Kisspeptin-10 / 5 mg

Description

Kisspeptin-10 is the shortest biologically active fragment of the endogenous kisspeptin peptide family and one of the most important signalling molecules in reproductive endocrinology.

Rather than acting directly on the testes or ovaries, Kisspeptin-10 stimulates the KISS1 receptor (GPR54) on hypothalamic neurons, initiating the release of gonadotropin-releasing hormone (GnRH). This activates the entire hypothalamic-pituitary-gonadal (HPG) axis, regulating luteinising hormone (LH), follicle-stimulating hormone (FSH) and downstream reproductive hormone production.

Because of this central role, Kisspeptin has become one of the most extensively investigated peptides in fertility research, reproductive endocrinology and neuroendocrine physiology.

Why Kisspeptin-10 matters in fertility research

Unlike compounds that directly replace hormones, Kisspeptin-10 works by activating the body’s natural reproductive hormone signalling pathway.

Published research has investigated Kisspeptin-10 in relation to:

• fertility research
• reproductive hormone regulation
• GnRH signalling
• LH and FSH secretion
• ovulation physiology
• male reproductive endocrinology
• female reproductive endocrinology
• puberty regulation
• hypothalamic-pituitary-gonadal (HPG) axis function

Because Kisspeptin sits at the top of the reproductive hormone cascade, it has become a cornerstone peptide in modern reproductive research.

How Kisspeptin-10 works

Unlike peptides that act directly on endocrine glands, Kisspeptin-10 functions through the KISS1 receptor, activating hypothalamic GnRH neurons.

Publikovaný výzkum zkoumal jeho vztah s:

GnRH secretion

Kisspeptin is recognised as the primary physiological trigger for GnRH release and subsequent reproductive hormone signalling.

LH and FSH regulation

Activation of GnRH neurons leads to pulsatile secretion of luteinising hormone and follicle-stimulating hormone from the pituitary.

Puberty and reproductive maturation

Research has demonstrated that Kisspeptin signalling plays a central role in the onset of puberty and maintenance of reproductive function.

Neuroendocrine integration

Studies have investigated how Kisspeptin integrates nutritional status, metabolic signals and reproductive physiology within the hypothalamus.

Why Kisspeptin-10 is widely investigated in fertility research

Kisspeptin occupies a unique position because it regulates the reproductive hormone axis at its highest physiological level.

Published studies have explored:

• fertility
• assisted reproduction (IVF)
• reproductive hormone secretion
• ovulation induction
• fertility physiology
• male reproductive hormones
• female reproductive hormones
• hypothalamic amenorrhoea
• delayed puberty
• reproductive neuroendocrinology

More recently, researchers have also investigated the relationship between Kisspeptin signalling, sexual behaviour and emotional processing, expanding its role beyond classical reproductive endocrinology.

Lidský a preklinický výzkum

Kisspeptin has one of the strongest human evidence bases among neuroendocrine peptides.

Clinical investigations have demonstrated predictable stimulation of reproductive hormones through physiological activation of the HPG axis, while more recent studies have examined its effects on neural processing related to attraction, emotional responses and sexual behaviour. Research continues to explore potential applications in reproductive disorders, infertility and neuroendocrine regulation.

How Kisspeptin-10 differs from other reproductive peptides

Kisspeptin-10

• Fertility and reproductive hormone regulation
• GnRH regulation
• HPG axis research

PT-141

• Melanocortin receptor agonist
• Sexual arousal research
• Central nervous system signalling

Oxytocin

• Social bonding
• Pair bonding
• Maternal behaviour
• Neuroendocrine signalling

Although these peptides are often discussed together, they regulate different aspects of reproductive biology. Kisspeptin primarily controls reproductive hormone signalling, while PT-141 influences sexual motivation, Oxytocin regulates social behaviour, and Melanotan II primarily affects pigmentation.

Publikované bezpečnostní poznatky

Published human studies have generally reported Kisspeptin administration to be well tolerated within controlled research settings. Because it stimulates the physiological reproductive hormone cascade rather than directly replacing hormones, current investigations have focused on transient endocrine responses and neuroendocrine regulation. Ongoing research continues to evaluate its broader therapeutic potential.

Vlastnosti produktu

Aplikace: laboratorní a analytický výzkum
Použití omezené: není určeno k lidské spotřebě; pro lékařské, veterinární ani kosmetické použití
Vyrobeno v zařízeních splňujících správnou výrobní praxi (GMP) za přísných protokolů kontroly kvality.
Každá šarže je po výrobě pečlivě laboratorně testována (Certifikát o analýze najdete pod obrázky produktů).
Lyofilizováno (sušeno mrazem) pro maximální stabilitu a prodlouženou trvanlivost.
Uzavřeno ve sterilních lahvičkách, připraveno k rekonstituci.
Purity: ≥99% (HPLC-tested)
Appearance: Lyophilized white/off-white powder
Molekulární vzorec: C₆₃H₈₃N₁₇O₁₄
Molecular weight: 1302.44
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

ÚložištěNeotevřené lyofilizované lahvičky jsou nejlépe skladovány chlazené při 2–8 °C, což je metoda skladování potvrzená naším výrobním partnerem a vhodná až po dobu 24 měsíců. Preferuje se chlazení, protože minimalizuje zbytečné cykly zmrazování a rozmrazování během běžné manipulace. Pokud je vyžadováno podstatně delší skladování, lze zmrazené uchovávat i neotevřené lyofilizované lahvičky. Po rekonstituci vždy skladujte při 2–8 °C a nezmrazujte.

