NAD+ / 500 mg

Descrizione

NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme found in every living cell. Rather than acting as a signalling peptide or hormone, NAD+ functions as an essential electron carrier in hundreds of metabolic reactions, playing a central role in ATP production, mitochondrial function and cellular repair.

Because NAD+ levels naturally decline with age and metabolic stress, it has become one of the most extensively investigated molecules in research on aging, energy metabolism and mitochondrial biology.

Why NAD+ is widely investigated

Published research has investigated NAD+ in relation to:

• cellular energy production
• mitochondrial function
• healthy aging
• DNA repair
• oxidative stress
• metabolic health
• cognitive function
• muscle physiology
• sirtuin biology

Unlike mitochondrial peptides, NAD+ serves as a fundamental metabolic cofactor required for normal cellular function across virtually every tissue.

How NAD+ works

Cellular energy production

NAD+ plays a central role in converting nutrients into usable cellular energy. It transfers electrons during glycolysis, the citric acid cycle and oxidative phosphorylation, allowing mitochondria to generate ATP efficiently.

Mitochondrial function

Healthy mitochondria depend on adequate NAD+ availability to support normal energy metabolism. Research has investigated how declining NAD+ levels influence mitochondrial performance during aging and metabolic stress.

DNA repair

NAD+ serves as an essential substrate for enzymes involved in DNA repair, including PARPs, which respond to DNA damage by helping maintain genomic stability.

Sirtuin activation

NAD+ is also required by sirtuins, a family of enzymes involved in cellular stress responses, metabolism and healthy aging. This relationship has made NAD+ a central focus of longevity research.

Why NAD+ is different from mitochondrial peptides

Although frequently discussed together, NAD+, SS-31 and MOTS-c investigate different aspects of mitochondrial biology.

NAD+ supplies an essential coenzyme required for cellular energy metabolism.
SS-31 investigates mitochondrial membrane integrity and ATP production.
MOTS-c studies metabolic signalling and adaptive cellular responses.

Together, these represent complementary areas of cellular energy research rather than competing mechanisms.

Ricerca umana e preclinica

NAD+ has been investigated extensively in both laboratory and clinical settings.

Current research explores its role in aging, metabolic disorders, neurodegeneration, cardiovascular physiology and mitochondrial disease. Much of this work also focuses on strategies to increase intracellular NAD+ through precursors such as NMN and nicotinamide riboside, reflecting the importance of NAD+ homeostasis in human physiology.

Although the biological importance of NAD+ is well established, many therapeutic applications remain under active investigation.

Osservazioni di sicurezza pubblicate

As a naturally occurring cellular coenzyme, NAD+ has been the subject of extensive biological research.

Clinical investigations have generally reported favourable tolerability across a range of study designs, although research continues to evaluate optimal delivery methods, pharmacokinetics and potential applications in age-related disease.

Caratteristiche del prodotto

Applicazione: ricerca di laboratorio e analitica
Uso limitato: non per il consumo umano; non per uso medico, veterinario o cosmetico
Prodotto in stabilimenti conformi alle GMP secondo rigidi protocolli di controllo qualità.
Ogni lotto viene accuratamente testato in laboratorio dopo la produzione (puoi trovare il Certificato di Analisi sotto le immagini del prodotto).
Liofilizzato (liofilizzato) per la massima stabilità e una lunga durata di conservazione.
Sigillato in fiale sterili, pronto per la ricostituzione.
Purity: ≥ 99.47% , HPLC tested
Aspetto: polvere liofilizzata bianca
Molecular formula: C₂₁H₂₉N₇O₁₄P₂²⁺
Molecular weight: 665.4

Archiviazioneflaconcini liofilizzati non aperti sono meglio conservati refrigerato a 2–8°C, che è il metodo di conservazione confermato dal nostro partner di produzione e adatto fino a 24 mesi. Si preferisce la refrigerazione perché minimizza inutili cicli di congelamento-scongelamento durante la manipolazione di routine. Se è necessaria una conservazione a termine sostanzialmente più lungo, i flaconcini liofilizzati non aperti possono anche essere conservati congelati. Una volta ricostituita, conservare sempre a 2-8°C e non congelare.

Ricostituzione e manipolazione

NAD+ is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with acqua batteriostatica prima dell'uso. Per aiutare a preservare l'integrità strutturale, aggiungere il solvente scelto lentamente contro la parete interna del flaconcino piuttosto che direttamente sulla polvere del peptide, ed evitare agitazioni vigorose. Il delicato movimento rotatorio è generalmente sufficiente una volta che il peptide si è completamente sciolto. La pratica standard di laboratorio include anche il far raggiungere ai flaconcini refrigerati la temperatura ambiente prima della ricostituzione per minimizzare la condensa all'interno del flaconcino.

Per altre indicazioni sulla scelta del solvente, sulla pianificazione della concentrazione e sullo stoccaggio, consultare il pieno Guida alla Ricostituzione dei Peptidi e Calcolatore di Ricostituzione.

Riferimenti di ricerca selezionati

• Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ Metabolism and Its Roles in Cellular Processes During Ageing, Nature Reviews Molecular Cell Biology, 2021.

A comprehensive review of NAD+ biology, aging, metabolism and mitochondrial function.

• Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and Nicotinamide Riboside, Cell Metabolism, 2018.

A landmark review summarising NAD+ metabolism and strategies for restoring intracellular NAD+.

• Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD+ Boosting Molecules, Nature Reviews Drug Discovery, 2018.

A detailed overview of NAD+ biology and current therapeutic research.

Domande Frequenti

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme essential for cellular energy production, mitochondrial function and DNA repair.

Is NAD+ a peptide?

No. NAD+ is not a peptide. It is a naturally occurring coenzyme found in every living cell and plays a central role in energy metabolism.

Why is NAD+ important for mitochondria?

NAD+ acts as an electron carrier during cellular respiration, allowing mitochondria to produce ATP efficiently and maintain normal energy metabolism.

How is NAD+ different from MOTS-c?

Although both investigate mitochondrial biology, NAD+ functions as an essential metabolic coenzyme, whereas MOTS-c acts as a mitochondrial signalling peptide that regulates cellular metabolism.

How is NAD+ different from SS-31?

SS-31 investigates the structural integrity of mitochondria by targeting the inner mitochondrial membrane, while NAD+ serves as a fundamental coenzyme required for cellular energy production.

Questo prodotto è destinato all'uso umano?

No. NAD+ supplied by LIFE Peptide is intended strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease.

Contesto di ricerca correlato

NAD+ is frequently discussed alongside other research compounds investigating cellular energy, mitochondrial biology and healthy aging, although each targets distinct biological mechanisms.

SS-31 (Elamipretide) – investigated for mitochondrial repair and cellular energy production.
MOTS-c – studied for metabolic signalling and exercise adaptation.
Epitalon – investigated for telomere biology and healthy aging research.
GHK-Cu – studied for tissue regeneration and cellular repair.
CJC-1295 con DAC – investigated for sustained GH and IGF-1 signalling.

NOTA: Questo è solo a scopo didattico e non costituisce parere medico.

Disclaimer
Questo prodotto è venduto esclusivamente a scopo di ricerca. Non è destinato a diagnosticare, trattare, curare o prevenire alcuna malattia. L'acquirente si assume la piena responsabilità per la corretta manipolazione e utilizzo.