GHK-Cu

Description

A naturally occurring copper peptide widely studied in regenerative biology

GHK-Cu is a copper-binding tripeptide found naturally within human plasma, saliva, and other tissues. It has been extensively investigated for its involvement in cellular repair mechanisms, extracellular matrix remodeling, collagen-related signaling, and tissue regeneration pathways.
As one of the most researched compounds within regenerative peptide science, GHK-Cu has attracted interest across skin biology, wound-healing research, connective tissue studies, and hair follicle investigations.

Research overview

GHK-Cu consists of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine complexed with copper ions. Researchers have explored this molecule for decades due to its apparent role in biological signaling processes associated with tissue maintenance and repair.
Published studies have investigated GHK-Cu in relation to:

• Collagen and extracellular matrix regulation
• Skin remodeling and dermal biology
• Tissue recovery signaling pathways
• Cellular repair mechanisms
• Hair follicle and scalp biology research
• Oxidative stress response pathways
• Gene expression associated with regeneration

Unlike many synthetic research peptides, GHK-Cu occurs naturally in the human body, making it a unique subject within regenerative research.

Product characteristics

Purity: ≥ 99% HPLC tested, independently confirmed high purity and identity consistency. View third-party verification.
Appearance: Blue lyophilized powder
Molecular formula: C₁₄H₂₂CuN₆O₄
Molecular weight: 403.9 g/mol
Sequence: Gly-His-Lys:Cu（1:1,HOAc）
Storage: store lyophilized powder at -20°C, protect from light and moisture. Reconstituted solution should be kept at 2–8°C and used within a short period.

Why choose our GHK Cu?

High purity verified by HPLC.
Produced in GMP-compliant facilities under strict QC protocols.
Each batch carefully lab tested after production (you can find Certificate of Analysis under product pictures).
Freeze-dried (lyophilized) for maximum stability and extended shelf life.
Sealed in sterile vials, ready for reconstitution.

Selected research references

• Pickart L, Margolina A. “GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.” BioMed Research International. 2015.
• Pickart L, Margolina A, Regland B. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” International Journal of Molecular Sciences. 2018.
• Pickart L, Margolina A. “GHK-Cu May Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes.” Cosmetics. 2015.
• Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. “Stimulation of Collagen Synthesis in Fibroblast Cultures by the Tripeptide-Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+.” FEBS Letters. 1988.

Related research context

GHK-Cu is part of the regenerative peptide and extracellular matrix (ECM) remodeling research class, commonly studied in models involving collagen synthesis, tissue regeneration, and metalloproteinase regulation. For broader context on angiogenesis, tissue repair pathways, and multi-compound interactions, see our Healing & recovery research guide.

For mechanistic comparison with cytoprotective and migration-modulating peptides, see our Copper peptides & tissue repair guide.

Browse all compounds in the Healing & recovery research category.

Researchers investigating tissue remodeling, repair signaling, and multi-pathway regeneration may also examine:

• BPC-157 – peptide associated with angiogenesis and tissue repair pathways
• Tb4 (Thymosin Beta-4 full sequence, aka TB500) – actin regulation and cellular migration
• KPV (α-MSH fragment) – inflammation-modulating peptide fragment

NOTE: This is for educational reference only and does not constitute medical advice.

Disclaimer
This product is sold for research purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Buyer assumes full responsibility for proper handling and use.