MOTS-c 10 mg

Περιγραφή

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring 16-amino-acid mitochondrial-derived peptide encoded by mitochondrial DNA rather than the nuclear genome. This unique origin distinguishes it from most other research peptides and has made it an important molecule for investigating how mitochondria communicate with the rest of the cell.

Published research suggests that MOTS-c is released in response to metabolic stress and exercise, where it helps coordinate cellular adaptation to increased energy demand. Because of this role, MOTS-c has become one of the leading investigational peptides in metabolism, exercise physiology and healthy aging research.

Why MOTS-c is widely investigated

Published research has investigated MOTS-c in relation to:

• cellular energy metabolism
• exercise adaptation
• mitochondrial function
• metabolic flexibility
• insulin sensitivity
• glucose metabolism
• healthy aging
• skeletal muscle physiology
• AMPK signalling

As research into mitochondrial-derived peptides has expanded, MOTS-c has become one of the best-characterised molecules linking mitochondrial function with whole-body metabolism.

How MOTS-c works

Unlike conventional peptide hormones, MOTS-c functions as a mitochondrial signalling peptide, helping cells adapt to metabolic stress.

Η δημοσιευμένη έρευνα έχει εξερευνήσει τη σχέση του με:

Cellular energy metabolism

MOTS-c has been investigated for its ability to regulate cellular energy use during metabolic stress by influencing pathways involved in glucose utilisation and fatty acid metabolism.

Exercise adaptation

Exercise increases endogenous MOTS-c expression, making it one of the most studied mitochondrial-derived peptides in exercise physiology. Researchers have investigated whether MOTS-c contributes to some of the metabolic adaptations normally associated with physical activity.

AMPK signalling

One of the principal mechanisms investigated for MOTS-c involves activation of AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance and metabolic adaptation.

Healthy aging

Because mitochondrial function changes with age, MOTS-c has become an important research target in studies investigating metabolic resilience and healthy aging.

Why MOTS-c is often described as an “exercise peptide”

One of the most interesting observations in the scientific literature is that endogenous MOTS-c levels increase in response to exercise.

Rather than replacing physical activity, researchers are investigating whether MOTS-c activates some of the same cellular pathways involved in exercise-induced metabolic adaptation, particularly those related to mitochondrial function and AMPK signalling. This has led to its description as a potential exercise-mimetic peptide, although this remains an active area of research and should not be interpreted as equivalent to the physiological effects of exercise itself.

Ανθρώπινη και προκλινική έρευνα

Research on MOTS-c is growing rapidly, although the evidence base remains considerably smaller than for established metabolic peptides such as Semaglutide or Tirzepatide.

Published studies have investigated MOTS-c in laboratory models of metabolism, exercise physiology, insulin sensitivity and aging, while human research has primarily focused on endogenous MOTS-c levels and their relationship with metabolic health. Clinical interventional research remains limited.

How MOTS-c differs from related metabolic peptides

Unlike incretin peptides, MOTS-c is investigated primarily for cellular energy regulation and mitochondrial signalling, making it one of the few research peptides that directly targets mitochondrial biology.

Δημοσιευθείσες παρατηρήσεις ασφαλείας

Most published data on MOTS-c come from preclinical studies, with relatively limited human interventional research available. Current investigations have generally reported acceptable tolerability in early studies, but long-term efficacy and safety remain under investigation. Because clinical evidence is still emerging, findings should be interpreted within the context of ongoing research.

Χαρακτηριστικά προϊόντος

Εφαρμογή: εργαστηριακή και αναλυτική έρευνα
Χρήση περιορισμού: όχι για ανθρώπινη κατανάλωση· όχι για ιατρική, κτηνιατρική ή καλλυντική χρήση
Παράγεται σε εγκαταστάσεις που συμμορφώνονται με τις ΟGMP υπό αυστηρά πρωτόκολλα ΠΚ.
Κάθε παρτίδα ελέγχεται προσεκτικά στο εργαστήριο μετά την παραγωγή (μπορείτε να βρείτε το Πιστοποιητικό Ανάλυσης κάτω από τις εικόνες του προϊόντος).
Κατάψυξη-αποξήρανση (λυσόφιλη) για μέγιστη σταθερότητα και παρατεταμένη διάρκεια ζωής.
Σφραγισμένα σε αποστειρωμένες φιάλες, έτοιμα για ανασύσταση.
Purity: ≥98% (HPLC-tested)
Appearance: Lyophilized white/off-white powder
Μοριακός τύπος: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight: 2174.6
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Αποθήκευση: τα αφυδατωμένα σε ξηρή ψύξη, σφραγισμένα φιαλίδια φυλάσσονται καλύτερα συντήρηση στους 2–8°C, η οποία είναι η μέθοδος αποθήκευσης που επιβεβαιώθηκε από τον συνεργάτη παραγωγής μας και είναι κατάλληλη για έως και 24 μήνες. Η ψύξη προτιμάται επειδή ελαχιστοποιεί τους περιττούς κύκλους ψύξης-απόψυξης κατά τον συνήθη χειρισμό. Εάν απαιτείται σημαντικά μακροχρόνια αποθήκευση, τα σφραγισμένα λυοφιλοποιημένα φιαλίδια μπορούν επίσης να διατηρηθούν κατεψυγμένα. Μόλις ανασυσταθεί, αποθηκεύετε πάντα σε 2–8°C και μην καταψύχετε.

