melanotan 2?

Published research includes tanning physiology, skin pigmentation, melanogenesis, UV response, melanocortin receptor signalling, appetite regulation and neuroendocrine physiology.

How does Melanotan 2 differ from Melanotan 1 (Afamelanotide)?

Both peptides are derived from α-MSH, but Melanotan 2 activates multiple melanocortin receptor subtypes, whereas Afamelanotide is considerably more selective for MC1R. This broader receptor activity has made Melanotan 2 useful across a wider range of melanocortin research topics.

Αυτό το προϊόν προορίζεται για ανθρώπινη χρήση;

No. Melanotan 2 supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the current scientific literature relating to the Melanotan 2 molecule rather than the intended use of this product.

Σχετικό ερευνητικό πλαίσιο

Melanotan 2 belongs to the broader Melanocortin and neuroendocrine peptide research category, focusing on pigmentation pathways and central melanocortin signaling mechanisms.
Researchers exploring related melanocortin pathway models may also examine:
• PT-141 (Bremelanotide) — selective melanocortin receptor signaling research
• Cognitive & neuroresearch peptides — CNS peptide signaling models

ΣΗΜΕΙΩΣΗ: Αυτό είναι μόνο για εκπαιδευτική αναφορά και δεν αποτελεί ιατρική συμβουλή.

Αποποίηση ευθύνης
Αυτό το προϊόν πωλείται αποκλειστικά για ερευνητικούς σκοπούς. Δεν προορίζεται για τη διάγνωση, θεραπεία, ίαση ή πρόληψη οποιασδήποτε ασθένειας. Ο αγοραστής αναλαμβάνει πλήρως την ευθύνη για τον σωστό χειρισμό και τη χρήση.