Rekonstituce a manipulace

Kisspeptin is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting. Must be reconstituted with bakteriostatická voda před použitím. Pro zachování strukturální integrity přidejte zvolené rozpouštědlo pomalu po vnitřní stěně lahvičky namísto přímo na peptidový prášek a vyhněte se prudkému protřepávání. Jemné kroužení je obecně dostačující, jakmile se peptid zcela rozpustí. Standardní laboratorní postupy zahrnují také ponechání chlazených lahviček dosáhnout pokojové teploty před rekonstitucí, aby se minimalizovala kondenzace uvnitř lahvičky.

Pro další pokyny k výběru rozpouštědla, plánování koncentrací a skladování viz úplné Průvodce rekonstitucí peptidů a Kalkulačka rekonstituce.

Klíčové publikované studie

• Dhillo WS, Comninos AN, et al. Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin. Journal of Clinical Endocrinology & Metabolism, 2025.

A comprehensive review covering Kisspeptin’s role in reproductive endocrinology, emotional processing and sexual behaviour.

• Stoynev N, Kumanov P. Kisspeptin System – Physiology and Clinical Perspectives. Annales d’Endocrinologie, 2025.

A modern review of Kisspeptin physiology, reproductive endocrinology and emerging clinical applications.

• Chakraborty AP, Banerjee A. Kisspeptin Isoforms: Versatile Players in Reproduction and Beyond. Journal of Molecular Endocrinology, 2025.

A detailed review explaining Kisspeptin isoforms, receptor biology and regulation of the HPG axis.

• Comninos AN, et al. Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans. Journal of Clinical Endocrinology & Metabolism, 2025.

Human research examining endocrine responses and behavioural outcomes following Kisspeptin administration.

Často kladené otázky

What is Kisspeptin-10?

Kisspeptin-10 is the shortest biologically active fragment of the kisspeptin peptide family. It activates the KISS1 receptor (GPR54) and serves as the body’s natural trigger for GnRH release, making it one of the most important peptides in reproductive hormone research.

Why is Kisspeptin-10 important in fertility research?

Kisspeptin regulates the reproductive hormone cascade by stimulating GnRH secretion. This subsequently controls LH and FSH release, making Kisspeptin a central peptide in studies of fertility, ovulation and reproductive endocrinology.

How does Kisspeptin-10 differ from PT-141?

Although both peptides are investigated within reproductive research, they have different purposes. Kisspeptin-10 regulates reproductive hormone signalling through the HPG axis, whereas PT-141 primarily acts on melanocortin receptors involved in sexual desire and arousal.

Can Kisspeptin-10 influence testosterone or estrogen?

Kisspeptin does not directly stimulate testosterone or oestrogen production. Instead, it activates GnRH release, which subsequently regulates LH and FSH secretion and the downstream production of sex hormones through the body’s natural endocrine pathways.

What research areas commonly investigate Kisspeptin-10?

Published research includes fertility, reproductive hormone regulation, GnRH signalling, LH and FSH secretion, ovulation, puberty, reproductive endocrinology, hypothalamic amenorrhoea and neuroendocrine physiology.

Can Kisspeptin-10 influence brain function as well as reproductive hormones?

Yes. Recent studies have investigated the relationship between Kisspeptin signalling and emotional processing, attraction, mood and reproductive behaviour, expanding its research beyond classical reproductive endocrinology.

Je tento produkt určen k lidskému použití?

No. Kisspeptin-10 supplied by LIFE Peptide is provided strictly for laboratory and analytical research. It is not intended for human consumption, diagnosis, treatment or prevention of disease. Any discussion of published studies summarises the current scientific literature relating to the Kisspeptin-10 molecule rather than the intended use of this product.

Související výzkumný kontext

Kisspeptin-10 belongs to the broader neuroendocrine and peptide signaling research category, focusing on hypothalamic regulation and reproductive endocrine communication pathways.
Researchers exploring related neuroendocrine signaling models may also examine:

• PT-141 — melanocortin-mediated neuroendocrine signaling research
• Sekre sagoga růstového hormonu — hypothalamic and pituitary pathway interaction
• Cognitive & neuroresearch peptides — CNS peptide signaling models

NOTE: This is for educational reference only and does not constitute medical advice.

Disclaimer:
Tento produkt je prodáván pouze pro výzkumné účely. Není určen k diagnostice, léčbě, vyléčení nebo prevenci jakýchkoli onemocnění. Kupující přebírá plnou odpovědnost za řádnou manipulaci a použití.