Ανα

MOTS-c is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with Βακτηριοστατικό νερό πριν τη χρήση. Για να διατηρηθεί η δομική ακεραιότητα, προσθέστε το επιλεγμένο διαλύτη αργά στο εσωτερικό τοίχωμα του φιαλιδίου αντί απευθείας στη μάζα του πεπτιδίου, και αποφύγετε το έντονο ανακίνημα. Η απαλή περιστροφή είναι γενικά επαρκής μόλις το πεπτίδιο διαλυθεί πλήρως. Η τυπική εργαστηριακή πρακτική περιλαμβάνει επίσης την αναμονή των ψυχόμενων φιαλιδίων να φτάσουν σε θερμοκρασία δωματίου πριν από την ανασύσταση για να ελαχιστοποιηθεί η συμπύκνωση στο εσωτερικό του φιαλιδίου.

Για την επιλογή άλλων διαλυτών, σχεδιασμό συγκεντρώσεων και οδηγίες αποθήκευσης, δείτε το πλήρες Οδηγός Ανασύστασης Πεπτιδίων και Υπολογιστής Απεικόνισης.

Επιλεγμένες ερευνητικές αναφορές

• Lee C, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance, Cell Metabolism, 2015

The landmark paper describing the discovery of MOTS-c and its role in metabolic regulation.

• Zhou H, et al. Mitochondria-derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging, Journal of Translational Medicine, 2023

A comprehensive review summarising current evidence on MOTS-c biology, metabolism, stress adaptation and aging.

• Atakan MM, Bishop DJ. Small Peptides: Could They Have a Big Role in Metabolism and the Response to Exercise?, Journal of Physiology, 2024

A modern review examining mitochondrial-derived peptides, including MOTS-c, with a focus on exercise physiology and metabolic adaptation.

• Bobylev AG, et al. Mitochondrial Peptide MOTS-c: Regulation of Metabolism and Prospects for Clinical and Sports Medicine Applications, Human Physiology, 2025

A review discussing emerging evidence for MOTS-c in metabolism, exercise physiology and healthy aging.

Συχνές Ερωτήσεις

What is MOTS-c?

MOTS-c is a naturally occurring mitochondrial-derived peptide encoded by mitochondrial DNA. It is widely investigated for its role in cellular energy metabolism, exercise adaptation and healthy aging.

Why is MOTS-c associated with exercise research?

Published studies have shown that endogenous MOTS-c levels increase in response to exercise. Researchers are investigating whether it contributes to metabolic adaptations associated with physical activity through pathways such as AMPK signalling.

What makes MOTS-c different from GLP-1 peptides?

Unlike GLP-1 receptor agonists, which primarily investigate incretin signalling, MOTS-c focuses on mitochondrial communication, cellular energy regulation and metabolic adaptation. These represent distinct areas of metabolic research.

What research areas commonly investigate MOTS-c?

Current research includes cellular metabolism, mitochondrial biology, insulin sensitivity, exercise physiology, AMPK signalling, skeletal muscle adaptation and healthy aging.

How does MOTS-c differ from SS-31?

Both are mitochondrial peptides, but they investigate different aspects of mitochondrial biology. MOTS-c is primarily associated with metabolic signalling and exercise adaptation, whereas SS-31 is investigated for mitochondrial membrane integrity and bioenergetics.

Is MOTS-c an exercise replacement?

No. Although MOTS-c has been described as an exercise-mimetic peptide because it activates some exercise-related metabolic pathways, current research does not support the conclusion that it reproduces the full physiological effects of physical exercise.

Αυτό το προϊόν προορίζεται για ανθρώπινη χρήση;

No. MOTS-c supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the scientific literature relating to the MOTS-c molecule rather than the intended use of this product.

Σχετικό ερευνητικό πλαίσιο

MOTS-c is frequently discussed alongside other research peptides investigating mitochondrial function, metabolism and healthy aging, although each targets different aspects of cellular physiology.

ΣΣ-31 (Elamipretide) – investigated for mitochondrial repair and cellular energy production.
Epitalon – studied for telomere biology and healthy aging research.
CJC-1295 με DAC – investigated for sustained GH and IGF-1 signalling.
CJC-1295 Χωρίς DAC – studied for physiological growth hormone release.
GHK-Cu – investigated for tissue regeneration and extracellular matrix remodelling.

NOTE: This is for educational reference only and does not constitute medical advice.

Disclaimer:
Αυτό το προϊόν πωλείται αποκλειστικά για ερευνητικούς σκοπούς. Δεν προορίζεται για τη διάγνωση, θεραπεία, ίαση ή πρόληψη οποιασδήποτε ασθένειας. Ο αγοραστής αναλαμβάνει πλήρως την ευθύνη για τον σωστό χειρισμό και τη χρήση.