MOTS-c 10 mg

Description

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring 16-amino-acid mitochondrial-derived peptide encoded by mitochondrial DNA rather than the nuclear genome. This unique origin distinguishes it from most other research peptides and has made it an important molecule for investigating how mitochondria communicate with the rest of the cell.

Published research suggests that MOTS-c is released in response to metabolic stress and exercise, where it helps coordinate cellular adaptation to increased energy demand. Because of this role, MOTS-c has become one of the leading investigational peptides in metabolism, exercise physiology and healthy aging research.

Why MOTS-c is widely investigated

Published research has investigated MOTS-c in relation to:

• cellular energy metabolism
• exercise adaptation
• mitochondrial function
• metabolic flexibility
• insulin sensitivity
• glucose metabolism
• healthy aging
• skeletal muscle physiology
• AMPK signalling

As research into mitochondrial-derived peptides has expanded, MOTS-c has become one of the best-characterised molecules linking mitochondrial function with whole-body metabolism.

How MOTS-c works

Unlike conventional peptide hormones, MOTS-c functions as a mitochondrial signalling peptide, helping cells adapt to metabolic stress.

Publikovaný výzkum zkoumal jeho vztah s:

Cellular energy metabolism

MOTS-c has been investigated for its ability to regulate cellular energy use during metabolic stress by influencing pathways involved in glucose utilisation and fatty acid metabolism.

Exercise adaptation

Exercise increases endogenous MOTS-c expression, making it one of the most studied mitochondrial-derived peptides in exercise physiology. Researchers have investigated whether MOTS-c contributes to some of the metabolic adaptations normally associated with physical activity.

AMPK signalling

One of the principal mechanisms investigated for MOTS-c involves activation of AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance and metabolic adaptation.

Healthy aging

Because mitochondrial function changes with age, MOTS-c has become an important research target in studies investigating metabolic resilience and healthy aging.

Why MOTS-c is often described as an “exercise peptide”

One of the most interesting observations in the scientific literature is that endogenous MOTS-c levels increase in response to exercise.

Rather than replacing physical activity, researchers are investigating whether MOTS-c activates some of the same cellular pathways involved in exercise-induced metabolic adaptation, particularly those related to mitochondrial function and AMPK signalling. This has led to its description as a potential exercise-mimetic peptide, although this remains an active area of research and should not be interpreted as equivalent to the physiological effects of exercise itself.

Lidský a preklinický výzkum

Research on MOTS-c is growing rapidly, although the evidence base remains considerably smaller than for established metabolic peptides such as Semaglutide or Tirzepatide.

Published studies have investigated MOTS-c in laboratory models of metabolism, exercise physiology, insulin sensitivity and aging, while human research has primarily focused on endogenous MOTS-c levels and their relationship with metabolic health. Clinical interventional research remains limited.

How MOTS-c differs from related metabolic peptides

Unlike incretin peptides, MOTS-c is investigated primarily for cellular energy regulation and mitochondrial signalling, making it one of the few research peptides that directly targets mitochondrial biology.

Publikované bezpečnostní poznatky

Most published data on MOTS-c come from preclinical studies, with relatively limited human interventional research available. Current investigations have generally reported acceptable tolerability in early studies, but long-term efficacy and safety remain under investigation. Because clinical evidence is still emerging, findings should be interpreted within the context of ongoing research.

Vlastnosti produktu

Aplikace: laboratorní a analytický výzkum
Použití omezené: není určeno k lidské spotřebě; pro lékařské, veterinární ani kosmetické použití
Vyrobeno v zařízeních splňujících správnou výrobní praxi (GMP) za přísných protokolů kontroly kvality.
Každá šarže je po výrobě pečlivě laboratorně testována (Certifikát o analýze najdete pod obrázky produktů).
Lyofilizováno (sušeno mrazem) pro maximální stabilitu a prodlouženou trvanlivost.
Uzavřeno ve sterilních lahvičkách, připraveno k rekonstituci.
Purity: ≥98% (HPLC-tested)
Appearance: Lyophilized white/off-white powder
Molekulární vzorec: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight: 2174.6
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

ÚložištěNeotevřené lyofilizované lahvičky jsou nejlépe skladovány chlazené při 2–8 °C, což je metoda skladování potvrzená naším výrobním partnerem a vhodná až po dobu 24 měsíců. Preferuje se chlazení, protože minimalizuje zbytečné cykly zmrazování a rozmrazování během běžné manipulace. Pokud je vyžadováno podstatně delší skladování, lze zmrazené uchovávat i neotevřené lyofilizované lahvičky. Po rekonstituci vždy skladujte při 2–8 °C a nezmrazujte.

Rekonstituce a manipulace

MOTS-c is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with bakteriostatická voda před použitím. Pro zachování strukturální integrity přidejte zvolené rozpouštědlo pomalu po vnitřní stěně lahvičky namísto přímo na peptidový prášek a vyhněte se prudkému protřepávání. Jemné kroužení je obecně dostačující, jakmile se peptid zcela rozpustí. Standardní laboratorní postupy zahrnují také ponechání chlazených lahviček dosáhnout pokojové teploty před rekonstitucí, aby se minimalizovala kondenzace uvnitř lahvičky.

Pro další pokyny k výběru rozpouštědla, plánování koncentrací a skladování viz úplné Průvodce rekonstitucí peptidů a Kalkulačka rekonstituce.

Vybrané výzkumné reference

• Lee C, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance, Cell Metabolism, 2015

The landmark paper describing the discovery of MOTS-c and its role in metabolic regulation.

• Zhou H, et al. Mitochondria-derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging, Journal of Translational Medicine, 2023

A comprehensive review summarising current evidence on MOTS-c biology, metabolism, stress adaptation and aging.

• Atakan MM, Bishop DJ. Small Peptides: Could They Have a Big Role in Metabolism and the Response to Exercise?, Journal of Physiology, 2024

A modern review examining mitochondrial-derived peptides, including MOTS-c, with a focus on exercise physiology and metabolic adaptation.

• Bobylev AG, et al. Mitochondrial Peptide MOTS-c: Regulation of Metabolism and Prospects for Clinical and Sports Medicine Applications, Human Physiology, 2025

A review discussing emerging evidence for MOTS-c in metabolism, exercise physiology and healthy aging.

Často kladené otázky

What is MOTS-c?

MOTS-c is a naturally occurring mitochondrial-derived peptide encoded by mitochondrial DNA. It is widely investigated for its role in cellular energy metabolism, exercise adaptation and healthy aging.

Why is MOTS-c associated with exercise research?

Published studies have shown that endogenous MOTS-c levels increase in response to exercise. Researchers are investigating whether it contributes to metabolic adaptations associated with physical activity through pathways such as AMPK signalling.

What makes MOTS-c different from GLP-1 peptides?

Unlike GLP-1 receptor agonists, which primarily investigate incretin signalling, MOTS-c focuses on mitochondrial communication, cellular energy regulation and metabolic adaptation. These represent distinct areas of metabolic research.

What research areas commonly investigate MOTS-c?

Current research includes cellular metabolism, mitochondrial biology, insulin sensitivity, exercise physiology, AMPK signalling, skeletal muscle adaptation and healthy aging.

How does MOTS-c differ from SS-31?

Both are mitochondrial peptides, but they investigate different aspects of mitochondrial biology. MOTS-c is primarily associated with metabolic signalling and exercise adaptation, whereas SS-31 is investigated for mitochondrial membrane integrity and bioenergetics.

Is MOTS-c an exercise replacement?

No. Although MOTS-c has been described as an exercise-mimetic peptide because it activates some exercise-related metabolic pathways, current research does not support the conclusion that it reproduces the full physiological effects of physical exercise.

Je tento produkt určen k lidskému použití?

No. MOTS-c supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the scientific literature relating to the MOTS-c molecule rather than the intended use of this product.

Související výzkumný kontext

MOTS-c is frequently discussed alongside other research peptides investigating mitochondrial function, metabolism and healthy aging, although each targets different aspects of cellular physiology.

SS-31 (Elamipretide) – investigated for mitochondrial repair and cellular energy production.
Epitalon – studied for telomere biology and healthy aging research.
CJC-1295 s DAC – investigated for sustained GH and IGF-1 signalling.
CJC-1295 bez DAC – studied for physiological growth hormone release.
GHK-Cu – investigated for tissue regeneration and extracellular matrix remodelling.

NOTE: This is for educational reference only and does not constitute medical advice.

Disclaimer:
Tento produkt je prodáván pouze pro výzkumné účely. Není určen k diagnostice, léčbě, vyléčení nebo prevenci jakýchkoli onemocnění. Kupující přebírá plnou odpovědnost za řádnou manipulaci a použití.